Oxidative Stress and Lysosomal Function in Health and Disease
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 25 September 2024 | Viewed by 65
Special Issue Editors
Interests: lysosomal dysfunction; lysosomal storage disorders; cholesterol; lipids; lipid intracellular transport; cholesterol neurodegenerative diseases; liver diseases
Interests: lysosomal dysfunction; neurobiology; synaptic plasticity; neurodegenerative diseases
Special Issue Information
Dear Colleagues,
Lysosomes are the cellular center for degradation and recycling of a variety of biological macromolecules. Moreover, they are essential for autophagy and fulfill relevant functions as a metabolic signaling platform that intersects with multiple pathways. In addition, lysosomes dynamically and strongly communicate with other key organelles involved in cellular metabolism, such as the endoplasmic reticulum and mitochondria.
Therefore, lysosome functionality has significant implications for health and disease. In this context, alterations in lysosome homeostasis are associated with diverse disorders which include common diseases, such as obesity, liver steatosis, Alzheimer's, and Parkinson's, and less frequent ones, such as lysosomal storage diseases. Interestingly, mounting evidence shows that increased oxidative stress induces lysosome damage, potentially compromising its functionality and therefore several processes in which this organelle participates, including autophagy.
We invite you to submit to this Special Issue that will bring together current research relating oxidative stress to lysosome function in health and disease, including both in vitro and in vivo studies. Your latest research findings or review articles are also welcome.
We look forward to your contributions.
Dr. Silvana M. Zanlungo
Dr. Alejandra R. Álvarez
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lysosome
- lysosomal dysfunction
- lysosome homeostasis
- autophagy
- oxidative stress
