Oxidative Stress-Induced by Environmental and Lifestyle Stressors: Impact on Reproductive Health and Development 3rd Edition

Dear Colleagues,

Our previous Special Issues on "Oxidative Stress Induced by Environmental and Lifestyle Stressors: Impact on Reproductive Health and Development” https://www.mdpi.com/journal/antioxidants/special_issues/Oxidative_Stress_Reproductive_Health and https://www.mdpi.com/journal/antioxidants/special_issues/Oxidative_Stress_Reproductive_Health_II received numerous submissions and were a successful compilation of research and review articles. A growing body of evidence supports the contribution of environmental and lifestyle stressors to the increased risk of developing non-communicable diseases, and large gaps in the knowledge surrounding the underlying biological mechanisms remain. Therefore, we wish to further explore the role of oxidative stress in reproductive and developmental health disorders related to exposure to environmental and lifestyle stressors.

Many environmental and lifestyle factors exert their toxic effects on reproductive health and development through impaired antioxidant defence and oxidative damage. Moreover, environmental exposure and the lifestyles of parents may play important roles in the future health status of any offspring, and oxidative stress and inflammation may be key mediators in this programming. The identification of risk factors and understanding the complex mechanisms underlying the various reproductive and developmental health disorders are fundamental research priorities. Comprehensive research using novel “omics” technologies and bioinformatics can provide a more holistic perspective and better understanding of the molecular mechanisms behind these adverse health effects. This Special Issue of Antioxidants titled “Oxidative Stress Induced by Environmental Stressors: Impact on the Reproductive Health and Development 3” focuses on the latest research related but not restricted to:

• The role of oxidative stress in the reproductive and developmental toxicity of metals/metalloids, pesticides, mycotoxins, phthalates, bisphenol A, parabens, flame retardants, nanoparticles and microplastics;
• The contribution of smoking, alcohol, drug of abuse, nutrition and obesity to oxidative stress and adverse health effects;
• The adverse effects of circadian rhythm disruption (chronodisruption) on reproductive health and development;
• The ameliorative/beneficial effects of antioxidants;
• The parameters of oxidative stress/antioxidant defence as potential novel biomarkers of reproductive and developmental health disorders;
• The proteomic and metabolomic signature of oxidative stress;
• The role of oxidative stress in the epigenetic modification of reproductive health and development;
• The impact of oxidative stress induced by early exposure to environmental and lifestyle factors on health disorders in later life.

Of interest are studies on low-level exposure and the effects of multiple toxicants/stressors and their interactions. Both observational (human biomonitoring) and experimental (in vivo and in vitro) studies are welcome. We invite authors in the field to submit their original articles, reviews, perspectives and short communications on this important topic.

Dr. Alica Pizent
Dr. Eva Tvrdá
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• foetal programming (developmental origins of health and disease)
• environmental exposure
• developmental and reproductive toxicology
• human biomonitoring
• fertility
• pregnancy
• offspring
• cancers of the reproductive system
• biomarker discovery
• “omics”
• epigenetics
• antioxidants