Advances in Biological Breast Cancer Research

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Cancer Biology".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1767

Special Issue Editors


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Guest Editor
Department of Physiological Sciences, Faculty of Natural Sciences, Stellenbosch University, Stellenbosch 7600, South Africa
Interests: breast cancer; cancer treatment; cancer cells; cell death; animal models

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Co-Guest Editor
Department of Physiology, University of Pretoria, Pretoria 0007, South Africa
Interests: cancer; cell signaling; cytoskeleton; apoptosis; autophagy; radiation biology; drug discovery; reactive oxygen species

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Co-Guest Editor
Department of Physiology, University of Pretoria, Pretoria 0007, South Africa
Interests: cellular regulation of cancer cell migration and adhesion; the role of GPCRs in cancer biology and metastasis; development of breast cancer organoid models; breast cancer diagnostics
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Special Issue Information

Dear Colleagues,

Breast cancer occurs when carcinogens cause breast epithelial cells to grow uncontrollably. It is one of the most prevalent cancers in the world and the most common type of malignant tumor in women. Fortunately, significant advancements have been made in breast cancer research, improving the success rate of treatment. Using the commonality between breast cancer experimental animal models and human breast cancer in terms of tumor molecular characteristics and biological behavior to study the pathogenesis of various breast cancers and the development of new therapeutic drugs has been particularly helpful. In addition, molecular and cell biology research also contributes to increasing our understanding of breast cancer, leading to more effective diagnosis and treatment options.

In this Special Issue, we aim to collect the latest advances in the study of breast cancer biology, covering mechanisms, diagnosis, regulations, treatment and other related aspects.

Prof. Dr. Anna Mart Engelbrecht
Dr. Joji Mercier
Dr. Iman Van Den Bout
Guest Editors

Manuscript Submission Information

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Keywords

  • breast cancer
  • breast tumor
  • breast cancer cells
  • animal models
  • cell death
  • cancer diagnosis
  • cancer treatment
  • biomarkers
  • cancer microenvironment
  • carcinogens
  • estrogen receptor
  • molecular biology
  • cell biology

Published Papers (1 paper)

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Research

14 pages, 2786 KiB  
Article
Influence of Breast Cancer Extracellular Vesicles on Immune Cell Activation: A Pilot Study
by Jessie Santoro, Barbara Carrese, Maria Sara Peluso, Luigi Coppola, Massimiliano D’Aiuto, Gennaro Mossetti, Marco Salvatore and Giovanni Smaldone
Biology 2023, 12(12), 1531; https://doi.org/10.3390/biology12121531 - 15 Dec 2023
Viewed by 1329
Abstract
Breast cancer is the leading cause of cancer-related death in women worldwide. It is well known that breast cancer shows significant alterations in the tumor microenvironment (TME), which is composed of a variety of immune cells, including natural killer (NK) cells, that have [...] Read more.
Breast cancer is the leading cause of cancer-related death in women worldwide. It is well known that breast cancer shows significant alterations in the tumor microenvironment (TME), which is composed of a variety of immune cells, including natural killer (NK) cells, that have a key role in tumor development or anti-tumor responses in breast cancer patients. Luminal B (BT474) and triple-negative breast cancer (HS578T) cell lines were cultured in 2D and 3D model systems. PMBCs from healthy donors were isolated and treated with extracellular vesicles (EVs) from monolayer and spheroids of BT474 and HS578T and analyzed using cytofluorimetric approaches. We observed that EVs can alter the activation and presence of CD335+/CD11b+ NK cells. EVs derived from BT474 and HS578T cells trigger the activation and, simultaneously, a reduction in the percentage of CD335+/CD11b+ NK cells. In addition, EVs derived from BT474 also significantly reduce CD39+ T-regulatory (T-reg) cells. Our preliminary data suggest that using EVs to treat tumors could potentially alter components of the immune system, which causes hyperactivation of specific cell types and can lead to aggressive growth. These data will guide the designing of new personalized diagnostic approaches based on in-depth study of the TME. Full article
(This article belongs to the Special Issue Advances in Biological Breast Cancer Research)
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