Biodegradable Alloys, Polymers, and Composites for Implants

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 3644

Special Issue Editor


E-Mail Website
Guest Editor
Institute of Physical Chemistry “Ilie Murgulescu” of the Romanian Academy, Splaiul Independentei 202, 060021 Bucharest, Romania
Interests: materials characterization; green synthesis; nanomaterials; surface modification; microstructure; mechanical properties
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit your scientific manuscript to Applied Sciences for a Special Issue on “Biodegradable Alloys, Polymers, and Composites for Implants”.

Biodegradable implants are used in medicine for a wide range of applications, for example, poly(lactic-co-glycolic acid) (PLGA) is used for degradable sutures or as a drug delivery carrier; magnesium (Mg) alloys are used for degradable stents; and both biodegradable metals and polymers are used as fixation screws. The purpose of a degradable implant is to fulfill a biomedical function, such as a temporary support/barrier, for drug delivery, or a tissue-engineering scaffold which will degrade afterwards, without causing adverse side effects. Therefore, a second operation for removing the implant is not necessary. Biodegradable implants require the ability to vary the rate of degradation, a controlled rate of drug delivery, nontoxicity to the host tissue, the capability to withstand mechanical stress, and the ability to mimic a natural component of the body. Biodegradable composites can greatly benefit the combination of metal and polymer properties for use in bioimplants, e.g., magnesium polymer implants have excellent prospects for development, as they have demonstrated elastic properties similar to human cancellous bone and excellent cytocompatibility. The ever-growing demands for a better, healthy quality of life calls for the development of novel biodegradable medical implants. A complex, multidisciplinary challenge presents itself in which materials scientists and technologists, as well as healthcare specialists, must precisely design, manufacture, and functionalize personalized devices attaining the targeted physicochemical and biological properties for the desired shapes, sizes, and the living tissue and fluids of the surrounding host.

The aim of this Special Issue is to offer researchers involved in the development of advanced biodegradable medical materials a medium for presenting and disseminating original contributions in the field, especially novel approaches integrating added functionalities for biodegradable composite materials.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to):

  • Biodegradable metallic alloys, polymers and composites for biomedical applications, manufacture and fabrication; physicochemical properties; mechanical properties; corrosion behavior in body fluids; biological properties (biocompatibility, osseointegration, cytotoxicity, etc.).
  • Advances in composite materials for degradable medical devices with application in drug delivery; tissue-engineering scaffolds; temporary support; bone fixation, etc.

I look forward to receiving your contributions.

Dr. Jose Maria Calderon-Moreno
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical devices
  • drug delivery
  • tissue-engineering scaffolds
  • corrosion resistance
  • biocompatibility
  • surface modification
  • degradation mechanism
  • degradation rate
  • implant manufacturing
  • multifunctional implant

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

15 pages, 3713 KiB  
Article
Kinetics of PTSA-Catalysed Polycondensation of Citric Acid with 1,3-Propanediol
by Aleksandra Bandzerewicz, Mateusz Cegłowski, Klaudia Korytkowska and Agnieszka Gadomska-Gajadhur
Appl. Sci. 2022, 12(23), 12445; https://doi.org/10.3390/app122312445 - 05 Dec 2022
Cited by 1 | Viewed by 1352
Abstract
Recent years have seen the intensive development of novel therapies based on stem cells and advanced materials. Among the latter, polymers, especially polyesters, occupy a special place and are being investigated for use as substrates for cell differentiation and culture. Increasing application requirements [...] Read more.
Recent years have seen the intensive development of novel therapies based on stem cells and advanced materials. Among the latter, polymers, especially polyesters, occupy a special place and are being investigated for use as substrates for cell differentiation and culture. Increasing application requirements are driving demand for such materials. This study aims to obtain a new material with potential biomedical applications, poly(1,3-propanediol citrate). A spectral analysis of the obtained product was carried out. The reaction kinetics of the polycondensation of citric acid and 1,3-propanediol in the presence of a catalyst, p-toluenesulphonic acid (PTSA), are described. The basis for determining the polycondensation kinetics was the assumption of non-equivalence of the carboxyl groups in citric acid. Elementary reaction rate constants and activation energy values were determined. Based on the data obtained, the course of the gelation points of the reaction mixture was estimated in its dependence on the temperature and reaction time. Kinetic research will facilitate the scale-up of the process. Full article
(This article belongs to the Special Issue Biodegradable Alloys, Polymers, and Composites for Implants)
Show Figures

Figure 1

12 pages, 7299 KiB  
Communication
Synthesis of Hydroxyapatite (HAp)-Zirconia Nanocomposite Powder and Evaluation of Its Biocompatibility: An In Vitro Study
by Vignesh Raj Sivaperumal, Rajkumar Mani, Veerababu Polisetti, Kanakaraj Aruchamy and Taehwan Oh
Appl. Sci. 2022, 12(21), 11056; https://doi.org/10.3390/app122111056 - 01 Nov 2022
Cited by 5 | Viewed by 1934
Abstract
A potential material for dental restorations and bone replacements is calcium phosphate (CaP)-based ceramic material. Nevertheless, its limited ability to withstand thermal processing and weak mechanical strength prevents it from being used in hard tissue engineering. Hydroxyapatite has been extensively used as a [...] Read more.
A potential material for dental restorations and bone replacements is calcium phosphate (CaP)-based ceramic material. Nevertheless, its limited ability to withstand thermal processing and weak mechanical strength prevents it from being used in hard tissue engineering. Hydroxyapatite has been extensively used as a CaP-based biomaterial in prosthetic applications. On the other hand, zirconia is an inorganic material that combines outstanding mechanical capabilities with bioinert characteristics. In the present investigation, we demonstrated the reinforcement of zirconia in biomimetic hydroxyapatite (HAp) using a specially designed stir-type hydrothermal reactor to improve the biocompatibility and mechanical stability of bare hydroxyapatite. X-ray diffraction (XRD) analysis showed distinct peak shifts around 31° and 60°, which confirmed the formation of a nanocrystalline HAp-Zirconia composite without any intermediate phases. The size of the synthesized nanocomposite was found to be 30 nm using TEM. Further, the d-spacing value calculated from high-resolution transmission electron microscope (HRTEM) images corresponded to the distinct planes of the HAp (211) and zirconia (311) phases, respectively, in the composite powder. The in vitro cytotoxicity study revealed excellent biocompatibility with MG-63 human osteoblasts. Hence, the zirconia reinforced hydroxyapatite (HZ1) prepared in the present work could be utilized as a successful approach in a variety of hard tissue engineering applications. Full article
(This article belongs to the Special Issue Biodegradable Alloys, Polymers, and Composites for Implants)
Show Figures

Figure 1

Back to TopTop