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Applied Sciences
Special Issues
Smart Biomaterials for Tissue Regeneration
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Smart Biomaterials for Tissue Regeneration

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 4398

Special Issue Editor

Prof. Dr. Yin Xiao

E-Mail Website1 Website2
Guest Editor
Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia
Interests: biomaterials; stem cells; tissue engineering; regenerative medicine; inflammation and tissue repair and regeneration; regenerative dentistry; bone and cartilage regeneration
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is our pleasure to announce that Applied Sciences invites submissions to this Special Issue on Smart Biomaterials for Tissue Regeneration.

Regenerative medicine aims to develop potential clinical interventions to restore the tissue function and tissue integrity for damaged or lost tissues caused by injuries, diseases, congenital defects, etc. However, tranditional development of biomaterials for tissue regeneration mostly emphasizes the regulation of stem cell function, delivery of cytokines, and support of tissue structures. Less attention is paid on the individual miroenvironment of the damaged tissues, which is significantly different between patients and influenced substantially by the health status of the patient, such as patient’s age, systematic disorders, immunocompromised condition, etc. Therefore, the next generation of smart biomaterials for tissue regeneration should not only satisfy biocompatibility, minimal inflammatory reactivity, and easy integration with the host tissue, but should also be able to sense and respond to the diverse microenvironment when implanted into different patients’ defective sites to induce desired tissue responses, leading to tissue regeneration.

In this Special Issue, we encourage submissions of original research works and reviews focused on smart biomaterials development for tissue regeneration, particularly on designing environmental response biomaterials.

Prof. Dr. Yin Xiao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Tissue regeneration
  • Microenvironment
  • Cell–material interactions
  • Smart biomaterials
  • Composites
  • Environmental response materials
  • Inflammation
  • Tissue fomation

Published Papers (1 paper)

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Review

32 pages, 4391 KiB  
Review
Four-Dimensional (Bio-)printing: A Review on Stimuli-Responsive Mechanisms and Their Biomedical Suitability
by Pedro Morouço, Bahareh Azimi, Mario Milazzo, Fatemeh Mokhtari, Cristiana Fernandes, Diana Reis and Serena Danti
Appl. Sci. 2020, 10(24), 9143; https://doi.org/10.3390/app10249143 - 21 Dec 2020
Cited by 25 | Viewed by 4044
Abstract
The applications of tissue engineered constructs have witnessed great advances in the last few years, as advanced fabrication techniques have enabled promising approaches to develop structures and devices for biomedical uses. (Bio-)printing, including both plain material and cell/material printing, offers remarkable advantages and [...] Read more.
The applications of tissue engineered constructs have witnessed great advances in the last few years, as advanced fabrication techniques have enabled promising approaches to develop structures and devices for biomedical uses. (Bio-)printing, including both plain material and cell/material printing, offers remarkable advantages and versatility to produce multilateral and cell-laden tissue constructs; however, it has often revealed to be insufficient to fulfill clinical needs. Indeed, three-dimensional (3D) (bio-)printing does not provide one critical element, fundamental to mimic native live tissues, i.e., the ability to change shape/properties with time to respond to microenvironmental stimuli in a personalized manner. This capability is in charge of the so-called “smart materials”; thus, 3D (bio-)printing these biomaterials is a possible way to reach four-dimensional (4D) (bio-)printing. We present a comprehensive review on stimuli-responsive materials to produce scaffolds and constructs via additive manufacturing techniques, aiming to obtain constructs that closely mimic the dynamics of native tissues. Our work deploys the advantages and drawbacks of the mechanisms used to produce stimuli-responsive constructs, using a classification based on the target stimulus: humidity, temperature, electricity, magnetism, light, pH, among others. A deep understanding of biomaterial properties, the scaffolding technologies, and the implant site microenvironment would help the design of innovative devices suitable and valuable for many biomedical applications. Full article
(This article belongs to the Special Issue Smart Biomaterials for Tissue Regeneration)
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