The Cellular and Molecular Bases for Inflammatory Bowel Diseases (IBDs)
A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 294
Special Issue Editor
Special Issue Information
Dear Colleagues,
Inflammatory bowel diseases (IBDs) comprise Ulcerative Colitis and Crohn’s disease, both are relapsing inflammatory diseases, mainly affecting the gastrointestinal tract with potential extraintestinal manifestations. It is accepted that, during an IBD, the intestinal barrier function is compromised, facilitating the infiltration of bacteria and their products into the lamina propria and even the systemic circulation. In response to this bacterial stimuli, immune cells in the lamina propria are activated to release pro-inflammatory cytokines, which enhance the further infiltration of immune cells and result in chronic intestinal inflammation. The incidence of IBDs is continually growing among children and adults all over the world. Advances in understanding IBD pathophysiology are needed to develop innovative diagnostic and therapeutic strategies for treating IBDs.
Since IBDs are multifactorial disorders, disease mechanisms include not only innate and adaptive immunity but also interactions between genetic factors, environment, and microbiota. Accordingly, this Special Issue aims to gather new insights into the cellular or molecular aspects related to the pathophysiology of IBDs. This Special Issue will include original research articles, high-quality meta-analyses, and state-of-the-art reviews discussing recent findings regarding molecular and cellular insights into the onset and maintenance of IBDs. Studies on clinical and experimental treatment strategies are also welcome.
Dr. Elisa Wirthgen
Guest Editor
Manuscript Submission Information
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Keywords
- intestinal inflammation
- mucosa
- lamina propria
- colitis ulcerosa
- Crohn’s disease
- endotoxin tolerance
- treatment strategies
- inflammatory bowel diseases
- immune cells
