Understanding Oxidative Stress in Cardiovascular Disorders

Dear Colleagues,

We are pleased to introduce our forthcoming Special Issue, which will delve into the critical relationship between oxidative stress and cardiovascular diseases (CVDs). Oxidative stress, characterized by an imbalance between reactive oxygen species (ROS) production and the body's antioxidant defenses, has emerged as a central player in the pathogenesis and progression of various cardiovascular disorders.

This Special Issue aims to illuminate the intricate mechanisms through which oxidative stress contributes to the development and exacerbation of CVDs, including atherosclerosis, hypertension, myocardial infarction, and heart failure. By unraveling the involved molecular pathways, we seek to identify novel therapeutic targets and interventions to combat these debilitating conditions.

Contributions to this Special Issue will explore the multifaceted roles of oxidative stress in CVDs, from its impact on endothelial dysfunction and vascular inflammation to its involvement in myocardial remodeling and cardiac dysfunction. Researchers are encouraged to investigate both the upstream triggers of oxidative stress, such as dyslipidemia, hypertension, and diabetes, as well as the downstream consequences, including the oxidative modification of lipids, proteins, and DNA.

Furthermore, we welcome studies that explore the potential of antioxidant therapies and lifestyle interventions in mitigating oxidative stress and preventing CVDs. From preclinical research elucidating the efficacy of novel antioxidants to clinical trials evaluating the cardiovascular benefits of dietary modifications and exercise interventions, this Special Issue aims to provide a comprehensive overview of current strategies for managing oxidative stress in the context of cardiovascular health.

In summary, this Special Issue seeks to advance our understanding of the complex interplay between oxidative stress and cardiovascular diseases. By identifying key molecular targets and therapeutic strategies, we aim to pave the way for innovative approaches to prevent, diagnose, and treat CVDs, ultimately improving patient outcomes and reducing the global burden of cardiovascular morbidity and mortality.

Dr. Matteo Becatti
Dr. Claudia Fiorillo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• oxidative stress
• reactive oxygen species
• cardiovascular diseases
• antioxidants
• diet
• exercise