New Insights into Astrocytes and Brain Function

A special issue of Biology (ISSN 2079-7737). This special issue belongs to the section "Neuroscience".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 3171

Special Issue Editor


E-Mail Website
Guest Editor
1. Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA
2. Department of Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA
Interests: astrocyte; microglia; neurogenetics; transcriptional regulation; neurodegenerative disease; Alzheimer disease; Parkinson disease; dementia with Lewy body; chronic pain

Special Issue Information

Dear Colleagues,

Astrocytes, star-shaped glial cells located in the central nervous system, play critical roles in brain development and in the maintenance of normal function, regulating the blood–brain barrier, maintaining metabolite and electrolyte homeostasis, providing neurotrophic support to neurons, and modulating synapses. Recent studies have shown that astrocyte dysregulation may underlie various neurological and neurodegenerative disorders, including multiple sclerosis (MS), Alzheimer disease (AD), Parkinson disease (PD), Huntington disease (HD), stroke, epilepsy, and chronic pain. In addition, astrocytes are important in the response and recovery to injuries and issues such as ischemic stroke, traumatic brain injury, and axon regeneration.

This Special Issue invites authors to submit original research articles and reviews that cover all aspects of astrocytes in brain function, with discussions ranging from the evaluation of the basic function of astrocytes in normal development and brain homeostasis to their dysfunction in various diseases. Scholars should focus in particular on novel technologies and discoveries. Short communications on preliminary, but significant, results will also be considered.

Potential topics include but are not limited to:

  • Astrocyte heterogeneity and regulation
  • Astrocytes in brain homeostasis and function
  • Interaction between astrocytes and neurons as well as other glial cell types
  • Astrocytes in neurodegenerative diseases such as MS, AD, PD, HD
  • Astrocytes in developmental and psychiatric disorders such as Rett syndrome, fragile X syndrome, autism, depression, schizophrenia
  • Astrocytes and chronic pain
  • Astrocyte and neural regeneration

We look forward to receiving your contributions to this Special Issue.

Dr. Guoyan Zhao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • astrocyte
  • neurodegenerative disorders
  • neurodevelopmental disorders
  • psychiatric disorders
  • chronic pain
  • neural regeneration

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

25 pages, 1739 KiB  
Review
Microglia and Astrocytes in Amyotrophic Lateral Sclerosis: Disease-Associated States, Pathological Roles, and Therapeutic Potential
by Justin You, Mohieldin M. M. Youssef, Jhune Rizsan Santos, Jooyun Lee and Jeehye Park
Biology 2023, 12(10), 1307; https://doi.org/10.3390/biology12101307 - 03 Oct 2023
Cited by 3 | Viewed by 2697
Abstract
Microglial and astrocytic reactivity is a prominent feature of amyotrophic lateral sclerosis (ALS). Microglia and astrocytes have been increasingly appreciated to play pivotal roles in disease pathogenesis. These cells can adopt distinct states characterized by a specific molecular profile or function depending on [...] Read more.
Microglial and astrocytic reactivity is a prominent feature of amyotrophic lateral sclerosis (ALS). Microglia and astrocytes have been increasingly appreciated to play pivotal roles in disease pathogenesis. These cells can adopt distinct states characterized by a specific molecular profile or function depending on the different contexts of development, health, aging, and disease. Accumulating evidence from ALS rodent and cell models has demonstrated neuroprotective and neurotoxic functions from microglia and astrocytes. In this review, we focused on the recent advancements of knowledge in microglial and astrocytic states and nomenclature, the landmark discoveries demonstrating a clear contribution of microglia and astrocytes to ALS pathogenesis, and novel therapeutic candidates leveraging these cells that are currently undergoing clinical trials. Full article
(This article belongs to the Special Issue New Insights into Astrocytes and Brain Function)
Show Figures

Figure 1

Back to TopTop