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Bioengineering
Special Issues
Advances in the Fabrication of Tissue Mimetics
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Advances in the Fabrication of Tissue Mimetics

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: closed (20 August 2021) | Viewed by 10697

Special Issue Editor

Dr. Jonathan Grasman

E-Mail Website
Guest Editor
New Jersey Institute of Technology, Newark, NJ 07102, USA
Interests: tissue engineering; biomaterials; skeletal muscle tissue engineering; biopolymers; regenerative medicine; tissue innervation; neurovascular interactions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Tissue mimetics are a prominent area of biomedical research, used to study tissue growth in vitro or as engineered tissues designed for implantation to treat traumatic injuries. Broadly speaking, “tissue mimetics” are biomaterial- and/or cell-laden constructs designed to imitate biologic functions and/or entire tissues or organs. Recent advances in these areas of research have focused on the development of mature tissues, such as contractile skeletal muscle or mature neurological mimics of the peripheral or central nervous systems, or the generation of platforms to understand disease onset/progression. This versatile approach has shown enormous progress for the generation of tissue models for tissue engineering applications. 

This Special issue on the “Advances in the Fabrication of Tissue Mimetics” will therefore focus on original research papers and comprehensive reviews, dealing with cutting-edge experimental methodologies for fabricating tissue mimetics as well as biomaterial fabrication and design. Topics of interest for this Special Issue include but are not limited to the following:

  • Development of 3D in vitro models of tissues/organs;
  • Tissue mimetic platforms for understanding tissue formation or disease pathology;
  • Using tissue mimetics to study mechanisms of regeneration;
  • Tissue mimetics designed to improve regeneration or rehabilitation;
  • Strategic/rational design of biomaterials for tissue mimetics;
  • Advanced image-based techniques to probe cellular/matrix interactions within mimetic constructs.

Dr. Jonathan Grasman
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Tissue engineering
  • Regenerative medicine
  • Biomaterials
  • Tissue mimetic
  • Biomimetic
  • Tissue model systems
  • Disease modeling
  • Biomimicry

Published Papers (2 papers)

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Research

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12 pages, 2632 KiB  
Article
Preclinical Efficacy of Pro- and Anti-Angiogenic Peptide Hydrogels to Treat Age-Related Macular Degeneration
by Amanda Acevedo-Jake, Siyu Shi, Zain Siddiqui, Sreya Sanyal, Rebecca Schur, Simon Kaja, Alex Yuan and Vivek A. Kumar
Bioengineering 2021, 8(12), 190; https://doi.org/10.3390/bioengineering8120190 - 23 Nov 2021
Cited by 6 | Viewed by 3358
Abstract
Pro-angiogenic and anti-angiogenic peptide hydrogels were evaluated against the standard of care wet age-related macular degeneration (AMD) therapy, Aflibercept (Eylea®). AMD was modeled in rats (laser-induced choroidal neovascularization (CNV) model), where the contralateral eye served as the control. After administration of [...] Read more.
Pro-angiogenic and anti-angiogenic peptide hydrogels were evaluated against the standard of care wet age-related macular degeneration (AMD) therapy, Aflibercept (Eylea®). AMD was modeled in rats (laser-induced choroidal neovascularization (CNV) model), where the contralateral eye served as the control. After administration of therapeutics, vasculature was monitored for 14 days to evaluate leakiness. Rats were treated with either a low or high concentration of anti-angiogenic peptide hydrogel (0.02 wt% 8 rats, 0.2 wt% 6 rats), or a pro-angiogenic peptide hydrogel (1.0 wt% 7 rats). As controls, six rats were treated with commercially available Aflibercept and six with sucrose solution (vehicle control). Post lasering, efficacy was determined over 14 days via fluorescein angiography (FA) and spectral-domain optical coherence tomography (SD-OCT). Before and after treatment, the average areas of vascular leak per lesion were evaluated as well as the overall vessel leakiness. Unexpectedly, treatment with pro-angiogenic peptide hydrogel showed significant, immediate improvement in reducing vascular leak; in the short term, the pro-angiogenic peptide performed better than anti-angiogenic peptide hydrogel and was comparable to Aflibercept. After 14 days, both the pro-angiogenic and anti-angiogenic peptide hydrogels show a trend of improvement, comparable to Aflibercept. Based on our results, both anti-angiogenic and pro-angiogenic peptide hydrogels may prove good therapeutics in the future to treat wet AMD over a longer-term treatment period. Full article
(This article belongs to the Special Issue Advances in the Fabrication of Tissue Mimetics)
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Review

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28 pages, 2487 KiB  
Review
Recent Advances in Natural Materials for Corneal Tissue Engineering
by Julie F. Jameson, Marisa O. Pacheco, Henry H. Nguyen, Edward A. Phelps and Whitney L. Stoppel
Bioengineering 2021, 8(11), 161; https://doi.org/10.3390/bioengineering8110161 - 26 Oct 2021
Cited by 12 | Viewed by 6689
Abstract
Given the incidence of corneal dysfunctions and diseases worldwide and the limited availability of healthy, human donors, investigators are working to generate engineered cellular and acellular therapeutic approaches as alternatives to corneal transplants from human cadavers. These engineered strategies aim to address existing [...] Read more.
Given the incidence of corneal dysfunctions and diseases worldwide and the limited availability of healthy, human donors, investigators are working to generate engineered cellular and acellular therapeutic approaches as alternatives to corneal transplants from human cadavers. These engineered strategies aim to address existing complications with human corneal transplants, including graft rejection, infection, and complications resulting from surgical methodologies. The main goals of these research endeavors are to (1) determine ideal mechanical properties, (2) devise methodologies to improve the efficacy of engineered corneal grafts and cell-based therapies, and (3) optimize transplantation of engineered tissue structures in the eye. Thus, recent innovations have sought to address these challenges through both in vitro and in vivo studies. This review covers recent work aimed at evaluating engineered materials, potential therapeutic cells, and the resulting cell-material interactions that lead to optimal corneal graft properties. Furthermore, we discuss promising strategies in corneal tissue engineering techniques and in vivo studies in animal models. Full article
(This article belongs to the Special Issue Advances in the Fabrication of Tissue Mimetics)
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