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Bioengineering
Special Issues
Vascularized Composite Tissue Engineering (VCE): An Emerging Field in Regenerative...
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Vascularized Composite Tissue Engineering (VCE): An Emerging Field in Regenerative Transplantation

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 2091

Special Issue Editors

Dr. Jérôme Duisit

E-Mail Website
Guest Editor
1. Centre Hospitalier Universitaire (CHU) de Rennes, Rennes, France
2. Reconstructive and Plastic Surgery Department, Hôpitaux IRIS Sud, Brussels, Belgium
Interests: plastic; reconstructive and aesthetic surgery; tissue regenerative; transplant
Prof. Dr. Nicolas Bertheuil

E-Mail Website
Co-Guest Editor
Centre Hospitalier Universitaire de Rennes, Rennes, France
Interests: body-contouring surgery; reconstructive surgery; perforator flaps; abdominal wall reconstruction; microsurgery; adipose-derived stem cells
Prof. Dr. Patrik Lassus

E-Mail Website
Co-Guest Editor
Head of the Department, Helsinki University Central Hospital, Helsinki, Finland
Interests: microsurgery; plastic and reconstructive surgery; reconstructive surgery; microvascular surgery; facial plastic surgery; head and neck surgery; maxillofacial surgery; surgical flaps; free tissue flaps; facial reconstruction

Special Issue Information

Dear Colleagues,

The future of reconstructive transplantation will rely on regenerative medicine to address and overpass current issues and limitations in the field. Since the first successful hand transplant, the refinement of surgical techniques has led to various over types of vascularized composite tissue allotransplantation (VCA), such as face, abdominal wall, or uterus. However, the offer remains limited by the need for lifelong immunosuppression for a non-vital procedure. The transformation of transplantable body parts, through cell therapy or biofabrication with tissue engineering, represent a true hope: we called the related approach “Vascularized Composite tissue Engineering” (VCE). To be successful, VCE will require a strong association with current VCA knowledge, as well as a very transversal multidisciplinary work, such as tissue engineering, stem cell biology, organ perfusion, and tissue banking, as non-exhaustive examples. Presently, VCE is still a translational research niche; thus, we hope that this Special Issue, Vascularized Composite Tissue Engineering (VCE): an Emerging Field in Regenerative Transplantation, will trigger a dramatic and successful expansion of the research field.

Dr. Jérôme Duisit
Prof. Dr. Nicolas Bertheuil
Prof. Dr. Patrik Lassus
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vascularized composite allotransplantation
  • tissue engineering
  • regenerative medicine
  • plastic surgery
  • decellularization
  • recellularization
  • bioprinting
  • composite graft perfusion
  • cell therapy

Published Papers (2 papers)

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Research

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13 pages, 4626 KiB  
Article
Optimized Decellularization of a Porcine Fasciocutaneaous Flap
by Elise Lupon, Aylin Acun, Corentin B. Taveau, Ruben Oganesyan, Hyshem H. Lancia, Alec R. Andrews, Mark A. Randolph, Curtis L. Cetrulo, Jr., Alexandre G. Lellouch and Basak E. Uygun
Bioengineering 2024, 11(4), 321; https://doi.org/10.3390/bioengineering11040321 - 27 Mar 2024
Viewed by 632
Abstract
Reconstructive techniques to repair severe tissue defects include the use of autologous fasciocutaneous flaps, which may be limited due to donor site availability or lead to complications such as donor site morbidity. A number of synthetic or natural dermal substitutes are in use [...] Read more.
Reconstructive techniques to repair severe tissue defects include the use of autologous fasciocutaneous flaps, which may be limited due to donor site availability or lead to complications such as donor site morbidity. A number of synthetic or natural dermal substitutes are in use clinically, but none have the architectural complexity needed to reconstruct deep tissue defects. The perfusion decellularization of fasciocutaneous flaps is an emerging technique that yields a scaffold with the necessary composition and vascular microarchitecture and serves as an alternative to autologous flaps. In this study, we show the perfusion decellularization of porcine fasciocutaneous flaps using sodium dodecyl sulfate (SDS) at three different concentrations, and identify that 0.2% SDS results in a decellularized flap that is efficiently cleared of its cellular material at 86%, has maintained its collagen and glycosaminoglycan content, and preserved its microvasculature architecture. We further demonstrate that the decellularized graft has the porous structure and growth factors that would facilitate repopulation with cells. Finally, we show the biocompatibility of the decellularized flap using human dermal fibroblasts, with cells migrating as deep as 150 µm into the tissue over a 7-day culture period. Overall, our results demonstrate the promise of decellularized porcine flaps as an interesting alternative for reconstructing complex soft tissue defects, circumventing the limitations of autologous skin flaps. Full article
(This article belongs to the Special Issue Vascularized Composite Tissue Engineering (VCE): An Emerging Field in Regenerative Transplantation)
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Review

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20 pages, 1372 KiB  
Review
The Autonomization Principle in Vascularized Flaps: An Alternative Strategy for Composite Tissue Scaffold In Vivo Revascularization
by Yanis Berkane, David M. Kostyra, Theodoros Chrelias, Mark A. Randolph, Alexandre G. Lellouch, Curtis L. Cetrulo, Jr., Korkut Uygun, Basak E. Uygun, Nicolas Bertheuil and Jérôme Duisit
Bioengineering 2023, 10(12), 1440; https://doi.org/10.3390/bioengineering10121440 - 18 Dec 2023
Cited by 1 | Viewed by 974
Abstract
Autonomization is a physiological process allowing a flap to develop neo-vascularization from the reconstructed wound bed. This phenomenon has been used since the early application of flap surgeries but still remains poorly understood. Reconstructive strategies have greatly evolved since, and fasciocutaneous flaps have [...] Read more.
Autonomization is a physiological process allowing a flap to develop neo-vascularization from the reconstructed wound bed. This phenomenon has been used since the early application of flap surgeries but still remains poorly understood. Reconstructive strategies have greatly evolved since, and fasciocutaneous flaps have progressively replaced muscle-based reconstructions, ensuring better functional outcomes with great reliability. However, plastic surgeons still encounter challenges in complex cases where conventional flap reconstruction reaches its limitations. Furthermore, emerging bioengineering applications, such as decellularized scaffolds allowing a complex extracellular matrix to be repopulated with autologous cells, also face the complexity of revascularization. The objective of this article is to gather evidence of autonomization phenomena. A systematic review of flap autonomization is then performed to document the minimum delay allowing this process. Finally, past and potential applications in bio- and tissue-engineering approaches are discussed, highlighting the potential for in vivo revascularization of acellular scaffolds. Full article
(This article belongs to the Special Issue Vascularized Composite Tissue Engineering (VCE): An Emerging Field in Regenerative Transplantation)
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