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Editorial Board Members’ Collection Series: Pathology of Cancer and Cardiovascular...
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Editorial Board Members’ Collection Series: Pathology of Cancer and Cardiovascular Disease

A special issue of Biology (ISSN 2079-7737).

Deadline for manuscript submissions: 31 October 2024 | Viewed by 1655

Special Issue Editors

Dr. Mridula Chopra

E-Mail Website
Guest Editor
Institute of Biomedical and Biomolecular Science (IBBS), School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK
Interests: mechanistic investigations into pathology of cancer and cardiovascular disease; diet and lifestyle intervention of cancer; cardiovascular disease and diabetes
Dr. Helen L. Fillmore

E-Mail Website
Guest Editor
Paediatric Neuro-Oncology Laboratory, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, UK
Interests: CNS tumours; neurobiology; blood–brain barrier; neurosciences; neurodevelopment; epigenetics; gene regulation; tumour cell invasion; angiogenesis
Special Issues, Collections and Topics in MDPI journals
Dr. Maurizio Forte

E-Mail Website
Guest Editor
Department of Angio-Cardio-Neurology, IRCCS Neuromed, 86077 Pozzilli, Italy
Interests: cardiovascular diseases; autophagy; nutraceuticals; stroke; mitochondrial dysfunction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular disease (CVD) and cancer are leading causes of death globally. In 2020, the World Health Organization reported an estimation of 19.1 and 10 million deaths from CVD and cancer, respectively. In spite of the known preventable risk factors for both conditions, the screening programmes for early detection and state-of-the-art treatments that have recently become available, the incidence continues to rise. The clinical presentation of these chronic conditions can be different. However, there is an overlap of risk factors such as unhealthy diet, smoking, excess consumption of alcohol, inactivity, socioeconomic status, obesity and biological mechanisms, such as activated nuclear factor kappa B, oxidative stress and chronic inflammation. Interestingly, recently, a causal relationship between the gut microbiota, CVD and cancer has also been highlighted, though this is yet to be further researched.

The aim of this Special Issue is to provide a most recent update on the advances in the field of cancer and CVD pathology, focusing on early detection and diagnosis, including a better understanding of the factors involved in microbiome-mediated mechanisms and in biomarkers for early detection.

This Special Issue on cancer and CVD invites but is not limited to the following topics:

  • Diagnostic pathology of cancer and CVD;
  • Novel molecular mechanisms of cancer and CVD development;
  • Diet and lifestyle interventions for Cancer and Cardiovascular disease;
  • Gut Microbiome and Cancer and CVD;
  • New biomarkers for the early detection of cancer and CVD.

This Special Issue on “Editorial Board Members’ Collection Series: “Pathology of Cancer and Cardiovascular Disease”” welcomes original research articles and reviews in this field.

Dr. Mridula Chopra
Dr. Helen L. Fillmore
Dr. Maurizio Forte
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cancer
  • cardiovascular disease
  • biomarkers
  • gut microbiome
  • inflammation
  • health policy
  • diet and lifestyle

Published Papers (1 paper)

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Research

22 pages, 3384 KiB  
Article
Discovery of TBX20 as a Novel Gene Underlying Atrial Fibrillation
by Ning Li, Yan-Jie Li, Xiao-Juan Guo, Shao-Hui Wu, Wei-Feng Jiang, Dao-Liang Zhang, Kun-Wei Wang, Li Li, Yu-Min Sun, Ying-Jia Xu, Yi-Qing Yang and Xing-Biao Qiu
Biology 2023, 12(9), 1186; https://doi.org/10.3390/biology12091186 - 30 Aug 2023
Viewed by 1165
Abstract
Atrial fibrillation (AF), the most prevalent type of sustained cardiac dysrhythmia globally, confers strikingly enhanced risks for cognitive dysfunction, stroke, chronic cardiac failure, and sudden cardiovascular demise. Aggregating studies underscore the crucial roles of inherited determinants in the occurrence and perpetuation of AF. [...] Read more.
Atrial fibrillation (AF), the most prevalent type of sustained cardiac dysrhythmia globally, confers strikingly enhanced risks for cognitive dysfunction, stroke, chronic cardiac failure, and sudden cardiovascular demise. Aggregating studies underscore the crucial roles of inherited determinants in the occurrence and perpetuation of AF. However, due to conspicuous genetic heterogeneity, the inherited defects accounting for AF remain largely indefinite. Here, via whole-genome genotyping with genetic markers and a linkage assay in a family suffering from AF, a new AF-causative locus was located at human chromosome 7p14.2-p14.3, a ~4.89 cM (~4.43-Mb) interval between the markers D7S526 and D7S2250. An exome-wide sequencing assay unveiled that, at the defined locus, the mutation in the TBX20 gene, NM_001077653.2: c.695A>G; p.(His232Arg), was solely co-segregated with AF in the family. Additionally, a Sanger sequencing assay of TBX20 in another family suffering from AF uncovered a novel mutation, NM_001077653.2: c.862G>C; p.(Asp288His). Neither of the two mutations were observed in 600 unrelated control individuals. Functional investigations demonstrated that the two mutations both significantly reduced the transactivation of the target gene KCNH2 (a well-established AF-causing gene) and the ability to bind the promoter of KCNH2, while they had no effect on the nuclear distribution of TBX20. Conclusively, these findings reveal a new AF-causative locus at human chromosome 7p14.2-p14.3 and strongly indicate TBX20 as a novel AF-predisposing gene, shedding light on the mechanism underlying AF and suggesting clinical significance for the allele-specific treatment of AF patients. Full article
(This article belongs to the Special Issue Editorial Board Members’ Collection Series: Pathology of Cancer and Cardiovascular Disease)
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