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Medical Image Analysis: From Small Size Data to Big Data

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Optics and Lasers".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 7077

Special Issue Editors


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Guest Editor
Computer Science Department, City University of New York, New York, NY 10314, USA
Interests: AI in medicine; biomedical data mining; object recognition; signal processing; computer-aided food quality inspection; 3D imaging visible and thermal sensors
Special Issues, Collections and Topics in MDPI journals
College of Computing, Michigan Technological University, Houghton, MI, USA
Interests: biomedical image analysis and biomedical imaging, computer aided cancer detection, biometrics, computer vision, and image understanding
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,  

A huge amount of medical image data is being created by different medical imaging devices and creating great demand for more effective algorithms to analyze and process them. Extraction of useful information from these data can bring great benefits for medical diagnosis and treatment. However, owing to the limitations of computing power, research on medical image data analysis and processing was mainly focused on small-size or middle-size image data sets in the past. With the development of GPU technology and certain other parallel computing platforms (i.e., Hadoop), the analysis and processing of big medical image data sets is now becoming a new research direction. This Special Issue will focus on recent advances on medical image processing techniques, especially techniques for big medical image data analysis and processing, and we hope that through this publication, we can push the research of image processing in health applications.

Topics of interest include (but are not limited to):

  • Deep learning for the analysis of big image data;
  • Large learning networks for medical image analysis;
  • 3D medical image analysis;
  • Image analysis techniques including segmentation, registration, quality enhancement, etc.;
  • Image analysis for oncology;
  • High-accuracy computer-aided detection and diagnosis systems with medical imaging.

Prof. Sos Agaian
Dr. Jim Tang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Deep learning for the analysis of big image data
  • Large learning networks for medical image analysis
  • 3D medical image analysis
  • Image analysis techniques including segmentation, registration, quality enhancement, etc.
  • Image analysis for oncology
  • High-accuracy computer-aided detection and diagnosis systems with medical imaging

Published Papers (3 papers)

