Paraoxonase Modulation by Dietary Factors: Implications for Health and Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Antioxidant Enzyme Systems".
Deadline for manuscript submissions: 20 June 2024 | Viewed by 155
Special Issue Editors
Interests: plant bioactive compounds; functional food and beverages; oxidative stress; antioxidants; lifestyle-related diseases
Special Issues, Collections and Topics in MDPI journals
Interests: lipid peroxidation; lipoprotein; biological membrane; antioxidants; reactive oxygen species; paraoxonase
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Human paraoxonase (PON) is a member of the gene family that includes paraoxonase 1 (PON1), PON2 and PON3. PON1 and PON3 are both associated with high-density lipoprotein (HDL) particles and exert antioxidant and anti-inflammatory properties. PON2 and PON3 are intracellular enzymes that modulate mitochondrial superoxide anion production and endoplasmic reticulum (ER)-stress-induced apoptosis. The pleiotropic roles exerted by PONs have been investigated in pathological conditions such as cardiovascular diseases, neurodegenerative diseases, inflammatory diseases, renal failure, and gastrointestinal disorders. PONs also provide microbial protection by hydrolyzing bacterial quorum lactone. There is increasing evidence that PONs may be involved in molecular mechanisms of cancer development and progression since alterations of PON expression and activity have been demonstrated in different human tumors. Due to the properties of PONs, it is of potential interest to identify environmental modulators of the activity and concentration of PONs. Dietary factors may represent one of the environmental factors potentially involved, and this Special Issue focuses on dietary factors that may affect the activity and concentration of PONs in humans.
We invite you to submit your latest research findings or a review article to this Special Issue, which will bring together current research concerning paraoxonases and the role that dietary factors can play in the modulation of PONs in both normal processes as well as diseased states.
We look forward to your contribution.
Dr. Tiziana Bacchetti
Dr. Gianna Ferretti
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- paraoxonases
- dietary factors
- oxidative stress
- nutrigenomic
- antioxidant enzymes
