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Bioengineering
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Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis
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Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 18133

Special Issue Editor

Dr. Ivana Savić Pavičin

E-Mail Website
Guest Editor
Department of Dental Anthropology, School of Dental Medicine, University of Zagreb, Zagreb, Croatia
Interests: dental anthropology; endodontics; dental stem cells; forensic dentistry; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The main aim of this Special Issue, “Recent advances in dental diseases: diagnosis, treatment and prognosis”, is to present new and innovative trends and methods used in every aspect of dentistry. Oral health is a very important part of general health. Today, we are witnessing the accelerated development of materials and technology, including those applied in the treatment and general improvement of oral health. Constant progress is necessary to meet the growing demands of the profession and take advantage of the latest knowledge in the field of materials and technology applicable in the dental profession. The regenerative methods and biomaterials are finding increasing use in dental clinical practice. All new knowledge in this field will be a significant and valuable contribution to this Special Issue.

We will be pleased to publish original scientific papers, review papers and case reports that are related to new and innovative approaches in diagnostics, therapeutic and prognostic methods in dental medicine, as well as new materials and procedures. Topics of interest for this Special Issue include but are not limited to the following:

  • Investigation and application of new and innovative materials in dentistry.
  • Investigation and application of new, advanced or improved technology in the prevention, diagnosis and treatment of dental and oral diseases.
  • Biomaterials and regenerative procedures in dentistry.
  • Advanced dental imaging and digital information processing.
  • Application of artificial intelligence in the dental profession.

Dr. Ivana Savić Pavičin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biocompatible materials
  • regenerative methods
  • lasers
  • dental technology
  • operative dentistry
  • preventive dentistry: dental imaging

Published Papers (7 papers)

