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Physical Plasma in Oncology: Prevention and Treatment of Neoplastic, Premalignant and Cancer Diseases

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Physics General".

Deadline for manuscript submissions: closed (20 February 2022) | Viewed by 11621

Special Issue Editors

Prof. Dr. Martin Weiss

E-Mail Website
Guest Editor
Department of Women’s Health, Eberhard Karls University, 72076 Tübingen, Germany
Interests: cancer research; plasma medicine; cell biology; molecular biology
Special Issues, Collections and Topics in MDPI journals
Dr. Matthias Stope

E-Mail Website
Guest Editor
Department of Gynecology and Gynecological Oncology, University Hospital Bonn, 53127 Bonn, Germany
Interests: physical plasma medicine; translational molecular biology; wild life biology; veterinary research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The development of non-invasive and low-temperature plasma and research on its multiple effects on neoplastic and premalignant diseases has opened completely new medical applications within the last years. Intensive life science-based research on plasma-specific cellular and molecular efficacy has led to many innovative applications of various plasma sources in all fields of medicine. Recently, the discipline of plasma oncology has developed, in which plasma processes are being tested and applied for the prevention and therapy of neoplastic, premalignant and cancer diseases. Today, the introduction of effective preventive and oncological plasma therapies into clinical practice seems to be imminent. However, as is often the case with novel procedures, the extensive and promising in vitro data are currently being contrasted by far less preclinical and clinical data.

This special issue is intended to summarize the current status of plasma in prevention and oncology with special focus on translational and clinical research. Among application-related fields and other topics, it includes work on the following issues:

  • Non-invasive physical plasma;
  • In-vivo-like in-vitro models;
  • Clinical studies; 
  • Animal models;
  • Plasma oncology;
  • Case reports;
  • Plasma prevention;
  • Intraoperative plasma treatment;
  • Neoplasia;
  • Cancer;
  • Plasma in dentistry;
  • Plasma in veterinary medicine;
  • Clinical plasma sources

Prof. Dr. Martin Weiss
Prof. Dr. Matthias Stope
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Non-invasive physical plasma
  • In-vivo-like in-vitro models
  • Clinical studies
  • Animal models
  • Plasma oncology
  • Case reports
  • Plasma prevention
  • Intraoperative plasma treatment
  • Neoplasia
  • Cancer
  • Plasma in dentistry
  • Plasma in veterinary medicine
  • Clinical plasma sources

Published Papers (4 papers)

