Systems Immunology Approaches in Infectious Diseases

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Immunology".

Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 4037

Special Issue Editors


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Guest Editor
Department of Pediatrics, University of Tennessee Health Science Center, Molecular Science Building, Room 820, 858 Madison Ave, Memphis, TN 38163, USA
Interests: quantitative virology; quantitative immunology; coinfection biology; infectious diseases; mathematical modeling

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Guest Editor
1. The Roger Williams Institute of Hepatology, Foundation for Liver Research, London SE5 9NT, UK
2. Faculty of Life Sciences and Medicine, King's College London, London WC2R 2LS, UK
Interests: immunology; liver disease; biostatistics; gut-body axis
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Special Issue Information

Dear Colleagues,

With the advent of advanced molecular technologies, a massive amount of immunological data is now available in the field of infectious diseases. In addition, the scale and complexity of analysis have grown along with the large dimension of these datasets. As a result, systematic investigation using quantitative tools such as bioinformatics, mathematical, and statistical modeling are playing a critical role in providing accurate approximations of the complicated patterns in immunological data. Thus, incorporating and applying mathematics, computer science, engineering, and biology, the Systems Biology approach allows a simplified representation of the complex host–pathogen interactions during infections and enhances our ability to investigate and combat diseases, all with increased accuracy, timeliness, and efficiency.

This research topic will be designed to feature the latest novel findings about molecular and cellular mechanisms of host antiviral defense from high-throughput experimental methodologies to computational and theoretical approaches. All papers will be comprised of multidisciplinary approaches to handling the existing challenges faced in this fast-growing field. The vision of this Special Issue is to bring clinicians; engineers; basic scientists such as biologists, immunologists, physicists, and mathematicians; and big data analytics together to provide readers with the current state of the art of systems biology approaches in understanding immunity against pathogens, and aiding the development of antiviral therapies.

Dr. Lubna Pinky
Dr. Antonio Riva
Guest Editors

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Keywords

  • innate and adaptive immunity
  • multi-pathogen infections or coinfections
  • antimicrobial resistance
  • emerging infectious diseases
  • genomic, proteomic, and metabolic analysis
  • imaging
  • machine learning techniques
  • computational modeling
  • nonlinear analysis
  • statistical analysis

Published Papers (1 paper)

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Research

14 pages, 995 KiB  
Article
Determination of the Concentration of IgG against the Spike Receptor-Binding Domain That Predicts the Viral Neutralizing Activity of Convalescent Plasma and Serum against SARS-CoV-2
by Llipsy Santiago, Iratxe Uranga-Murillo, Maykel Arias, Andrés Manuel González-Ramírez, Javier Macías-León, Eduardo Moreo, Sergio Redrado, Ana García-García, Víctor Taleb, Erandi Lira-Navarrete, Ramón Hurtado-Guerrero, Nacho Aguilo, Maria del Mar Encabo-Berzosa, Sandra Hidalgo, Eva M. Galvez, Ariel Ramirez-Labrada, Diego de Miguel, Rafael Benito, Patricia Miranda, Antonio Fernández, José María Domingo, Laura Serrano, Cristina Yuste, Sergio Villanueva-Saz, José Ramón Paño-Pardo and Julián Pardoadd Show full author list remove Hide full author list
Biology 2021, 10(3), 208; https://doi.org/10.3390/biology10030208 - 10 Mar 2021
Cited by 16 | Viewed by 3371
Abstract
Several hundred millions of people have been diagnosed of coronavirus disease 2019 (COVID-19), causing millions of deaths and a high socioeconomic burden. SARS-CoV-2, the causative agent of COVID-19, induces both specific T- and B-cell responses, being antibodies against the virus detected a few [...] Read more.
Several hundred millions of people have been diagnosed of coronavirus disease 2019 (COVID-19), causing millions of deaths and a high socioeconomic burden. SARS-CoV-2, the causative agent of COVID-19, induces both specific T- and B-cell responses, being antibodies against the virus detected a few days after infection. Passive immunization with hyperimmune plasma from convalescent patients has been proposed as a potentially useful treatment for COVID-19. Using an in-house quantitative ELISA test, we found that plasma from 177 convalescent donors contained IgG antibodies specific to the spike receptor-binding domain (RBD) of SARS-CoV-2, although at very different concentrations which correlated with previous disease severity and gender. Anti-RBD IgG plasma concentrations significantly correlated with the plasma viral neutralizing activity (VN) against SARS-CoV-2 in vitro. Similar results were found using an independent cohort of serum from 168 convalescent health workers. These results validate an in-house RBD IgG ELISA test in a large cohort of COVID-19 convalescent patients and indicate that plasma from all convalescent donors does not contain a high enough amount of anti-SARS-CoV-2-RBD neutralizing IgG to prevent SARS-CoV-2 infection in vitro. The use of quantitative anti-RBD IgG detection systems might help to predict the efficacy of the passive immunization using plasma from patients recovered from SARS-CoV-2. Full article
(This article belongs to the Special Issue Systems Immunology Approaches in Infectious Diseases)
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