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Applied Sciences
Special Issues
Biomedical Applications of Supramolecular Chemistry
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Biomedical Applications of Supramolecular Chemistry

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: closed (10 June 2022) | Viewed by 3370

Special Issue Editors

Dr. Mario Inclán

E-Mail Website
Guest Editor
Molecular Science Institute (ICMol), University of Valencia, 46010 Valencia, Spain
Interests: supramolecular chemistry; nanotechnology; biomedical applications; antimicrobial resistance
Dr. Begoña Verdejo

E-Mail Website
Guest Editor
Molecular Science Institute (ICMol), University of Valencia, 46010 Valencia, Spain
Interests: supramolecular chemistry; biomedical applications; enzyme mimics, anion recognition

Special Issue Information

Dear Colleagues,

Supramolecular chemistry has always found a source of inspiration in living systems. This should not come as a surprise, because cellular processes rely heavily on no-covalent interactions which organisms have perfected over the course of millions of years of evolution. Although we cannot yet compete with the beautiful complexity of biological systems, the knowledge acquired in the past decades regarding the non-covalent interactions of biomolecules with synthetic ligands, supramolecular assemblies and nanoparticles, has led to a wide range of biomedical applications. In a time when society is demanding new solutions to health challenges (e.g. respiratory infectious diseases, antimicrobial resistance, cancer and neurological disorders) supramolecular chemistry might have a lot to say. This is the driving force behind this Special Issue.

The suggested topics are:

  • Non-covalent interaction of synthetic systems with biomolecules and biomedical relevant compounds (nucleic acids, proteins, neurotransmitters, carbohydrates, toxins, etc.).
  • Supramolecular systems applied to bioimaging techniques.
  • Chemosensors for biomedically important metal cations and anions.
  • Interactions of metal complexes (e.g. platinum, ruthenium, iridium, etc.) with biological substrates.
  • Biomedical applications of nanoparticles and supramolecular polymers.

Dr. Mario Inclán
Dr. Begoña Verdejo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • supramolecular chemistry
  • biomedical applications
  • nanotechnology
  • chemosensors
  • bioimaging techniques
  • metal complexes
  • biomolecules
  • supramolecular polymers
  • supramolecular gels

Published Papers (2 papers)

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Research

12 pages, 1298 KiB  
Article
Substitution to Position Number 2 of 4(3H)-Quinazolinone to Create New Derivatives and to Test the Antibacterial or Antifungal Effects
by Huu Tam Tran, Oanh Nhu Thi Vu, Thuy Nhu Thi Le, Bao Dam Chau Nguyen and Ngoc Nguyen Vo
Appl. Sci. 2022, 12(5), 2710; https://doi.org/10.3390/app12052710 - 05 Mar 2022
Viewed by 1166
Abstract
The campaign “No action today, no cure tomorrow” against antimicrobial resistance proposed by the World Health Organization (WHO) has not only propeled people to take action to prevent antimicrobial resistance, but has also encouraged researchers to develop new antimicrobial agents. 4(3H)-quinazolinone [...] Read more.
The campaign “No action today, no cure tomorrow” against antimicrobial resistance proposed by the World Health Organization (WHO) has not only propeled people to take action to prevent antimicrobial resistance, but has also encouraged researchers to develop new antimicrobial agents. 4(3H)-quinazolinone and its derivatives belong to a group of compounds with many potential applications; this study was conducted to find new derivatives of heterocyclic 4(3H)-quinazolinone with biological effects, contributing to research on antibacterial and antifungal compounds. Using the closed-loop method between anthranilic acid and acetic anhydride, followed by reaction with aniline derivatives, a substituted product of position 3 of 4(3H)-quinazolinone was obtained, along with bromizing to replace the hydrogen of the methyl group in position 2 with dibromo. Heterocyclic derivatives such as imidazole, triazole, and thiazole were replaced from this dibromo product to obtain 19 derivatives. The structures of these derivatives were checked by modern methods such as IR, 1H-NMR, and MS. The results indicated that all of the structures were as expected, so the process of creating new derivatives from 4(3H)-quinazolinone was achieved in this study. Fourteen of the derivatives, namely 3d, 3e, 3f, 3g, 3h, 3i, 3j, 3k, 3m, 3o, 3p, 3q, 3r, and 3s, had antibacterial or antifungal effects. Among these, there were five potential derivatives: Antifungal activity was observed on A. niger by 3j and 3f (MIC: 32 μg/mL) and 3s (MIC: 64 μg/mL), and on C. albicans by 3f (MIC: 8 μg/mL); antibacterial activity was observed on S. aureus by 3p (MIC: 16 μg/mL) and 3f and 3r (MIC: 32 μg/mL), on MRSA by 3f and 3r (MIC: 32 μg/mL), and on E. coli by 3f (MIC: 32 μg/mL). Full article
(This article belongs to the Special Issue Biomedical Applications of Supramolecular Chemistry)
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9 pages, 1070 KiB  
Article
Mn(II) Complexes of Enlarged Scorpiand-Type Azamacrocycles as Mimetics of MnSOD Enzyme
by Mario Inclán, María Teresa Albelda, Salvador Blasco, Carolina Serena, Javier Ugarte Chicote, Antonio García-España and Enrique García-España
Appl. Sci. 2022, 12(5), 2447; https://doi.org/10.3390/app12052447 - 26 Feb 2022
Viewed by 1321
Abstract
Living organisms depend on superoxide dismutase (SOD) enzymes to shield themselves from the deleterious effects of superoxide radical. In humans, alterations of these protective mechanisms have been linked to the pathogenesis of many diseases. However, the therapeutic use of the native enzyme is [...] Read more.
Living organisms depend on superoxide dismutase (SOD) enzymes to shield themselves from the deleterious effects of superoxide radical. In humans, alterations of these protective mechanisms have been linked to the pathogenesis of many diseases. However, the therapeutic use of the native enzyme is hindered by, among other things, its high molecular size, low stability, and immunogenicity. For this reason, synthetic SOD mimetic compounds of low molecular weight may have therapeutic potential. We present here three low-molecular-weight compounds, whose Mn2+ complexes can mimic, at least partially, the protective activity of SOD-enzymes. These compounds were characterized by NMR, potentiometry, and, to test whether they have protective activity in vitro, by their capacity to restore the growth of SOD-deficient strains of E. coli. In this report, we provide evidence that these compounds form stable complexes with Mn2+ and have an in vitro protective effect, restoring up to 75% the growth of the SOD-deficient E. coli. Full article
(This article belongs to the Special Issue Biomedical Applications of Supramolecular Chemistry)
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