Copper Biology in Health and Disease

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Physiology".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1659

Special Issue Editor


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Guest Editor
Department of Biochemistry, University of Missouri, Columbia, MO 65201, USA
Interests: biochemistry; biology of cancer; drug design and development; molecular biology

Special Issue Information

Dear Colleagues,

We would like to invite researchers and scholars to contribute their expertise to our Special Issue on “Copper Biology in Health and Disease”. This Special Issue aims to explore the multifaceted roles of copper in biological systems and its implications for human health and disease. Submissions are encouraged to delve into various aspects, including the molecular mechanisms of copper homeostasis, its role in cellular processes, and the impact of copper dysregulation on health outcomes.

Researchers are invited to submit original research articles, reviews, and perspectives that advance our understanding of copper biology. Topics of interest include, but are not limited to, copper transporters, copper-dependent enzymes, copper-related diseases, therapeutic applications of copper, and the interplay between copper and other trace elements.

By contributing to this Special Issue, researchers have the opportunity to foster collaboration and share insights that contribute to the broader understanding of copper’s significance in health and disease. Accepted manuscripts will be part of a dedicated collection that showcases the latest advancements in copper biology, providing a valuable resource for the scientific community.

We look forward to receiving innovative and high-quality submissions that contribute to the growing body of knowledge in this field. Join us in unraveling the intricacies of copper biology and its impact on human health and disease.

Dr. Vinit Shanbhag
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • copper and tumor growth
  • cancer
  • chemotherapy
  • copper chelation
  • copper homeostasis
  • metal nutrition
  • copper transport
  • clinical cancer research

Published Papers (1 paper)

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Research

21 pages, 4298 KiB  
Article
Hydroxytyrosol Counteracts Triple Negative Breast Cancer Cell Dissemination via Its Copper Complexing Properties
by Nunzio Perta, Laura Torrieri Di Tullio, Elisa Cugini, Paola Fattibene, Maria Cristina Rapanotti, Ilaria Borromeo, Cinzia Forni, Patrizia Malaspina, Tiziana Cacciamani, Daniele Di Marino, Luisa Rossi and Anastasia De Luca
Biology 2023, 12(11), 1437; https://doi.org/10.3390/biology12111437 - 16 Nov 2023
Cited by 1 | Viewed by 1310
Abstract
Polyphenols have gained increasing attention for their therapeutic potential, particularly in conditions like cancer, due to their established antioxidant and anti-inflammatory properties. Recent research highlights their ability to bind to transition metals, such as copper. This is particularly noteworthy given the key role [...] Read more.
Polyphenols have gained increasing attention for their therapeutic potential, particularly in conditions like cancer, due to their established antioxidant and anti-inflammatory properties. Recent research highlights their ability to bind to transition metals, such as copper. This is particularly noteworthy given the key role of copper both in the initiation and progression of cancer. Copper can modulate the activity of kinases required for the epithelial–mesenchymal transition (EMT), a process fundamental to tumor cell dissemination. We have previously demonstrated the copper-binding capacity of oleuropein, a secoiridoid found in Olea europaea. In the present study, we investigated the effect of hydroxytyrosol, the primary oleuropein metabolite, on the metastatic potential of three triple-negative breast cancer cell lines (MDA-MB-231, MDA-MB-468, and SUM159). We found that hydroxytyrosol modulated the intracellular copper levels, influencing both the epithelial and mesenchymal markers, by downregulating copper-dependent AKT phosphorylation, a member of the EMT signaling cascade, through Western blot, RT-qPCR, and immunofluorescence. Indeed, by optical spectra, EPR, and in silico approaches, we found that hydroxytyrosol formed a complex with copper, acting as a chelating agent, thus regulating its homeostasis and affecting the copper-dependent signaling cascades. While our results bring to light the copper-chelating properties of hydroxytyrosol capable of countering tumor progression, they also provide further confirmation of the key role of copper in promoting the aggressiveness of triple-negative breast cancer cells. Full article
(This article belongs to the Special Issue Copper Biology in Health and Disease)
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