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Bioengineering
Special Issues
Tissue Engineering and Regenerative Medicine in Bioengineering
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Tissue Engineering and Regenerative Medicine in Bioengineering

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 30 July 2024 | Viewed by 2821

Special Issue Editors

Prof. Dr. Lynn L.H. Huang

E-Mail Website
Guest Editor
Institute of Biotechnology, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan
Interests: biomaterials and tissue engineering
Dr. Chun-Yen Liu

E-Mail Website
Guest Editor
Department of Materials Science & Engineering, National Cheng Kung University, Tainan 70101, Taiwan
Interests: tissue engineering; biomaterials; liquid crystal material; soft material; functional polymers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The human body has the natural ability to heal itself in many ways. It may take a few days to a few months or even a year for the tissue to recover based on the degree of damage. Because patients may feel uncomfortable and unpleasant during the recovery process or tissues may be unable to recover back to their original status because of seriously injury, tissue engineering materials and regenerative medicine play an important role for both medical applications and academic research fields, which has resulted in these materials raising a lot of attention over the past few decades.

Regenerative medicine is a broad field that includes tissue engineering, which is composed of three important factors: cells, scaffolds, and growth factors. With the help of tissue engineered materials, a variety of functionalized constructs can be achieved to restore, improve, assist, or even replace the biological functions of tissues or organs of patients. By combining different kinds of materials, regardless of natural or synthetic polymers, tissue engineered materials and regenerative materials possessing their own mechanical and physical properties can be achieved. With the rapid development of technology, biocompatible and biodegradable materials can be expected to be applied in medical and regenerative applications such as wound healing dressing, easing pain relief patch, drug delivery systems, cancer therapy, etc.

In this Special Issue, we focus on tissue engineering and regenerative medical materials used in the field of cellular and/or material–cellular interactions for tissue engineering and regenerative medicine. Related original articles, communications, and reviews are all welcome in this Special Issue.

Prof. Dr. Lynn L.H. Huang
Dr. Chun-Yen Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • tissue engineering
  • regenerative material
  • biomedical material
  • medical material
  • polymeric material
  • synthetic material
  • natural derivative material
  • biopolymer
  • soft material

Published Papers (2 papers)

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Research

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Article
Perfusable Tissue Bioprinted into a 3D-Printed Tailored Bioreactor System
by Marius Gensler, Christoph Malkmus, Philipp Ockermann, Marc Möllmann, Lukas Hahn, Sahar Salehi, Robert Luxenhofer, Aldo R. Boccaccini and Jan Hansmann
Bioengineering 2024, 11(1), 68; https://doi.org/10.3390/bioengineering11010068 - 09 Jan 2024
Cited by 1 | Viewed by 1657
Abstract
Bioprinting provides a powerful tool for regenerative medicine, as it allows tissue construction with a patient’s specific geometry. However, tissue culture and maturation, commonly supported by dynamic bioreactors, are needed. We designed a workflow that creates an implant-specific bioreactor system, which is easily [...] Read more.
Bioprinting provides a powerful tool for regenerative medicine, as it allows tissue construction with a patient’s specific geometry. However, tissue culture and maturation, commonly supported by dynamic bioreactors, are needed. We designed a workflow that creates an implant-specific bioreactor system, which is easily producible and customizable and supports cell cultivation and tissue maturation. First, a bioreactor was designed and different tissue geometries were simulated regarding shear stress and nutrient distribution to match cell culture requirements. These tissues were then directly bioprinted into the 3D-printed bioreactor. To prove the ability of cell maintenance, C2C12 cells in two bioinks were printed into the system and successfully cultured for two weeks. Next, human mesenchymal stem cells (hMSCs) were successfully differentiated toward an adipocyte lineage. As the last step of the presented strategy, we developed a prototype of an automated mobile docking station for the bioreactor. Overall, we present an open-source bioreactor system that is adaptable to a wound-specific geometry and allows cell culture and differentiation. This interdisciplinary roadmap is intended to close the gap between the lab and clinic and to integrate novel 3D-printing technologies for regenerative medicine. Full article
(This article belongs to the Special Issue Tissue Engineering and Regenerative Medicine in Bioengineering)
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Review

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17 pages, 1149 KiB  
Review
Regulation of Oxygen Tension as a Strategy to Control Chondrocytic Phenotype for Cartilage Tissue Engineering and Regeneration
by Mikko J. Lammi and Chengjuan Qu
Bioengineering 2024, 11(3), 211; https://doi.org/10.3390/bioengineering11030211 - 23 Feb 2024
Viewed by 901
Abstract
Cartilage defects and osteoarthritis are health problems which are major burdens on health care systems globally, especially in aging populations. Cartilage is a vulnerable tissue, which generally faces a progressive degenerative process when injured. This makes it the 11th most common cause of [...] Read more.
Cartilage defects and osteoarthritis are health problems which are major burdens on health care systems globally, especially in aging populations. Cartilage is a vulnerable tissue, which generally faces a progressive degenerative process when injured. This makes it the 11th most common cause of global disability. Conservative methods are used to treat the initial phases of the illness, while orthopedic management is the method used for more progressed phases. These include, for instance, arthroscopic shaving, microfracturing and mosaicplasty, and joint replacement as the final treatment. Cell-based implantation methods have also been developed. Despite reports of successful treatments, they often suffer from the non-optimal nature of chondrocyte phenotype in the repair tissue. Thus, improved strategies to control the phenotype of the regenerating cells are needed. Avascular tissue cartilage relies on diffusion for nutrients acquisition and the removal of metabolic waste products. A low oxygen content is also present in cartilage, and the chondrocytes are, in fact, well adapted to it. Therefore, this raises an idea that the regulation of oxygen tension could be a strategy to control the chondrocyte phenotype expression, important in cartilage tissue for regenerative purposes. This narrative review discusses the aspects related to oxygen tension in the metabolism and regulation of articular and growth plate chondrocytes and progenitor cell phenotypes, and the role of some microenvironmental factors as regulators of chondrocytes. Full article
(This article belongs to the Special Issue Tissue Engineering and Regenerative Medicine in Bioengineering)
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