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Drug Discovery and Biochemical Mechanisms

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (20 May 2024) | Viewed by 954

Special Issue Editors

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Guest Editor
Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 4000 Plovdiv, Bulgaria
Interests: synthesis; drug discovery; medicinal chemistry; heterocyclic compounds; organic synthesis; hybrid molecules; small molecule synthesis; reagents; nanoparticles; microbiology

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Guest Editor
Department of Chemistry, Faculty of Pharmacy, Medical University, 1000 Sofia, Bulgaria
Interests: synthesis; organic and medical chemistry; IR and Raman spectroscopy; X-ray analysis; chemistry and spectroscopy of amino acids; peptides; Pt- and Pd- complexes; quantum chemistry

Special Issue Information

Dear Colleagues,

Researchers from academic institutions and pharmaceutical companies are always working toward the goal of discovering new medicines. The drug discovery area involves many different disciplines, such as biology, chemistry, pharmacology, biochemistry, and biotechnology. Numerous factors, such as toxicity, effectiveness, physicochemical characteristics, and bio/synthetic availability, may contribute to this challenge. Due to these factors, a constant goal is to find novel molecules with high potency and fewer negative effects.

This Special Issue, "Drug discovery and biochemical mechanism", will concentrate on the synthesis and/or biological effects of novel compounds created using medicinal chemistry methods, to improve activities against a variety of diseases, to understand the molecular mechanisms underlying life processes and disease from the protein structure to the signaling networks, and, finally, to apply this knowledge for creating new medications and therapies.  Review (focused on the last ten years’ developments.) and research articles on related topics are welcomed. 

Dr. Stoyanka A. Nikolova
Dr. Emiliya Demireva Cherneva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • drug design and discovery
  • biotechnology
  • drug screening
  • novel nonclinical models/approaches
  • in silico laboratory and clinical development
  • virtual screening
  • biochemical mechanism

Published Papers (1 paper)

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4 pages, 206 KiB  
Drug Discovery
by Stoyanka Nikolova
Appl. Sci. 2023, 13(22), 12378; - 16 Nov 2023
Viewed by 611
More than 50% of deaths worldwide are linked to chronic inflammatory disorders, including cancer, cardiovascular disease, dementia, stroke, and diabetes [...] Full article
(This article belongs to the Special Issue Drug Discovery and Biochemical Mechanisms)
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