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Applied Sciences
Special Issues
New Challenges in Skin Cancer
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New Challenges in Skin Cancer

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 10616

Special Issue Editors

Dr. Ionut Luchian

E-Mail Website
Guest Editor
Department of Periodontology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Interests: salivary research; ortho-perio; cytokines; biomarkers; finite element method; periodontology
Special Issues, Collections and Topics in MDPI journals
Dr. Porumb-Andrese Elena

E-Mail Website
Guest Editor
Department Dermatology, ‘Grigore T. Popa’ University of Medicine and Pharmacy, 700115 Iasi, Romania
Interests: skin; basal cell carcinoma; squamous cell carcinoma; melanoma

Special Issue Information

Dear Colleagues,

It is our pleasure to announce the launch of a new Special Issue for the Applied Sciences journal.

Skin cancer is the most common malignancy in humans, and its incidence steadily increasing in recent years regardless of race, posing a growing public health challenge.

In the Special Issue, we would like to publish original skin cancer research in the molecular pathophysiology field, which could lead to a better understanding of the mechanisms underlying the neoplastic process, with the translation of possible benefits in the therapeutical field of this disease.

Our hope is that the cognitive science community will find this Special Issue to be an informative and useful collection of articles, with benefits including:

  1. Reduced overall publication times;
  2. Reduced waiting time and increased author visibility.

Therefore, we invite submissions exploring cutting-edge research and recent advances in the fields of skin and mucosal cancer.

Dr. Ionut Luchian
Dr. Porumb-Andrese Elena
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin
  • basal cell carcinoma
  • squamous cell carcinoma
  • melanoma

Published Papers (5 papers)

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Research

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8 pages, 3485 KiB  
Article
Ultrastructural Features of Keratoacanthoma—Clinical Implications
by Doinița Temelie-Olinici, Petronela Bărgăoanu, Iolanda Foia, Pavel Onofrei, Cristina Daniela Dimitriu, Ana-Emanuela Botez, Laura Stoica, Vasile-Bogdan Grecu and Elena-Carmen Cotrutz
Appl. Sci. 2022, 12(10), 5120; https://doi.org/10.3390/app12105120 - 19 May 2022
Viewed by 1218
Abstract
Over the years, keratoacanthomas have been described as some of the most common skin lesions with the potential for malignant transformation, thus constituting an important risk factor for the development of squamous cell carcinoma. The quantification of the risk of malignant transformation is [...] Read more.
Over the years, keratoacanthomas have been described as some of the most common skin lesions with the potential for malignant transformation, thus constituting an important risk factor for the development of squamous cell carcinoma. The quantification of the risk of malignant transformation is conditioned by the clinical–morphological and etiopathogenic variability of these lesions, with a negative impact on diagnostic and therapeutic management. In this sense, the main objective of this research is to characterize from an ultrastructural perspective the specific tumour microenvironment, by using a technique with a higher resolution power than photon microscopy. Keratoacanthoma lesions from 25 patients were excised from healthy tissue and then processed by classical electron microscopy and examined with the Philips CM100 microscope. The electron microscopic study revealed structural details suggestive of malignant transformation, capturing changes at both cytoplasmic and membranous levels. The identification and description of the ultrastructural morphological substrate favouring the evolution and progression of the studied lesions correlates directly with the improvement of the prognosis and quality of life of these patients. Full article
(This article belongs to the Special Issue New Challenges in Skin Cancer)
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7 pages, 220 KiB  
Article
The BRAF V600E Mutation Detection by quasa Sensitive Real-Time PCR Assay in Northeast Romania Melanoma Patients
by Elena Porumb-Andrese, Ramona Gabriela Ursu, Iuliu Ivanov, Irina-Draga Caruntu, Vlad Porumb, Dan Ferariu, Costin Damian, Delia Ciobanu, Cristina Terinte and Luminita Smaranda Iancu
Appl. Sci. 2021, 11(20), 9511; https://doi.org/10.3390/app11209511 - 13 Oct 2021
Cited by 7 | Viewed by 2318
Abstract
Background: The prevalence of melanoma in Romanian patients is underestimated. There is a need to identify the BRAF V600E mutation to accurately treat patients with the newest approved BRAF inhibitor therapy. This is a pilot study in which we first aimed to choose [...] Read more.
Background: The prevalence of melanoma in Romanian patients is underestimated. There is a need to identify the BRAF V600E mutation to accurately treat patients with the newest approved BRAF inhibitor therapy. This is a pilot study in which we first aimed to choose the optimal DNA purification method from formalin fixation and paraffin embedding (FFPE) malignant melanoma skin samples to assess the BRAF mutation prevalence and correlate it with clinical pathological parameters. Methods: 30 FFPE samples were purified in parallel with two DNA extraction kits, a manual and a semi-automated kit. The extracted DNA in pure and optimum quantity was tested for the BRAF V600E mutation using the quantitative allele-specific amplification (quasa) method. quasa is a method for the sensitive detection of mutations that may be present in clinical samples at low levels. Results: The BRAF V600E mutation was detected in 60% (18/30) samples in patients with primary cutaneous melanoma of the skin. BRAFV600E mutation was equally distributed by gender and was associated with age >60, nodular melanoma, and trunk localization. Conclusions: The high prevalence of BRAF V600E mutations in our study group raises awareness for improvements to the national reporting system and initiation of the target therapy for patients with malignant melanoma of the skin. Full article
(This article belongs to the Special Issue New Challenges in Skin Cancer)

