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Applied Sciences
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Advances and Applications of Biosensors, Biorobotics and Biomaterials at the...
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Advances and Applications of Biosensors, Biorobotics and Biomaterials at the Microscale

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 687

Special Issue Editors

Dr. Víctor de la Asunción-Nadal

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Guest Editor
Division of Applied Physical Chemistry, Department of Chemistry, KTH Royal Institute of Technology, Stockholm, Sweden
Interests: microrobotics; materials science; sensors; nanotechnology
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Beatriz Jurado Sánchez

E-Mail Website
Guest Editor
Departamento de Química Analítica, Química Física e Ingeniería Química, Universidad de Alcalá, Alcalá de Henares, Spain
Interests: micromotors; lab-on-a-chip; nanotechnology; sensors; environmental chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of microscale biological and bioinspired materials has garnered significant attention from both scientists and consumers alike due to the potential for employing miniaturized approaches in applications such as sensing, drug delivery, and single-cell targeting, among others. This opens up new avenues for previously unattainable applications. Furthermore, by integrating new smart materials, it becomes possible to equip these platforms with on-board (bio)recognition and transduction mechanisms. It is also crucial for the biomaterials community to comprehensively study and understand the principles of these operational mechanisms. This understanding will enable novel materials to function safely, efficiently, and with unparalleled precision, thereby expanding their range of applications.

In addition to developing new micromaterials, it is equally important to design peripheral equipment that can facilitate remote positioning, characterize their structure and operation, and generate physicochemical responses. Advancements in this area are pivotal for further enhancing the scope of applications.

This Special Issue will encompass recent breakthroughs in the development of new miniaturized biosensors, biorobots, and biomaterials, as well as novel applications that leverage their enhanced properties.

Dr. Víctor de la Asunción-Nadal
Prof. Dr. Beatriz Jurado Sánchez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • microbotics
  • biosensors
  • microscale actuation
  • micro/nanomaterials characterization
  • drug delivery
  • personalized medicine

Published Papers (1 paper)

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Research

25 pages, 4817 KiB  
Article
Modulation of the Cellular Microenvironment by Mechanical Fluid Shear Stress and Hypoxia Alters the Differentiation Capacity of Skeletal Muscle-Derived Stem Cells
by Paula Hawlitschek, Michele C. Klymiuk, Asmaa Eldaey, Sabine Wenisch, Stefan Arnhold and Mohamed I. Elashry
Appl. Sci. 2024, 14(7), 3047; https://doi.org/10.3390/app14073047 - 04 Apr 2024
Viewed by 412
Abstract
Skeletal muscle-derived stem cells (MDSCs) are the key modulators of muscle regeneration. An inappropriate cellular microenvironment can reduce the regenerative capacity of MDSCs. This study evaluates the effect of microenvironmental alterations on the cell differentiation capacity using either mechanical fluid shear stress (FSS) [...] Read more.
Skeletal muscle-derived stem cells (MDSCs) are the key modulators of muscle regeneration. An inappropriate cellular microenvironment can reduce the regenerative capacity of MDSCs. This study evaluates the effect of microenvironmental alterations on the cell differentiation capacity using either mechanical fluid shear stress (FSS) or hypoxic conditions. C2C12 mouse myoblasts were differentiated under cyclic FSS (CFSS), periodic FSS (PFSS) for one hour, and hypoxia (3% O2) for up to seven days. Cell proliferation and myogenic differentiation capacities were evaluated using cell viability assays, immunohistochemical staining, and morphometric analysis. The expression of MyoD, myogenin, myosin heavy chain, nitric oxide, hypoxia-inducible factor 1 alpha (HIF1α), vascular endothelial growth factor (VEGF) and mammalian target of rapamycin (mTOR) was quantified by means of RT-qPCR. The data showed that FSS conditions altered cell morphology and increased cell viability and cell distribution compared to static conditions. MyoD and myogenin expression was upregulated under both FSS conditions. CFSS induction improved myogenic differentiation parameters including myotube number, size and fusion capacity. Although hypoxia enhanced cell viability compared to normoxia, it reduced differentiation capacity, as indicated by the downregulation of myogenin and mTOR expression, as well as reducing myotube formation. Under hypoxic conditions, increased nitric oxide production and upregulation of VEGF expression were detected for up to 72 h. The data suggest an improved myogenic differentiation capacity under mechanical FSS; in contrast, the cell differentiation capacity was impaired under hypoxic conditions. The data point out that optimizing the biomechanical and oxidative stressors in the cellular microenvironment could improve stem cell transplantation and enhance their regenerative potential in the context of cell-based therapies. Full article
(This article belongs to the Special Issue Advances and Applications of Biosensors, Biorobotics and Biomaterials at the Microscale)
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