Reactive Oxygen Species as a Link between Metabolic and Cardiovascular Disease

Dear Colleagues,

Cardiovascular and metabolic disease comprise overlapping entities with shared underlying pathogenic mechanisms. Redox signalling is a key component of multiple cardiovascular processes, including endothelial function, inflammation, myocardial energetics and arrhythmogenesis. Importantly, oxidative stress may be propagated by metabolic stimuli such as nutrient overload and hormonal signalling via insulin and other adipocytokines secreted by dysfunctional adipose tissue in the context of obesity. This suggests a potential mechanistic link of cardiovascular disease with metabolic entities such as obesity, insulin resistance and diabetes, via reactive oxygen species regulation. Recent evidence suggests that metabolically active interventions, such as antidiabetic or anti-obesity medications, may have direct pleiotropic effects on cardiovascular redox state. Such effects may be clinically important as a means of indirect cardiovascular redox regulation, considering that direct pharmacological targeting of cardiovascular reactive oxygen species remains challenging from a therapeutic perspective. Individualised precision medicine approaches dictate an ongoing need for comprehensive characterisation of the interplay between metabolic and cardiovascular disease, and novel -omics methodologies (such as metabolomic and transcriptomic phenotyping of the cardiovascular system and adipose tissue) are currently providing novel insights into the determinants and consequences of reactive oxygen species in this context.

This Special Issue aims at comprehensively revisiting the role of reactive oxygen species in a range of cardiovascular disease phenotypes, such as atherosclerosis and atrial fibrillation, whilst evaluating the contribution of metabolic disease stimuli in regulating the cardiovascular redox state.

Dr. Ioannis Akoumianakis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• reactive oxygen species
• oxidative stress
• cardiovascular disease
• endothelial dysfunction
• atherosclerosis
• atrial fibrillation
• diabetes
• insulin resistance
• obesity
• adipose tissue biology