Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.5
2.7
Journals
Applied Sciences
Special Issues
Stents and Interventional Devices: Bioengineering and Biomedical Applications
share announcement

Stents and Interventional Devices: Bioengineering and Biomedical Applications

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (25 July 2022) | Viewed by 16486

Special Issue Editor

Dr. Jung-Hoon Park

E-Mail Website
Guest Editor
Biomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea
Interests: stents; nanomedicine; drug delivery; biomedical engineering; interventional radiology; gastroenterology

Special Issue Information

Dear Colleagues,

This Special Issue on “Stents and Interventional Devices: Bioengineering and Biomedical Applications” is designed for scientific findings in the development of a variety of interventional devices, including multifunctional and creative stents and catheters based on clinical unmet needs.  

Various stents have rapidly evolved from rigid plastic tubes to flexible metallic or biodegradable stents. Stents have been used for the treatment of luminal obstructions including vascular and non-vascular, including the digestive, respiratory, and urinary system by minimally-invasive procedures using medical imaging guidance. Multifunctional stents have been investigated for reduction of stent-related complications and/or localized therapy using anticancer drugs, application of various nanoparticles, and stent surface modifications.

The transcatheter treatment offers advantages over surgical intervention in rapid recovery time and lower procedural risk. Various functional catheters have been developed for the drainage, administration of anticancer drugs or embolic materials, and access by surgical instruments.

In this Special Issue, we encourage the submissions of original research and comprehensive reviews focused on stents and interventional devices-related research.

Dr. Jung-Hoon Park
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Multifunctional stent
  • Nano functionalized stent
  • Drug-eluting stent
  • Biomedical application
  • Interventional device
  • Biomedical engineering
  • Nonvascular stent
  • Functional catheter
  • Embolization

Published Papers (6 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

8 pages, 2902 KiB  
Article
Occlusive Properties of Transrenal Ureteral Occlusion Self-Expandable Metallic Stents: 3D-Printed Phantom and Ex Vivo Studies
by Ji Won Kim, Hee Ho Chu, Dong-Sung Won, Chu Hui Zeng, Song Hee Kim, Yubeen Park, Jeon Min Kang, Dae Sung Ryu, Ji Hoon Shin and Jung-Hoon Park
Appl. Sci. 2022, 12(3), 1516; https://doi.org/10.3390/app12031516 - 30 Jan 2022
Viewed by 1996
Abstract
Newly developed transrenal ureteral occlusion self-expanding metallic stents (SEMSs) are applied in patients with inoperable fistulas. In this study, the occlusive properties of M- and D-type occlusion SEMSs were investigated in 3D-printed phantom and ex vivo porcine urinary tracts. In the former, the [...] Read more.
Newly developed transrenal ureteral occlusion self-expanding metallic stents (SEMSs) are applied in patients with inoperable fistulas. In this study, the occlusive properties of M- and D-type occlusion SEMSs were investigated in 3D-printed phantom and ex vivo porcine urinary tracts. In the former, the mean bursting pressure causing leakage of contrast medium through the occlusion SEMS was relatively higher in M-types (42.8 ± 3.8 mmHg) than in D-types (38.8 ± 3.8 mmHg), without a statistical difference (p = 0.075). In the latter, the bursting pressure causing leakage through the M-type occlusion SEMS (110.7 ± 8.6 mmHg) was significantly higher than that of the D-type occlusion SEMS (93.8 ± 11.2 mmHg, p = 0.015); however, the mean bursting pressures causing contrast blowout did not differ between the two types (178.7 ± 11.2 mmHg vs. 176.2 ± 11.8 mmHg, p = 0.715). In conclusion, M- and D-type occlusion SEMSs showed similar efficacy in occlusive properties in the 3D phantom study; however, the M-type was superior in the ex vivo porcine urinary tract model. Further in vivo experimental studies are required to confirm these experimental results. Full article
(This article belongs to the Special Issue Stents and Interventional Devices: Bioengineering and Biomedical Applications)
►▼ Show Figures

Figure 1

13 pages, 2531 KiB  
Article
Characterizing the Mechanical Performance of a Bare-Metal Stent with an Auxetic Cell Geometry
by Sukhwinder K. Bhullar, Huseyin Lekesiz, Ahmet Abdullah Karaca, Yonghyun Cho, Stephanie Michelle Willerth and Martin B. G. Jun
Appl. Sci. 2022, 12(2), 910; https://doi.org/10.3390/app12020910 - 17 Jan 2022
Cited by 11 | Viewed by 3167
Abstract
This study develops and characterizes the distinctive mechanical features of a stainless-steel metal stent with a tailored structure. A high-precision femtosecond laser was used to micromachine a stent with re-entrant hexagonal (auxetic) cell geometry. We then characterized its mechanical behavior under various mechanical [...] Read more.
This study develops and characterizes the distinctive mechanical features of a stainless-steel metal stent with a tailored structure. A high-precision femtosecond laser was used to micromachine a stent with re-entrant hexagonal (auxetic) cell geometry. We then characterized its mechanical behavior under various mechanical loadings using in vitro experiments and through finite element analysis. The stent properties, such as the higher capability of the stent to bear upon bending, exceptional advantage at elevated levels of twisting angles, and proper buckling, all ensured a preserved opening to maintain the blood flow. The outcomes of this preliminary study present a potential design for a stent with improved physiologically relevant mechanical conditions such as longitudinal contraction, radial strength, and migration of the stent. Full article
(This article belongs to the Special Issue Stents and Interventional Devices: Bioengineering and Biomedical Applications)
►▼ Show Figures