Review

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17 pages, 1432 KiB  
Review
Liquid Biopsy and Dielectrophoretic Analysis—Complementary Methods in Skin Cancer Monitoring
by Thomas Gabriel Schreiner, Ina Turcan, Marius Andrei Olariu, Romeo Cristian Ciobanu and Maricel Adam
Appl. Sci. 2022, 12(7), 3366; https://doi.org/10.3390/app12073366 - 25 Mar 2022
Cited by 1 | Viewed by 2070
Abstract
The incidence and prevalence of skin cancers is currently increasing worldwide, with early detection, adequate treatment, and prevention of recurrences being topics of great interest for researchers nowadays. Although tumor biopsy remains the gold standard of diagnosis, this technique cannot be performed in [...] Read more.
The incidence and prevalence of skin cancers is currently increasing worldwide, with early detection, adequate treatment, and prevention of recurrences being topics of great interest for researchers nowadays. Although tumor biopsy remains the gold standard of diagnosis, this technique cannot be performed in a significant proportion of cases, so that the use of alternative methods with high sensitivity and specificity is becoming increasingly desirable. In this context, liquid biopsy appears to be a feasible solution for the study of cellular and molecular markers relevant to different types of skin cancers. Circulating tumor cells are just one of the components of interest obtained from performing liquid biopsy, and their study by complementary methods, such as dielectrophoresis, could bring additional benefits in terms of characterizing skin tumors and subsequently applying personalized therapy. One purpose of this review is to demonstrate the utility of liquid biopsy primarily in monitoring the most common types of skin tumors: basal cell carcinoma, squamous cell carcinoma, and malign melanoma. In addition, the originality of the article is based on the detailed presentation of the dielectrophoretic analysis method of the most important elements obtained from liquid biopsy, with direct impact on the clinical and therapeutic approach of skin tumors. Full article
(This article belongs to the Special Issue New Challenges in Skin Cancer)
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16 pages, 439 KiB  
Review
Molecular Profile of Skin Cancer
by Elena Porumb-Andrese, Mihaela Monica Scutariu, Ionut Luchian, Thomas Gabriel Schreiner, Ioana Mârţu, Vlad Porumb, Cosmin Gabriel Popa, Darius Sandu and Ramona Gabriela Ursu
Appl. Sci. 2021, 11(19), 9142; https://doi.org/10.3390/app11199142 - 01 Oct 2021
Cited by 10 | Viewed by 2388
Abstract
Neoplasia occurs as a result of genetic mutations. Research evaluating the association between gene mutations and skin cancer is limited and has produced inconsistent results. There are no established guidelines for screening skin cancer at molecular level. It should also be noted that [...] Read more.
Neoplasia occurs as a result of genetic mutations. Research evaluating the association between gene mutations and skin cancer is limited and has produced inconsistent results. There are no established guidelines for screening skin cancer at molecular level. It should also be noted that the combinations of some mutations may play a role in skin tumors’ biology and immune response. There are three major types of skin cancer, and the originality of this study comes from its approach of each of them. Full article
(This article belongs to the Special Issue New Challenges in Skin Cancer)
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Other

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9 pages, 2436 KiB  
Case Report
Radiotherapy and Immunotherapy, Combined Treatment for Unresectable Mucosal Melanoma with Vaginal Origin
by Laura Rebegea, Dorel Firescu, Gabriela Stoleriu, Manuela Arbune, Rodica Anghel, Mihaela Dumitru, Raul Mihailov, Anca Iulia Neagu and Xenia Bacinschi
Appl. Sci. 2022, 12(15), 7734; https://doi.org/10.3390/app12157734 - 01 Aug 2022
Cited by 2 | Viewed by 1506
Abstract
Gynecologic melanomas are uncommon and malignant mucosal melanomas with vaginal origin are extremely rare, treatment strategies are limited and extrapolated from those of cutaneous melanoma. A better understanding of the vulvovaginal melanoma’s biology and its risk factors is needed. Therapeutic strategies include surgery, [...] Read more.
Gynecologic melanomas are uncommon and malignant mucosal melanomas with vaginal origin are extremely rare, treatment strategies are limited and extrapolated from those of cutaneous melanoma. A better understanding of the vulvovaginal melanoma’s biology and its risk factors is needed. Therapeutic strategies include surgery, systemic therapy and radiotherapy. For vulvovaginal melanoma, surgery is selected as the primary treatment. Immunotherapy and target treatment have recently enhanced the systemic therapy for cutaneous melanoma (CM). Immunotherapy and new target agents demonstrated a better survival of melanoma and might be considered as treatment of vulvovaginal melanoma. Radiotherapy is included in the therapeutic arsenal for mucosal melanoma and may be performed on selected patients who may receive concurrent checkpoints and inhibition neoadjuvant radiotherapy with the purpose of reducing morbidity and mortality. Full article
(This article belongs to the Special Issue New Challenges in Skin Cancer)
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