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Research

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11 pages, 3011 KiB  
Article
Design and Implement Strategy of Wireless Bite Force Device
by Jinxia Gao, Zhiwen Su and Longjun Liu
Bioengineering 2023, 10(5), 507; https://doi.org/10.3390/bioengineering10050507 - 23 Apr 2023
Cited by 1 | Viewed by 1323
Abstract
Abnormal bite force is an important risk factor for oral and maxillofacial disorders, which is a critical dilemma that dentists face every day without effective solutions. Therefore, it is of great clinical significance to develop a wireless bite force measurement device and explore [...] Read more.
Abnormal bite force is an important risk factor for oral and maxillofacial disorders, which is a critical dilemma that dentists face every day without effective solutions. Therefore, it is of great clinical significance to develop a wireless bite force measurement device and explore quantitative measurement methods to help find effective strategies for improving occlusal diseases. This study designed the open window carrier of a bite force detection device through 3D printing technology, and then the stress sensors were integrated and embedded into a hollow structure. The sensor system mainly consisted of a pressure signal acquisition module, a main control module, and a server terminal. A machine learning algorithm will be leveraged for bite force data processing and parameter configuration in the future. This study implemented a sensor prototype system from scratch to fully evaluate each component of the intelligent device. The experimental results showed reasonable parameter metrics for the device carrier and demonstrated the feasibility of the proposed scheme for bite force measurement. An intelligent and wireless bite force device with a stress sensor system is a promising approach to occlusal disease diagnosis and treatment. Full article
(This article belongs to the Special Issue Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis)
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12 pages, 2815 KiB  
Article
Comparison of Osseointegration of Dental Implants Placed in Rabbit Tibia Using Two Dental Laser and Implant Handpiece Systems
by Jin-Han Park, Keunbada Son, Young-Tak Son, Yong-Gun Kim, Jo-Young Suh, Kyu-Bok Lee and Jae-Mok Lee
Bioengineering 2022, 9(11), 681; https://doi.org/10.3390/bioengineering9110681 - 11 Nov 2022
Cited by 1 | Viewed by 1600
Abstract
The present study aimed to confirm the usefulness of a multi-laser handpiece system currently under development. Implants were placed in the tibia of rabbits using a conventional separate laser-implant handpiece system (control group; SurgicPro+; NSK, Kanuma, Japan and Epic 10; Biolase, Irvine, CA, [...] Read more.
The present study aimed to confirm the usefulness of a multi-laser handpiece system currently under development. Implants were placed in the tibia of rabbits using a conventional separate laser-implant handpiece system (control group; SurgicPro+; NSK, Kanuma, Japan and Epic 10; Biolase, Irvine, CA, USA) and a multi-laser handpiece system (experimental group; BLP 10; Saeshin, Daegu, Korea). Implants were placed in left and right tibias of five rabbits using a conventional laser-implant handpiece system and a multi-laser handpiece system (N = 5 per group). Subsequently, micro-computed tomography (micro-CT; bone-to-implant contact evaluation), implant stability quotient (ISQ) measurement, and histological evaluations were performed to confirm the implant placement results. The independent t-test and the paired t-test were used to compare the ISQ values and the results of the two implant-laser handpiece groups (α = 0.05), respectively. No statistically significant difference in micro-CT, ISQ, and histological evaluations was observed between implant placement by the two systems (p > 0.05) except implant initial stability. The use of the multi-laser handpiece system is expected to produce the same results as a conventional separate laser-implant handpiece system with the higher implant initial stability. Additionally, it will potentially make the clinical environment more pleasant and will provide convenience for the clinicians. Full article
(This article belongs to the Special Issue Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis)
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12 pages, 1376 KiB  
Article
Impact of Age and Sex on Electrical Impedance Values in Healthy Oral Mucosa
by Kristina Horvat, Ivica Richter, Vesna Vucelić, Krešimir Gršić, Dinko Leović, Ivana Škrinjar, Ana Andabak Rogulj, Marko Velimir Grgić and Vlaho Brailo
Bioengineering 2022, 9(10), 592; https://doi.org/10.3390/bioengineering9100592 - 21 Oct 2022
Viewed by 1369
Abstract
Background: Electrical impedance (EI) is a property of all living tissues and represents the resistance to the electric current flow through a living tissue. EI depends on the structure and chemical composition of the tissue. The aim of this study was to determine [...] Read more.
Background: Electrical impedance (EI) is a property of all living tissues and represents the resistance to the electric current flow through a living tissue. EI depends on the structure and chemical composition of the tissue. The aim of this study was to determine the influence of age, sex, and electrode pressure on the EI values of healthy oral mucosa. The study involved 101 participants with healthy oral mucosa who were divided into three age groups. EI was measured in seven anatomical regions. Results: Significant differences between different age groups were found. Younger participants (20–40 years) had significantly higher EI values than the older participants (60+). Significantly higher EI values were found in women at all localisations at all measured frequencies, except on the hard palate. EI values measured with higher sub-pressure were significantly lower than values measured with lower sub-pressure at all frequencies and localisations, except the tongue dorsum, tongue border, and sublingual mucosa. Conclusions: This study found that EI values in healthy oral mucosa depend on age and sex and may also depend on the pressure of the measuring device. These factors should be kept in mind when EI is used as a diagnostic method for different oral lesions. Full article
(This article belongs to the Special Issue Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis)
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18 pages, 7667 KiB  
Article
Heparan Sulfate Glycosaminoglycan Is Predicted to Stabilize Inflammatory Infiltrate Formation and RANKL/OPG Ratio in Severe Periodontitis in Humans
by Roko Duplancic, Marija Roguljic, Darko Bozic and Darko Kero
Bioengineering 2022, 9(10), 566; https://doi.org/10.3390/bioengineering9100566 - 18 Oct 2022
Cited by 2 | Viewed by 1490
Abstract
Since chronically inflamed periodontal tissue exhibits extracellular matrix (ECM) degradation, the possible alternative to standard periodontitis treatment is to restore ECM by supplementing its components, including heparan sulfate glycosaminoglycan (HS GAG). Supplementation of the degraded ECM with synthetic derivatives of HS GAGs has [...] Read more.
Since chronically inflamed periodontal tissue exhibits extracellular matrix (ECM) degradation, the possible alternative to standard periodontitis treatment is to restore ECM by supplementing its components, including heparan sulfate glycosaminoglycan (HS GAG). Supplementation of the degraded ECM with synthetic derivatives of HS GAGs has been shown to be effective for periodontal tissue regeneration in experimental animal models of periodontitis. However, the potential of HS GAG supplementation for the treatment of periodontal disease in humans is still unknown. Here, we used a statistical model to investigate the role of HS GAG on inflammatory infiltrate formation and alveolar bone resorption in humans with severe periodontitis. The model was based on data from immunofluorescence staining (IF) of human gingiva samples, and reconstruction of a subset of HS GAG -related proteins from STRING reactome database. According to predictions, increased expression of native HS GAG might stabilize the accumulation of gingival inflammatory infiltrate (represented by the general inflammatory cell marker CD45) and alveolar bone resorption (represented by Receptor Activator of Nuclear ΚΒ ligand (RANKL) and osteoprotegerin (OPG) ratio) but could not restore them to healthy tissue levels. Therefore, supplementation of native HS GAG may be of limited benefits for the treatment of sever periodontitis in humans. Full article
(This article belongs to the Special Issue Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis)
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Review

