Relationship between Mitochondrial Nutrients and Antioxidant Activity

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Natural and Synthetic Antioxidants".

Deadline for manuscript submissions: closed (30 December 2022) | Viewed by 2796

Special Issue Editor

College of Food Science and Engineering, Northwest A&F University, Yangling District, Xianyang 712100, China
Interests: natural products and nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Mitochondria are the important energy center of cells and the source of free radicals. They have long been a topic of concern in the research of aging, neurodegenerative diseases, type 2 diabetes, cancer, and cardiovascular and cerebrovascular diseases. Mitochondrial nutrients refer to a group of nutrients that target mitochondria and can maintain and promote mitochondrial structure and function, including vitamins, polyphenols, trace elements, amino acids, active peptides, oligosaccharides, and other antioxidants. Mitochondrial nutrients can promote mitochondrial function, reduce the accumulation of oxidative products in mitochondria, repair mitochondrial membranes, induce antioxidant enzymes, and activate mitochondrial generation. Due to the central role of mitochondria in oxidative damage, mitochondrial degeneration is closely related to aging-related diseases. Mitochondrial nutrients can effectively alleviate mitochondrial oxidative damage and prevent and treat the occurrence and development of related diseases.

We invite you to submit your latest research findings or a review article to this Special Issue, which will bring together current research concerning the protective effect of natural biological active ingredients on mitochondria and its antioxidant mechanism and study the relationship between mitochondrial function and diseases related to oxidative stress. We are confident that this Special Issue of Antioxidants will contribute to the in-depth understanding of the relationship between mitochondria and the overall antioxidant capacity of cells, as well as the relationship between mitochondrial antioxidant systems and other antioxidant systems in cells, providing new ideas for the prevention and treatment of mitochondria-related diseases.

Dr. Qiang Peng
Guest Editor

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Keywords

  • mitochondrial nutrients
  • natural antioxidants
  • mitochondrial dysfunction
  • mitochondria-related diseases
  • antioxidative mechanism
  • mitochondrion structure
  • mitochondriopoiesis

Published Papers (1 paper)

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Research

15 pages, 2884 KiB  
Article
The Cytoprotective Effects of Baicalein on H2O2-Induced ROS by Maintaining Mitochondrial Homeostasis and Cellular Tight Junction in HaCaT Keratinocytes
by Gyeonghyeon Kim, Dong-Wook Han and Jong Hun Lee
Antioxidants 2023, 12(4), 902; https://doi.org/10.3390/antiox12040902 - 10 Apr 2023
Cited by 5 | Viewed by 2310
Abstract
Reactive oxygen species (ROS) promote oxidative stress, which directly causes molecular damage and disrupts cellular homeostasis, leading to skin aging. Baicalein, a flavonoid compound isolated from the root of Scutellaria baicalensis Georgi has antioxidant, anticancer, anti-inflammatory, and other medicinal properties. We aimed to [...] Read more.
Reactive oxygen species (ROS) promote oxidative stress, which directly causes molecular damage and disrupts cellular homeostasis, leading to skin aging. Baicalein, a flavonoid compound isolated from the root of Scutellaria baicalensis Georgi has antioxidant, anticancer, anti-inflammatory, and other medicinal properties. We aimed to investigate the protective effect of baicalein on the disruption of tight junctions and mitochondrial dysfunction caused by H2O2-induced oxidative stress in HaCaT keratinocytes. The cells were pretreated with 20 and 40 µM baicalein followed by treatment with 500 µM H2O2. The results revealed that baicalein exerted antioxidant effects by reducing intracellular ROS production. Baicalein attenuated the degradation of the ECM (MMP-1 and Col1A1) and the disruption of tight junctions (ZO-1, occludin, and claudin-4). In addition, baicalein prevented mitochondrial dysfunction (PGC-1α, PINK1, and Parkin) and restored mitochondrial respiration. Furthermore, baicalein regulated the expression of antioxidant enzymes, including NQO-1 and HO-1, via the Nrf2 signaling pathway. Our data suggest that the cytoprotective effects of baicalein against H2O2-induced oxidative stress may be mediated through the Nrf2/NQO-1/HO-1 signaling pathway. In conclusion, baicalein exerts potent antioxidant effects against H2O2-induced oxidative stress in HaCaT keratinocytes by maintaining mitochondrial homeostasis and cellular tight junctions. Full article
(This article belongs to the Special Issue Relationship between Mitochondrial Nutrients and Antioxidant Activity)
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