Role of Nrf2 in Neurodegenerative Diseases
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 10 December 2024 | Viewed by 114
Special Issue Editors
Interests: Alzheimer's disease; amyloidosis; neurodegenerative disorders; mitochondrial dysfunction; oxidative stress; cerebral amyloid angiopathy; neuroinflammation
Interests: Alzheimer disease; neurodegenerative disorders; systemic and cerebral amyloidoses; aging; proteomics; post-translational modifications; blood-brain-barrier; amyloid; neurofibrillary tangles; cerebral amyloid angiopathy; cerebral hemorrhage; translational approaches; mouse models
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent decades, the incidence of neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases, vascular dementia, and amyotrophic lateral sclerosis, among others, has remarkably increased worldwide. Despite extensive research, the complex molecular mechanisms driving the pathogenesis of these disorders have not been fully elucidated and disease-modifying therapeutic strategies remain to be discovered. Among the different pathways compromised in this diverse group of neurodegenerative diseases, mounting evidence highlights a central role of mitochondrial detrimental changes, oxidative stress, altered cerebral glucose metabolism, and metabolic/bioenergetic shifts that frequently precede cognitive abnormalities. The central element interlinking these complex pathways is Nrf2 (nuclear factor erythroid 2-related factor 2), a critical transcription factor that coordinates the expression of more than 500 cytoprotective and metabolic genes modulating inducible defence systems and regulating not only the antioxidant response but also mitochondria functioning as well as multiple points of the cell intermediary metabolism.
This Special Issue aims to provide insight into the role of Nrf2 in the interplay between the multifaceted molecular pathways linking metabolic/bioenergetic alterations, neuroinflammatory mechanisms, vascular dysfunction, and cognitive impairment associated with neurodegeneration. Manuscripts addressing the clinical implications and therapeutic potential of targeting the Nrf2 signaling pathway in neurodegenerative conditions are also of interest. We welcome contributions in the form of original research articles, reviews, and perspectives.
Dr. Agueda A. Rostagno
Prof. Dr. Jorge Ghiso
Guest Editors
Manuscript Submission Information
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Keywords
- Nrf2 pathway
- nuclear factor erythroid 2-related factor 2
- neuroprotection
- Parkinson’s disease
- Alzheimer’s disease
- neurodegenerative diseases
- neuroinflammation
- metabolic/bioenergetic alterations
- oxidative stress
- mitochondria
- amyotrophic lateral sclerosis