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13 pages, 2685 KiB  
Review
Bioactive Restorative Materials Applied over Coronal Dentine—A Bibliometric and Critical Review
by Paula Maciel Pires, Thamirys da Costa Rosa, Mariana Batista Ribeiro-Lages, Maysa Lannes Duarte, Lucianne Cople Maia, Aline de Almeida Neves and Salvatore Sauro
Bioengineering 2023, 10(6), 731; https://doi.org/10.3390/bioengineering10060731 - 19 Jun 2023
Cited by 2 | Viewed by 1766
Abstract
The objective of the research was to examine the scientific literature concerning restorative materials with bioactive properties for the purpose of covering dentin. Searches were performed in various databases including MEDLINE, Scopus, Web of Science, Cochrane Library, Lilacs/BBO, and Embase. Inclusion criteria involved [...] Read more.
The objective of the research was to examine the scientific literature concerning restorative materials with bioactive properties for the purpose of covering dentin. Searches were performed in various databases including MEDLINE, Scopus, Web of Science, Cochrane Library, Lilacs/BBO, and Embase. Inclusion criteria involved studies that utilized the terms “dentin” and “bioactive”, along with “ion-releasing”, “smart materials”, “biomimetic materials” and “smart replacement for dentin”. The information extracted included the title, authors, publication year, journal and the country of affiliation of the corresponding author. The studies were categorized based on their study design, type of material, substrate, analytical method, and bioactivity. A total of 7161 records were recovered and 159 were included for data extraction. Most of the publications were in vitro studies (n = 149), testing different types of materials in sound dentine (n = 115). Most studies were published in Dental Materials (n = 29), and an increase in publications could be observed after the year 2000. Most of the articles were from the USA (n = 34), followed by Brazil (n = 28). Interfacial analysis was the most investigated (n = 105), followed by bond strength (n = 86). Bioactivity potential was demonstrated for most tested materials (n = 148). This review presents insights into the current trends of bioactive materials development, clearly showing a severe lack of clinical studies. Full article
(This article belongs to the Special Issue Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis)
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18 pages, 647 KiB  
Review
Current Applications and Future Directions of Lasers in Endodontics: A Narrative Review
by Qin Huang, Zucen Li, Ping Lyu, Xuedong Zhou and Yi Fan
Bioengineering 2023, 10(3), 296; https://doi.org/10.3390/bioengineering10030296 - 26 Feb 2023
Cited by 10 | Viewed by 6293
Abstract
The utilization of lasers has been regarded as a novel technique for the purposes of clinical use in the dental field. Recently, numerous studies have been conducted on the potential applications of laser therapy in endodontics. Moreover, due to their ablation, penetrability, and [...] Read more.
The utilization of lasers has been regarded as a novel technique for the purposes of clinical use in the dental field. Recently, numerous studies have been conducted on the potential applications of laser therapy in endodontics. Moreover, due to their ablation, penetrability, and disinfection capabilities, lasers have performed well with respect to endodontic treatments, including root canal treatment, vital pulp therapy (pulp capping and pulpotomy), dentinal hypersensitivity treatment, and management of dental pain related to pulp and periradicular disease. In particular, the superiorities of laser-aided pulp therapy are emphasized through condensed clinical controlled trials, and histological studies, in this review. Moreover, the ingenious use of laser applications with respect to aiding in the acceleration of root development and the extraction of foreign matters (i.e., broken files and fiber posts) in canals has quickly become the cutting-edge trend of current research. This review offers a summary and discussion of the current literature on all the aforementioned laser applications. Moreover, the characteristics of laser devices, including erbium lasers, neodymium-doped lasers, CO2 lasers, and diode lasers, are detailed and discussed here, providing useful references for laser application in endodontics. We also focus on the different wavelengths with respect to the lasers that are applied in endodontics. High-power lasers perform well as operative instruments; in addition, low-level lasers lead to the regulation of pulp inflammation, and the promotion of pulp healing. This narrative review provides a summary of the advanced applications of lasers in conjunction with various devices in the practice of endodontics, and aims to inspire innovative perspectives on lasers in the context of the treatment of dental diseases, especially pulp diseases, in the future. Full article
(This article belongs to the Special Issue Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis)
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18 pages, 1386 KiB  
Review
Towards a New Concept of Regenerative Endodontics Based on Mesenchymal Stem Cell-Derived Secretomes Products
by Luis A. Costa, Noemi Eiro, Andrea Vaca and Francisco J. Vizoso
Bioengineering 2023, 10(1), 4; https://doi.org/10.3390/bioengineering10010004 - 20 Dec 2022
Cited by 9 | Viewed by 3332
Abstract
The teeth, made up of hard and soft tissues, represent complex functioning structures of the oral cavity, which are frequently affected by processes that cause structural damage that can lead to their loss. Currently, replacement therapy such as endodontics or implants, restore structural [...] Read more.
The teeth, made up of hard and soft tissues, represent complex functioning structures of the oral cavity, which are frequently affected by processes that cause structural damage that can lead to their loss. Currently, replacement therapy such as endodontics or implants, restore structural defects but do not perform any biological function, such as restoring blood and nerve supplies. In the search for alternatives to regenerate the dental pulp, two alternative regenerative endodontic procedures (REP) have been proposed: (I) cell-free REP (based in revascularization and homing induction to remaining dental pulp stem cells (DPSC) and even stem cells from apical papilla (SCAP) and (II) cell-based REP (with exogenous cell transplantation). Regarding the last topic, we show several limitations with these procedures and therefore, we propose a novel regenerative approach in order to revitalize the pulp and thus restore homeostatic functions to the dentin-pulp complex. Due to their multifactorial biological effects, the use of mesenchymal stem cells (MSC)-derived secretome from non-dental sources could be considered as inducers of DPSC and SCAP to completely regenerate the dental pulp. In partial pulp damage, appropriate stimulate DPSC by MSC-derived secretome could contribute to formation and also to restore the vasculature and nerves of the dental pulp. Full article
(This article belongs to the Special Issue Recent Advances in Dental Diseases: Diagnosis, Treatment and Prognosis)
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