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11 pages, 1695 KiB  
Article
Targeted Protein Profiling of In Vivo NIPP-Treated Tissues Using DigiWest Technology
by Felix Ruoff, Melanie Henes, Markus Templin, Markus Enderle, Hans Bösmüller, Diethelm Wallwiener, Sara Y. Brucker, Katja Schenke-Layland and Martin Weiss
Appl. Sci. 2021, 11(23), 11238; https://doi.org/10.3390/app112311238 - 26 Nov 2021
Cited by 6 | Viewed by 1986
Abstract
Non-invasive physical plasma (NIPP) is a novel therapeutic tool, currently being evaluated for the treatment of cancer and precancerous lesions in gynecology and other disciplines. Additionally, patients with cervical intraepithelial neoplasia (CIN) may benefit from NIPP treatment due to its non-invasive, side-effect-free, and [...] Read more.
Non-invasive physical plasma (NIPP) is a novel therapeutic tool, currently being evaluated for the treatment of cancer and precancerous lesions in gynecology and other disciplines. Additionally, patients with cervical intraepithelial neoplasia (CIN) may benefit from NIPP treatment due to its non-invasive, side-effect-free, and tissue-sparing character. However, the molecular impact of in vivo NIPP treatment needs to be further investigated. For this purpose, usually only very small tissue biopsies are available after NIPP treatment. Here, we adapted DigiWest technology, a high-throughput bead-based Western blot, for the analysis of formalin-fixed paraffin-embedded (FFPE) cervical punch biopsies with a minimal sample amount. We investigated the molecular effects of NIPP treatment directly after (0 h) and 24 h after in vivo application. Results were compared to in vitro NIPP-treated human malignant cervical cells. NIPP effects were primarily based on an inhibitory impact on the cell cycle and cell growth factors. DigiWest technology was suitable for detailed protein profiling of small, primary FFPE biopsies. Full article
(This article belongs to the Special Issue Physical Plasma in Oncology: Prevention and Treatment of Neoplastic, Premalignant and Cancer Diseases)
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17 pages, 2804 KiB  
Article
Non-Invasive Physical Plasma Enhances the Membrane Permeability to Low Molecular Weight Compounds and Subsequently Leads to the Loss of Cellular ATP and the Devitalization of Epithelial Cancer Cells
by Caroline Sander, Andreas Nitsch, Holger H. H. Erb, Eva K. Egger, Lyubomir Haralambiev, Benedikt Eggers, Franz-Josef Kramer, Martin Weiss, Alexander Mustea and Matthias B. Stope
Appl. Sci. 2021, 11(21), 9801; https://doi.org/10.3390/app11219801 - 20 Oct 2021
Cited by 2 | Viewed by 1522
Abstract
Non-invasive physical plasma (NIPP) achieves biomedical effects primarily through the formation of reactive oxygen and nitrogen species. In clinical use, these species interact with cells of the treated tissue, affecting the cytoplasmic membrane first. The present study investigated the permeability of the cytoplasmic [...] Read more.
Non-invasive physical plasma (NIPP) achieves biomedical effects primarily through the formation of reactive oxygen and nitrogen species. In clinical use, these species interact with cells of the treated tissue, affecting the cytoplasmic membrane first. The present study investigated the permeability of the cytoplasmic membrane of breast cancer cells with different fluorescent dyes after NIPP treatment and determined the subsequent effects on cell viability. After NIPP treatment and the associated formation of reactive oxygen species, low molecular weight compounds were able to pass through the cytoplasmic membrane in both directions to a higher extent. Consequently, a loss of cellular ATP into the extracellular space was induced. Due to these limitations in cell physiology, apoptosis was induced in the cancer cells and the entire cell population exhibited decreased cell growth. It can be concluded that NIPP treatment disturbs the biochemical functionality of the cytoplasmic membrane of cancer cells, which massively impairs their viability. This observation opens a vast application horizon of NIPP therapy to treat precancerous and malignant diseases beyond breast cancer therapy. Full article
(This article belongs to the Special Issue Physical Plasma in Oncology: Prevention and Treatment of Neoplastic, Premalignant and Cancer Diseases)
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19 pages, 2529 KiB  
Article
Open-Air Cold Plasma Device Leads to Selective Tumor Cell Cytotoxicity
by Catarina Almeida-Ferreira, Rafael Silva-Teixeira, Mafalda Laranjo, Nuno Almeida, Gonçalo Brites, João Dias-Ferreira, Inês Marques, Rita Neves, Beatriz Serambeque, Ricardo Teixo, Ana Margarida Abrantes, Francisco Caramelo and Maria Filomena Botelho
Appl. Sci. 2021, 11(9), 4171; https://doi.org/10.3390/app11094171 - 2 May 2021
Cited by 13 | Viewed by 3245
Abstract
The need for effective and safe therapies for cancer is growing as aging is modifying its epidemiology. Cold atmospheric plasma (CAP) has gained attention as a potential anti-tumor therapy. CAP is a gas with enough energy to ionize a significant fraction of its [...] Read more.
The need for effective and safe therapies for cancer is growing as aging is modifying its epidemiology. Cold atmospheric plasma (CAP) has gained attention as a potential anti-tumor therapy. CAP is a gas with enough energy to ionize a significant fraction of its constituent particles, forming equal numbers of positive ions and electrons. Timely-resolved output voltage measurement, emission spectroscopy, and quantification of reactive species (RS) in plasma-activated media (PAM) were performed to characterize the physical and chemical properties of plasma. To assess the cytotoxicity of cold atmospheric plasma in human tumors, different cell lines were cultured, plated, and exposed to CAP, followed by MTT and SRB colorimetric assays 24 h later. Human fibroblasts, phenotypically normal cells, were processed similarly. Plasma cytotoxicity was higher in cells of breast cancer, urinary bladder cancer, osteosarcoma, lung cancer, melanoma, and endometrial cancer. Cytotoxicity was time-dependent and possibly related to the increased production of hydrogen peroxide in the exposed medium. Sixty seconds of CAP exposure renders selective effects, preserving the viability of fibroblast cells. These results point to the importance of conducting further studies of the therapy with plasma. Full article
(This article belongs to the Special Issue Physical Plasma in Oncology: Prevention and Treatment of Neoplastic, Premalignant and Cancer Diseases)
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12 pages, 1872 KiB  
Case Report
Non-Invasive Physical Plasma Treatment after Tooth Extraction in a Patient on Antiresorptive Medication Promotes Tissue Regeneration
by Benedikt Eggers, Matthias Bernhard Stope, Alexander Mustea, Marjan Nokhbehsaim, Nils Heim and Franz-Josef Kramer
Appl. Sci. 2022, 12(7), 3490; https://doi.org/10.3390/app12073490 - 30 Mar 2022
Cited by 2 | Viewed by 4117
Abstract
Postoperative tissue regeneration can be negatively affected by bisphosphonate administration, especially in patients with oncologic diseases. A serious complication of bisphosphonate therapy is the medication-related osteonecrosis of the jaw (MRONJ), which can be observed mainly after dental surgery. MRONJ is a progressive destruction [...] Read more.
Postoperative tissue regeneration can be negatively affected by bisphosphonate administration, especially in patients with oncologic diseases. A serious complication of bisphosphonate therapy is the medication-related osteonecrosis of the jaw (MRONJ), which can be observed mainly after dental surgery. MRONJ is a progressive destruction of the bone that requires patients to stay in hospital for extended periods of time. For this reason, primary wound closure is particularly important in surgical procedures. In the case of wound dehiscence, there is a very high risk for MRONJ. In recent years, non-invasive physical plasma (NIPP) has become known for improving wound healing on the one hand, but also for its promising efficacy in cancer therapy on the other hand. We report on a 63-year-old patient with a history of multiple myeloma and receiving zoledronate, who developed wound dehiscence after tooth extraction. NIPP treatment resulted in complete epithelialization of the entire wound dehiscence. In conclusion, the use of NIPP in patients receiving antiresorptive drugs seems to support tissue regeneration and thus could be an important tool for the prevention of MRONJ. Full article
(This article belongs to the Special Issue Physical Plasma in Oncology: Prevention and Treatment of Neoplastic, Premalignant and Cancer Diseases)
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