Dear Colleagues,

In developed countries, cancer is the second main cause of death after cardiovascular diseases. However, cancer mortality has been decreasing in recent years. This is not only the result of an increase in cancer detection at an early stage, or the introduction of prevention, but also the result of new treatment options. Surgery, chemotherapy and radiotherapy are used in the treatment of cancer. The appropriate sequence of application of these methods, or the use of simultaneous radiotherapy and chemotherapy, allow for continuous improvement in treatment results. The introduction of new techniques in radiotherapy, such as IMRT, VMAT or stereotaxy, makes it possible to escalate doses to the tumor with simultaneous protection of healthy tissues and higher treatment tolerance. Moreover, supportive treatment during chemotherapy allows combining both methods. Examples of the use of radiochemotherapy before surgery and achieving improvement in results are found in the treatment of esophageal or rectal cancer. In some cases, thanks to the use of new techniques, radiotherapy is considered an equivalent method to surgery, e.g., in treating prostate cancer. Stereotactic radiotherapy can be used both in the case of radical treatment and metastatic lesions. One should also not forget about new molecular therapies, used both in the case of adjuvant treatment and generalized disease. The choice of management strategy is influenced not only by the disease stage, general condition, and past and present comorbidities but, above all, by the histological type and location of the neoplasm. Due to the multitude of treatment methods, the greatest difficulty seems to lie in planning the treatment. Therefore, raising the subject of a new approach in radiotherapy and chemotherapy as well as clinical applications appears justified.

For this issue, possible topics of interest may include:

1) Novel strategies for the treatment of cancer.

2) Combination cancer treatments—simultaneous and sequential radiochemotherapy as an independent radical treatment or in combination with surgical treatment.

3) Targeted treatment in combination with radiotherapy or chemotherapy.

4) Brachytherapy as a radical and palliative treatment.

Dr. Ludmiła Grzybowska-Szatkowska
Dr. Krzysztof Jeziorski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• radiotherapy
• sequential and simultaneous chemoradiotherapy
• brachytherapy
• targeted therapy