Pathophysiology of Testis
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 438
Special Issue Editors
Interests: spermatogenesis; germ cells; sertoli cells; sperm; inflammation; immune privilege; nanoplatforms; cell therapy; molecular biology
Interests: testis; male infertility; inflammation; aging; oxidative stress; melatonin; prostaglandins
Interests: sertoli cells; germ cells; testis; proliferation; cell metabolism; metabolomics; cell biology; molecular biology
Special Issue Information
Dear Colleagues,
The male gonad has both endocrine and reproductive functions. Testicular development and spermatogenesis are under multiple levels of regulation. A complex network of intercellular communication exists between germ cells, Sertoli cells, peritubular myoid cells, Leydig cells, endothelial cells, and macrophages, which is regulated either by direct cell-to-cell contacts, cell-secreted factors—acting in a paracrine, autocrine or intracrine manner—the intercellular transfer of extracellular vesicles, and the phase-specific expression of microRNAs.
Disturbance at any level might alter steroidogenesis, cell energetic metabolism, cell proliferation, and/or sperm production and lead to infertility or subfertility.
This Special Issue aims to explore the molecular and cellular events that govern normal testicular development, testicular cell proliferation, the maintenance of energy balance and ageing, as well as testicular pathology of an immunological, inflammatory, genetic/epigenetic, or unknown etiology. Multi-omic approaches, including single-cell RNA sequencing analysis, metabolomics, and proteomics, contribute to a better understanding of testicular pathophysiology.
Male infertility due to testicular failure has traditionally been regarded as an unchangeable condition due to the lack of effective pharmacological therapies. We encourage research into approaches for the diagnosis and treatment of testicular pathology, which will improve the ability to employ evidence-based medicine in the treatment of 'idiopathic' male infertility.
Dr. María Susana Theas
Dr. Mónica Beatriz Frungieri
Dr. María Noel Galardo
Guest Editors
Manuscript Submission Information
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Keywords
- testis
- infertility
- aging
- inflammation
- spermatogenesis
- steroidogenesis
- energy balance