Figure 1

9 pages, 2951 KiB  
Article
Interwoven versus Knitted Self-Expandable Metallic Stents: A Comparison Study of Stent-Induced Tissue Hyperplasia in the Rat Esophagus
by Jeon Min Kang, Dongwook Oh, Song Hee Kim, Dae Sung Ryu, Yubeen Park, Dong-Sung Won, Ji Won Kim, Chu Hui Zeng, Jung-Hoon Park and Sang Soo Lee
Appl. Sci. 2022, 12(1), 346; https://doi.org/10.3390/app12010346 - 30 Dec 2021
Cited by 1 | Viewed by 1821
Abstract
This study investigated whether interwoven self-expandable metallic stent (I-SEMS) placement suppresses stent-induced tissue hyperplasia compared with conventional knitted self-expandable metallic stent (K-SEMS) placement in a rat esophageal model. Twelve rats were randomly assigned to the I-SEMS (n = 6) and K-SEMS (n = [...] Read more.
This study investigated whether interwoven self-expandable metallic stent (I-SEMS) placement suppresses stent-induced tissue hyperplasia compared with conventional knitted self-expandable metallic stent (K-SEMS) placement in a rat esophageal model. Twelve rats were randomly assigned to the I-SEMS (n = 6) and K-SEMS (n = 6) groups. All rats were sacrificed 4 weeks after the stent placement. The degree of stent-induced tissue hyperplasia on esophagography and histologic examination was compared between the groups. Stent placement was technically successful in all rats. Esophagography revealed significantly greater mean luminal diameter of the stented esophagus in the I-SEMS group than in the K-SEMS group (p < 0.001). Histologic examination revealed a significantly lower percentage of tissue hyperplasia area and a significantly thinner submucosal fibrosis in the I-SEMS group than in the K-SEMS group (all p < 0.001). There were no significant differences in the thickness of the epithelial layers (p = 0.290) and degree of inflammatory cell infiltration (p = 0.506). Formation of stent-induced tissue hyperplasia was evident with both I-SEMS and K-SEMS. Placement of I-SEMSs with a small cell size and high flexibility seems to be effective in suppressing stent-induced tissue hyperplasia compared with placement of K-SEMSs in rat esophageal models. Full article
(This article belongs to the Special Issue Stents and Interventional Devices: Bioengineering and Biomedical Applications)
►▼ Show Figures

Figure 1

11 pages, 46034 KiB  
Article
Feasibility of a Drug-Releasing Radiofrequency Ablation System in a Porcine Liver Model
by Young Chul Cho, Ki Baek Lee, Su Jung Ham, Jin Hwa Jung, Yubeen Park, Dong-Sung Won, Kyung Won Kim and Jung-Hoon Park
Appl. Sci. 2021, 11(18), 8301; https://doi.org/10.3390/app11188301 - 07 Sep 2021
Viewed by 4278
Abstract
The objective of this study was to investigate the feasibility of a newly developed anticancer drug-releasing radiofrequency ablation (RFA) system in a porcine liver model. A 15-gauge drug-releasing cooled wet electrode (DRCWE) was newly developed to improve the RFA efficacy for creating a [...] Read more.
The objective of this study was to investigate the feasibility of a newly developed anticancer drug-releasing radiofrequency ablation (RFA) system in a porcine liver model. A 15-gauge drug-releasing cooled wet electrode (DRCWE) was newly developed to improve the RFA efficacy for creating a large ablation as well as for simultaneously delivering an anticancer drug to the tumor margin. Nine ablations in three pigs were performed by the DRCWE. The sectioned liver specimens were evaluated by measuring the ablation zone by a positron emission tomography/magnetic resonance imaging examination to investigate whether 18F-fluorodeoxyglucose was exactly diffused. Volumes of the ablation zones released drug injection volumes, circularity, retention rate defined as the ratio between an estimated and injection dose, and the standard uptake value were assessed. The drug-releasing RFA was technically successful without procedural-related complications. During the procedure, the color changes of the ablated zones of the liver were observed in all specimens. The mean drug injection volume was higher than the ablated volumes (17.21 ± 2.85 vs. 15.22 ± 2.30 cm3) and the circularity was 0.72 ± 0.08. Moreover, the retention rate was 72.89% ± 4.22% and the mean standard uptake value was 0.44 ± 0.05. The drug-releasing RFA system was feasible not only for local ablation but also for the delivery of anticancer drugs. The results of this study indicate that this novel strategy of localized RFA with a drug delivery system could be a promising option for the prevention of local recurrence rates. Full article
(This article belongs to the Special Issue Stents and Interventional Devices: Bioengineering and Biomedical Applications)
►▼ Show Figures

