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Bioengineering
Special Issues
Extracellular Vesicle for Tumor Targeting Delivery System and Tumor Immunotherapy
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Extracellular Vesicle for Tumor Targeting Delivery System and Tumor Immunotherapy

A special issue of Bioengineering (ISSN 2306-5354).

Deadline for manuscript submissions: closed (16 December 2022) | Viewed by 3573

Special Issue Editors

Dr. Ke Tang

E-Mail Website
Guest Editor
Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430074, China
Interests: tumor therapy; tumor immunology; metabolism; extracellular vesicles
Prof. Dr. Honglin Jin

E-Mail Website
Guest Editor
College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China
Interests: nanomedicine; cancer immunotherapy; nanovaccine; tumor microenvironment; immune regulation; intravital imaging

Special Issue Information

Dear Colleagues,

Since Dr. Peter Wolf first proposed "platelet dust" in 1967, extracellular vesicles (EVs) have been gradually known by us. EVs (including plasma membrane derived microparticles and endosomal derived exosomes) play an important role on information exchange between cells through contained protein, lipids and RNA or DNA. In recent years, due to its histocompatibility, natural carrier characteristics and its removability, EV has been widely used in tumor targeted drug delivery and immunotherapy. This special issue mainly collects research papers, reviews or comments on extracellular vesicles in drug delivery and immunotherapy on tumor, as well as related bioengineering and clinical translational study.

Dr. Ke Tang
Prof. Dr. Honglin Jin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • extracellular vesicles
  • exosome
  • tumor targeted therapy
  • tumor drug delivery
  • tumor immunotherapy

Published Papers (2 papers)

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Review

18 pages, 1142 KiB  
Review
Challenges and Opportunities for Extracellular Vesicles in Clinical Oncology Therapy
by Shuya Lu, Qingfa Cui, Huan Zheng, Yuan Ma, Yanchun Kang and Ke Tang
Bioengineering 2023, 10(3), 325; https://doi.org/10.3390/bioengineering10030325 - 03 Mar 2023
Cited by 1 | Viewed by 1503
Abstract
Extracellular vesicles (EVs) are membrane-bound vesicles that can be released by all cell types. They may have different biogenesis, physical features, and cargo. EVs are important biomarkers for the diagnosis and prediction of many diseases due to their essential role in intercellular communication, [...] Read more.
Extracellular vesicles (EVs) are membrane-bound vesicles that can be released by all cell types. They may have different biogenesis, physical features, and cargo. EVs are important biomarkers for the diagnosis and prediction of many diseases due to their essential role in intercellular communication, their highly variable cargoes, and their accumulation in various body fluids. These natural particles have been investigated as potential therapeutic materials for many diseases. In our previous studies, the clinical usage of tumor-cell-derived microparticles (T-MPs) as a novel medication delivery system was examined. This review summarizes the clinical translation of EVs and related clinical trials, aiming to provide suggestions for safer and more effective oncology therapeutic systems, particularly in biotherapeutic and immunotherapeutic systems. Full article
(This article belongs to the Special Issue Extracellular Vesicle for Tumor Targeting Delivery System and Tumor Immunotherapy)
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18 pages, 359 KiB  
Review
Application of Extracellular Vesicles in Gynecologic Cancer Treatment
by Renwen Zhang, Yixing Zou and Jing Luo
Bioengineering 2022, 9(12), 740; https://doi.org/10.3390/bioengineering9120740 - 29 Nov 2022
Cited by 1 | Viewed by 1549
Abstract
Ovarian, cervical, and endometrial cancer are the three most common gynecological malignancies that seriously threaten women’s health. With the development of molecular biology technology, immunotherapy and targeted therapy for gynecologic tumors are being carried out in clinical treatment. Extracellular vesicles are nanosized; they [...] Read more.
Ovarian, cervical, and endometrial cancer are the three most common gynecological malignancies that seriously threaten women’s health. With the development of molecular biology technology, immunotherapy and targeted therapy for gynecologic tumors are being carried out in clinical treatment. Extracellular vesicles are nanosized; they exist in various body fluids and play an essential role in intercellular communication and in the regulation of various biological process. Several studies have shown that extracellular vesicles are important targets in gynecologic cancer treatment as they promote tumor growth, progression, angiogenesis, metastasis, chemoresistance, and immune system escape. This article reviews the progress of research into extracellular vesicles in common gynecologic tumors and discusses the role of extracellular vesicles in gynecologic tumor treatment. Full article
(This article belongs to the Special Issue Extracellular Vesicle for Tumor Targeting Delivery System and Tumor Immunotherapy)
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