Synthesis and Biological Activity of Novel Complexes

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 2029

Special Issue Editors


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Guest Editor
Associate Professor, Department of General and Inorganic Chemistry with Methodology of Chemistry Education, Faculty of Chemistry, University of Plovdiv, 4000 Plovdiv, Bulgaria
Interests: metal complexes; coordination compounds, experimental studies; structural characterization; biological properties; antibacterial activities; cytotoxicity; anticancer

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Guest Editor
Associate Professor, Faculty of Chemistry and Pharmacy, Sofia University, 1164 Sofia, Bulgaria
Interests: bioinorganic and coordination chemistry; supramolecular chemistry; computational chemistry; spectroscopy

Special Issue Information

Dear Colleagues,

We are inviting submissions to this Special Issue on the Synthesis and Biological Activity of Novel Complexes.

In recent years, cancer has been a global scourge of modern society. Various organic compounds play a crucial role in the treatment of numerous metabolic disorders in addition to their extensive use as anti-inflammatory fenamates. They also have intriguing antibacterial, antiviral, and insecticidal capabilities, as well drug resistance in cancer cells. The transition metal complexes of, e.g., anthranilic acid derivatives, hydantoins, spirohydantoins, uracil derivatives or different organic compounds with biological activities, offer therapeutic implications in obesity and diabetes mellitus by regulating glucosidase, anticancer, antibacterial, and antioxidant activity or other biological propеrties. In particular, platinum complexes have been the focus of research since the discovery of the cancerostatica antitumor properties of cisplatin by Rosenberg. Pt(IV) complexes have attracted significant attention due to both their kinetic inertness and the resulting possibility of oral administration.

This Special Issue will focus on the synthesis, characterization, and investigation of antibacterial and antitumor activity and/or cytotoxicity, as well as the antiproliferative effect of new coordination compounds.

Distinguished researchers are encouraged to present their studies concerning coordination compounds with biomolecules and bioligands, novel metal complexes with potential biological activity (antibacterial, anticancer or cytotoxic properties), as well as new methods for synthesis.

It is our pleasure to invite you to submit your research to this Special Issue, “Synthesis and Biological Activity of Novel Complexes for the journal Applied Sciences (ISSN 2076-3417, https://www.mdpi.com/journal/applsci).” Research articles, short communications and review papers are welcome.

Dr. Petja Marinova
Dr. Anife Ahmedova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal complexes
  • coordination compounds
  • biological activity
  • antibacterial
  • anticancer

Published Papers (2 papers)

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Editorial

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3 pages, 188 KiB  
Editorial
Synthesis and Biological Activity of Novel Complexes with Anthranilic Acid and Its Analogues
by Petja Marinova and Mariyan Hristov
Appl. Sci. 2023, 13(16), 9426; https://doi.org/10.3390/app13169426 - 19 Aug 2023
Viewed by 973
Abstract
Anthranilic acid analogues and their derivatives hold significant therapeutic potential for crafting designed compounds aimed at regulating cancer-causing pathways and addressing metabolic challenges linked to diabetes, antiviral agents [...] Full article
(This article belongs to the Special Issue Synthesis and Biological Activity of Novel Complexes)

Research

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18 pages, 2422 KiB  
Article
Synthesis, Characterization, and Antibacterial Studies of New Cu(II) and Pd(II) Complexes with 6-Methyl-2-Thiouracil and 6-Propyl-2-Thiouracil
by Petya Marinova, Mariyan Hristov, Slava Tsoneva, Nikola Burdzhiev, Denica Blazheva, Aleksandar Slavchev, Evelina Varbanova and Plamen Penchev
Appl. Sci. 2023, 13(24), 13150; https://doi.org/10.3390/app132413150 - 11 Dec 2023
Viewed by 719
Abstract
The aim of the present study is to synthesize new metal complexes of 6-methyl-2-thiouracil and 6-propyl-2-thiouracil, elucidate their structures, and investigate their biological properties. All metal complexes were obtained after mixing water solutions of the corresponding metal salts and the ligand dissolved in [...] Read more.
The aim of the present study is to synthesize new metal complexes of 6-methyl-2-thiouracil and 6-propyl-2-thiouracil, elucidate their structures, and investigate their biological properties. All metal complexes were obtained after mixing water solutions of the corresponding metal salts and the ligand dissolved in DMSO and water solutions of NaOH in a metal-to-ligand ratio of 1:4:2. The structures of the new compounds are discussed based on melting point analysis (MP-AES) for Cu and Pd, UV-Vis, IR, ATR, 1H NMR, 13C NMR, and Raman spectroscopy. The interpretation of complex spectra is assisted by the data for 6-methyl-2-thiouracil and 6-propyl-2-thiouracil obtained from 1H-1H COSY, DEPT-135, HMBC and HMQC spectra. In addition, the antimicrobial activity of these complexes and the free ligands are assessed against both Gram-positive and Gram-negative bacteria, as well as yeasts. In general, the addition of metal ions improved the antimicrobial activity of both 6-methyl-2-thiouracil and 6-propyl-2-thiouracil. The Cu(II) complex with 6-methyl-2-thiouracil and the Pd(II) complex with 6-propyl-2-thiouracil exhibited the highest activity against the test microorganisms. Full article
(This article belongs to the Special Issue Synthesis and Biological Activity of Novel Complexes)
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