Molecular Sciences in Cardiology and Vascular Disorders

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Biochemistry and Molecular Biology".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 1244

Special Issue Editor

West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China
Interests: atherosclerosis; microcirculatory dysfunction

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to the Special Issue “Molecular Sciences in Cardiology and Vascular Disorders”. This issue sets forth in an enlightening exploration into the sophisticated realm of molecular biomedicine with an exclusive focus on cardiology and vascular disorders. By harnessing the principles of biology, chemistry, biomechanics, and medical science, this interdisciplinary field has considerably enriched our understanding of the complex operations and mechanisms underpinning the cardiovascular system.

Considering the global prevalence of cardiac and vascular diseases, the necessity for progression in this particular field is heightened. With the implementation of cutting-edge tools and methodologies hailing from molecular genetics, biochemistry, biophysics, and computational biology, cardiovascular research is experiencing a paradigm shift, revealing unprecedented insights, pioneering experimental models, and offering promising therapeutic approaches for these disorders.

The advances made in this vibrant field hold great promise, not only in expanding our understanding of cardiovascular pathophysiology, but crucially in driving forward the development methodology for combating ever-increasing cardiac and vascular disorders.

This Special Issue aims to serve as an exceptional platform for showcasing innovative research in the sphere of cardiac and vascular molecular sciences. We endeavor to stimulate thought-provoking discussions that expand our aggregated knowledge, incite innovative research avenues, and stimulate the creation of cutting-edge diagnostic mechanisms for cardiovascular diseases.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • molecular and genetic aspects of cardiovascular diseases;
  • biochemistry of cardiac and vascular systems;
  • biophysics in cardiovascular diseases;
  • computational modeling of cardiovascular functions;
  • stem cell and regeneration;
  • signaling in the cardiac and vascular systems;
  • pathophysiology of cardiovascular diseases.

We look forward to receiving your contributions.

Dr. Ye Zeng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiology
  • vascular disorders
  • atherosclerosis
  • microcirculation
  • biomechanics
  • biochemistry and molecular biology
  • cell biology
  • signaling pathway

Published Papers (1 paper)

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Research

15 pages, 20759 KiB  
Article
Deletion of Interleukin-1β Converting Enzyme Alters Mouse Cardiac Structure and Function
by Gohar Azhar, Koichiro Nagano, Pankaj Patyal, Xiaomin Zhang, Ambika Verma and Jeanne Y. Wei
Biology 2024, 13(3), 172; https://doi.org/10.3390/biology13030172 - 07 Mar 2024
Viewed by 999
Abstract
Interleukin-1β converting enzyme (ICE, caspase-1) is a thiol protease that cleaves the pro-inflammatory cytokine precursors of IL-1β and IL-18 into active forms. Given the association between caspase-1 and cardiovascular pathology, we analyzed the hearts of ICE knockout (ICE KO) mice to test the [...] Read more.
Interleukin-1β converting enzyme (ICE, caspase-1) is a thiol protease that cleaves the pro-inflammatory cytokine precursors of IL-1β and IL-18 into active forms. Given the association between caspase-1 and cardiovascular pathology, we analyzed the hearts of ICE knockout (ICE KO) mice to test the hypothesis that caspase-1 plays a significant role in cardiac morphology and function. We characterized the histological and functional changes in the hearts of ICE KO mice compared to the Wild type. The cardiomyocytes from the neonatal ICE KO mice showed an impaired response to oxidative stress. Subsequently, the hearts from the ICE KO mice were hypertrophied, with a significant increase in the left ventricular and septal wall thickness and a greater LV mass/body weight ratio. The ICE KO mice hearts exhibited irregular myofibril arrangements and disruption of the cristae in the mitochondrial structure. Proapoptotic proteins that were significantly increased in the hearts of ICE KO versus the Wild type included pErk, pJNK, p53, Fas, Bax, and caspase 3. Further, the antiapoptotic proteins Bag-1 and Bcl-2 are activated in ICE KO hearts. Functionally, there was an increase in the left ventricular epicardial diameter and volume in ICE KO. In conclusion, our findings support the important role of caspase-1 in maintaining cardiac health; specifically, a significant decrease in caspase-1 is detrimental to the cardiovascular system. Full article
(This article belongs to the Special Issue Molecular Sciences in Cardiology and Vascular Disorders)
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