Recent Advances in Medicinal and Synthetic Organic Chemistry

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: 31 March 2024 | Viewed by 888

Special Issue Editors

Department of Chemistry, University of Milan, 20133 Milan, Italy
Interests: synthetic organic chemistry; medicinal chemistry; carbohydrate chemistry
Special Issues, Collections and Topics in MDPI journals
Department of Medical Biotechnology and Translational Medicine, University of Milan, Via Saldini 50, 20133 Milan, Italy
Interests: synthetic organic chemistry; carbohydrate chemistry; glycoconjugates; biochemistry; glycolipid chemistry
Special Issues, Collections and Topics in MDPI journals
Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milan, Italy
Interests: medicinal chemistry; organic chemistry; chemical biology; new antibacterial small molecules; new antiviral small molecules

Special Issue Information

Dear Colleagues,

Medicinal chemistry is a constantly developing and evolving branch of life science research. It consists of the invention, discovery, design, identification and preparation of biologically active compounds. Synthetic organic chemistry, therefore, plays a key role in this type of research: the modification and manipulation of chemicals by increasingly emerging and innovative methods expand the possibility of synthesizing new compounds and molecules. The research for new methodologies, new classes of reactions, and new chemical entities represents attractive fields on which the efforts of thousands of researchers worldwide are focused. In recent years, discoveries in these fields have increased exponentially, making a significant contribution to the scientific community to overcome the continuing challenges that will need to be faced.

Therefore, the present Special Issue “Recent Advances in Medicinal and Synthetic Organic Chemistry” aims to collect significant and cutting-edge research works and bring out new ideas in the fields of Medicinal and Organic Chemistry, as short communications, full research papers, mini-reviews or full-length review paper. The Special Issue will consider recent works highlighting contributions on the following topics:

  • Organic synthesis and innovative methodologies;
  • Synthetic processes (including flow chemistry, microwave-assisted chemistry);
  • Homogeneous and heterogeneous catalysis;
  • Green chemistry;
  • Medicinal chemistry;
  • Agrochemicals and agro-drugs;
  • Bio-organic chemistry and chemical biology;
  • Natural products synthesis;
  • Studies of the reaction mechanism;
  • Synthetic materials and polymer chemistry.

Dr. Giuseppe D'Orazio
Dr. Laura Morelli
Dr. Sarah Mazzotta
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organic synthesis
  • innovative methodologies
  • process chemistry
  • catalysis
  • green chemistry
  • drugs
  • natural products
  • agrochemicals
  • medicinal chemistry
  • synthetic materials

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

21 pages, 3062 KiB  
Article
Structural, Conformational and Spectroscopic Investigations of a Biologically Active Compound: L-Dopa
Appl. Sci. 2023, 13(24), 13336; https://doi.org/10.3390/app132413336 - 18 Dec 2023
Viewed by 493
Abstract
Structural, conformational and spectroscopic investigations of the L-dopa molecule were made at the b3lyp/6-311++g** level using the Gaussian 09 software. IR, Raman and UV-vis spectra were measured and analyzed in light of the computed spectral quantities. Total energy vs. dihedral angle scans yielded [...] Read more.
Structural, conformational and spectroscopic investigations of the L-dopa molecule were made at the b3lyp/6-311++g** level using the Gaussian 09 software. IR, Raman and UV-vis spectra were measured and analyzed in light of the computed spectral quantities. Total energy vs. dihedral angle scans yielded 108 pairs of stable conformers of L-dopa. All the conformers had energies above 500 K relative to the lowest-energy conformer C-I. The observed spectra could be explained in terms of the computed spectra of the lowest-energy dimer of the C-I monomer. MEP and HOMO-LUMO analysis were carried out, and barrier heights and bioactivity scores were determined. The positive bioactive scores represent its higher medicinal and pharmaceutical applications. The present investigation suggests that the molecule has three active sites with moderate bioactivity. Full article
(This article belongs to the Special Issue Recent Advances in Medicinal and Synthetic Organic Chemistry)
Show Figures

Figure 1

Back to TopTop