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Research

20 pages, 19740 KiB  
Article
C3VFC: A Method for Tracing and Quantification of Microglia in 3D Temporal Images
by Tiffany T. Ly, Jie Wang, Kanchan Bisht, Ukpong Eyo and Scott T. Acton
Appl. Sci. 2021, 11(13), 6078; https://doi.org/10.3390/app11136078 - 30 Jun 2021
Viewed by 1584
Abstract
Automatic glia reconstruction is essential for the dynamic analysis of microglia motility and morphology, notably so in research on neurodegenerative diseases. In this paper, we propose an automatic 3D tracing algorithm called C3VFC that uses vector field convolution to find the critical points [...] Read more.
Automatic glia reconstruction is essential for the dynamic analysis of microglia motility and morphology, notably so in research on neurodegenerative diseases. In this paper, we propose an automatic 3D tracing algorithm called C3VFC that uses vector field convolution to find the critical points along the centerline of an object and trace paths that traverse back to the soma of every cell in an image. The solution provides detection and labeling of multiple cells in an image over time, leading to multi-object reconstruction. The reconstruction results can be used to extract bioinformatics from temporal data in different settings. The C3VFC reconstruction results found up to a 53% improvement on the next best performing state-of-the-art tracing method. C3VFC achieved the highest accuracy scores, in relation to the baseline results, in four of the five different measures: Entire structure average, the average bi-directional entire structure average, the different structure average, and the percentage of different structures. Full article
(This article belongs to the Special Issue Medical Image Analysis: From Small Size Data to Big Data)
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28 pages, 10199 KiB  
Article
A Comprehensive Review of Retinal Vascular and Optical Nerve Diseases Based on Optical Coherence Tomography Angiography
by Fatma Taher, Heba Kandil, Hatem Mahmoud, Ali Mahmoud, Ahmed Shalaby, Mohammed Ghazal, Marah Talal Alhalabi, Harpal Singh Sandhu and Ayman El-Baz
Appl. Sci. 2021, 11(9), 4158; https://doi.org/10.3390/app11094158 - 1 May 2021
Cited by 1 | Viewed by 2983
Abstract
The optical coherence tomography angiography (OCTA) is a noninvasive imaging technology which aims at imaging blood vessels in retina by studying decorrelation signals between multiple sequential OCT B-scans captured in the same cross section. Obtaining various vascular plexuses including deep and superficial choriocapillaris, [...] Read more.
The optical coherence tomography angiography (OCTA) is a noninvasive imaging technology which aims at imaging blood vessels in retina by studying decorrelation signals between multiple sequential OCT B-scans captured in the same cross section. Obtaining various vascular plexuses including deep and superficial choriocapillaris, is possible, which helps in understanding the ischemic processes that affect different retina layers. OCTA is a safe imaging modality that does not use dye. OCTA is also fast as it can capture high-resolution images in just seconds. Additionally, it is used in the assessment of structure and blood flow. OCTA provides anatomic details in addition to the vascular flow data. These details are important in understanding the tissue perfusion, specifically, in the absence of apparent morphological change. Using these anatomical details along with perfusion data, OCTA could be used in predicting several ophthalmic diseases. In this paper, we review the OCTA techniques and their ability to detect and diagnose several retinal vascular and optical nerve diseases, such as diabetic retinopathy (DR), anterior ischemic optic neuropathy (AION), age-related macular degeneration (AMD), glaucoma, retinal artery occlusion and retinal vein occlusion. Then, we discuss the main features and disadvantages of using OCTA as a retinal imaging method. Full article
(This article belongs to the Special Issue Medical Image Analysis: From Small Size Data to Big Data)
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14 pages, 2512 KiB  
Article
A Novel MRA-Based Framework for Segmenting the Cerebrovascular System and Correlating Cerebral Vascular Changes to Mean Arterial Pressure
by Fatma Taher, Heba Kandil, Yitzhak Gebru, Ali Mahmoud, Ahmed Shalaby, Shady El-Mashad and Ayman El-Baz
Appl. Sci. 2021, 11(9), 4022; https://doi.org/10.3390/app11094022 - 28 Apr 2021
Cited by 5 | Viewed by 1672
Abstract
Blood pressure (BP) changes with age are widespread, and systemic high blood pressure (HBP) is a serious factor in developing strokes and cognitive impairment. A non-invasive methodology to detect changes in human brain’s vasculature using Magnetic Resonance Angiography (MRA) data and correlation of [...] Read more.
Blood pressure (BP) changes with age are widespread, and systemic high blood pressure (HBP) is a serious factor in developing strokes and cognitive impairment. A non-invasive methodology to detect changes in human brain’s vasculature using Magnetic Resonance Angiography (MRA) data and correlation of cerebrovascular changes to mean arterial pressure (MAP) is presented. MRA data and systemic blood pressure measurements were gathered from patients (n = 15, M = 8, F = 7, Age = 49.2 ± 7.3 years) over 700 days (an initial visit and then a follow-up period of 2 years with a final visit.). A novel segmentation algorithm was developed to delineate brain blood vessels from surrounding tissue. Vascular probability distribution function (PDF) was calculated from segmentation data to correlate the temporal changes in cerebral vasculature to MAP calculated from systemic BP measurements. A 3D reconstruction of the cerebral vasculature was performed using a growing tree model. Segmentation results recorded 99.9% specificity and 99.7% sensitivity in identifying and delineating the brain’s vascular tree. The PDFs had a statistically significant correlation to MAP changes below the circle of Willis (p-value = 0.0007). This non-invasive methodology could be used to detect alterations in the cerebrovascular system by analyzing MRA images, which would assist clinicians in optimizing medical treatment plans of HBP. Full article
(This article belongs to the Special Issue Medical Image Analysis: From Small Size Data to Big Data)
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