Figure 1

10 pages, 6778 KiB  
Article
Antimigration Effects of the Number of Flaps on a Plastic Stent: Three-Dimensionally Printed Pancreatic Phantom and Ex Vivo Studies
by Dae-Sung Ryu, Joon-Myeong Choi, Woo-Jin Kim, Jeon-Min Kang, Ki-Baek Lee, Yu-Been Park, Dong-Sung Won, Ji-Won Kim, Song-Hee Kim, Pyeong-Hwa Kim, Song-Cheol Kim and Jung-Hoon Park
Appl. Sci. 2021, 11(11), 4830; https://doi.org/10.3390/app11114830 - 25 May 2021
Viewed by 1701
Abstract
Stent migration is a significant obstacle to successful stent placement. There has been no investigation of the effect and quantitative interpretation of flaps attached to a plastic stent (PS) on antimigration. The antimigration effects of the number of flaps on a PS in [...] Read more.
Stent migration is a significant obstacle to successful stent placement. There has been no investigation of the effect and quantitative interpretation of flaps attached to a plastic stent (PS) on antimigration. The antimigration effects of the number of flaps on a PS in a 3D-printed pancreatic phantom (3DP) and extracted porcine pancreas (EPP) were investigated. Four PS types were used in this study: stent without flaps (type 1), stent with two flaps (type 2), stent with four horizontally made flaps (type 3), and stent with four vertically made flaps (type 4). The stents were measured and compared for antimigration force (AMF) in the 3DP and EPP using a customized measuring method and an integrated measuring device. The mean maximum AMFs (MAMFs) in types 2, 3, and 4 were significantly higher than that in type 1 (all p < 0.001). Moreover, the mean MAMFs in types 3 and 4 were significantly higher than that in type 2 (all p < 0.001). When the flaps were removed from the pancreatic duct, the AMF decreased rapidly. As the number of flaps increased, the antimigration effects significantly increased in the 3DP and EPP. However, the direction of the flaps did not affect the MAMF. The position of the flaps attached to the surface of the stent affected the AMF. Full article
(This article belongs to the Special Issue Stents and Interventional Devices: Bioengineering and Biomedical Applications)
►▼ Show Figures

Figure 1

10 pages, 3614 KiB  
Article
Technical Feasibility and Histological Analysis of Balloon-Expandable Metallic Stent Placement in a Porcine Eustachian Tube
by Yehree Kim, Woo Seok Kang, Jeon Min Kang, Dae Sung Ryu, Min Young Kwak, Ho-Young Song, Jung-Hoon Park and Hong Ju Park
Appl. Sci. 2021, 11(4), 1359; https://doi.org/10.3390/app11041359 - 03 Feb 2021
Cited by 5 | Viewed by 2531
Abstract
There is a clinical need to develop a stent to treat obstructive and refractory Eustachian tube dysfunction (ETD) after balloon Eustachian tuboplasty. An animal model for stent placement in the Eustachian tube (ET) is needed to develop optimal designs and materials, as stents [...] Read more.
There is a clinical need to develop a stent to treat obstructive and refractory Eustachian tube dysfunction (ETD) after balloon Eustachian tuboplasty. An animal model for stent placement in the Eustachian tube (ET) is needed to develop optimal designs and materials, as stents for ETD have not been clinically applied. The purpose of this study was to evaluate the technical feasibility of stent placement and histological changes in a porcine ET model. Six ETs were evaluated in three pigs. Cobalt–chrome alloy stents with two different diameters were placed in the left and right ET of each animal (right, 3.5 mm; left, 2.5 mm). The outcomes were assessed by endoscopic and fluoroscopic imaging during the procedure, computed tomography after the procedure, and by histological examinations. Stent placement was technically successful in all specimens after metallic guiding sheaths were located in the nasopharyngeal end of the ET. The mean luminal diameters of the proximal, middle, and distal portions of the larger stents in the right ETs were 3.48 mm, 2.54 mm, and 2.15 mm, respectively. In the left ETs using smaller stents, these values were 2.49 mm, 1.73 mm, and 1.42 mm, respectively. The diameters of the inserted stents differed by stent location and the original diameter. Histological findings showed tissue hyperplasia with severe inflammatory cell infiltration at 4 weeks after stent placement. In conclusion, stent placement into the porcine ET was technically feasible, and stent-induced tissue hyperplasia was significantly evident. The luminal configuration of the placed ET stent changed according to its non-elastic nature and anatomical features of the porcine ET. Using this model, ET stents of various materials and designs with anti-inflammatory or anti-proliferative drugs can be optimized for future treatments of ET dysfunction. Full article
(This article belongs to the Special Issue Stents and Interventional Devices: Bioengineering and Biomedical Applications)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-6
Back to TopTop