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Special Issue "Essential Trace Elements in the Human Metabolism"

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Dr. José Armando L. da Silva
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Centro de Química Estrutural, Instituto Superior Técnico (IST), Universidade de Lisboa, Av. Rovisco Pais 1, 1049-001 Lisboa, Portugal
Interests: bioinorganic chemistry; prebiotic chemistry

Special Issue Information

Dear Colleagues,

This Special Issue will serve to highlight how trace elements, despite their low levels in the human body, are absolutely essential for metabolism. The proposed subject is transversal and of great interest in several areas, e.g., medicine and other areas of health, quality of life, and food production. Therefore, developments on the topic of "Essential Trace Elements in the Human Metabolism” have consequences in different fields.

This Special Issue aims to gather contributions from relevant researchers (including their co-authors) across the world and from different backgrounds, hence promoting richer and more diverse information to be distributed to readers. Papers based on experimental work or reviews are welcome to be submitted to this Special Issue.

Dr. José Armando L. da Silva
Guest Editor

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Keywords

chromium
cobalt
copper
iodine
manganese
molybdenum
selenium
zinc

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Research

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Open AccessArticle

Trace Element Imbalances in Acquired Hepatocerebral Degeneration and Changes after Liver Transplant

Henrique Nascimento

Maria João Malaquias

Catarina Mendes Pinto

Helena Pessegueiro Miranda

Agostinho Almeida

and

Marina Magalhães

Biology 2023, 12(6), 804; https://doi.org/10.3390/biology12060804 - 31 May 2023

Viewed by 306

Abstract

Brain manganese (Mn) accumulation is a key feature in patients with acquired hepatocerebral degeneration (AHD). The role of trace elements other than Mn in AHD needs to be clarified. In this study, using inductively coupled plasma mass spectrometry, we aimed to evaluate blood levels of trace elements in patients with AHD before and after liver transplantation (LT). Trace element levels in the AHD group were also compared with those of healthy controls (blood donors, n = 51). Fifty-one AHD patients were included in the study (mean age: 59.2 ± 10.6 years; men: 72.5%). AHD patients had higher levels of Mn, Li, B, Ni, As, Sr, Mo, Cd, Sb, Tl and Pb and a higher Cu/Se ratio, and lower levels of Se and Rb. Six patients (two women; mean age 55 ± 8.7 years) underwent LT, and there was an improvement in neurological symptoms, a significant increase in the Zn, Se and Sr levels, and a decrease in the Cu/Zn and Cu/Se ratios. In summary, several trace element imbalances were identified in AHD patients. Liver transplantation resulted in the improvement of neurological manifestations and the oxidant/inflammatory status. It is possible that observed changes in trace element levels may play a role in the pathophysiology and symptomatology of AHD. Full article

(This article belongs to the Special Issue Essential Trace Elements in the Human Metabolism)

Review

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Open AccessReview

Improving Dietary Zinc Bioavailability Using New Food Fortification Approaches: A Promising Tool to Boost Immunity in the Light of COVID-19

and

Biology 2023, 12(4), 514; https://doi.org/10.3390/biology12040514 - 29 Mar 2023

Viewed by 1268

Abstract

Zinc is a powerful immunomodulatory trace element, and its deficiency in the body is closely associated with changes in immune functions and viral infections, including SARS-CoV-2, the virus responsible for COVID-19. The creation of new forms of zinc delivery to target cells can make it possible to obtain smart chains of food ingredients. Recent evidence supports the idea that the optimal intake of zinc or bioactive compounds in appropriate supplements should be considered as part of a strategy to generate an immune response in the human body. Therefore, controlling the amount of this element in the diet is especially important for populations at risk of zinc deficiency, who are more susceptible to the severe progression of viral infection and disease, such as COVID-19. Convergent approaches such as micro- and nano-encapsulation develop new ways to treat zinc deficiency and make zinc more bioavailable. Full article

(This article belongs to the Special Issue Essential Trace Elements in the Human Metabolism)

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Special Issue "Essential Trace Elements in the Human Metabolism"

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