Exploring Endoplasmic Reticulum Stress in Disease: The Therapeutic Potential of Natural Pro- and Antioxidant Compounds in Redox Modulation
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 82
Special Issue Editors
Interests: agro-industrial by-products; bioactive compounds; antioxidants; foods; green extraction
Interests: protein misfolding disorders; ER stress; antioxidants; biochemistry of cancer
Special Issues, Collections and Topics in MDPI journals
Interests: chromatography; mass spectrometry; hyphenated analytical techniques; peptidomics; natural compounds; pharmacokinetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The endoplasmic reticulum (ER) is responsible for folding and modifying proteins before transporting them within the cell. Pathological conditions like nutrient deprivation, oxidative stress, and changes in calcium levels can lead to ER stress due to an imbalance between protein-folding capacity and the demand for properly folded proteins. ER stress is implicated in various diseases, including neurodegenerative diseases, metabolic disorders (e.g., obesity, type 2 diabetes), cardiovascular diseases (e.g., atherosclerosis, heart failure, ischemia–reperfusion injury), inflammatory dis-orders (e.g., inflammatory bowel disease, rheumatoid arthritis, asthma), and cancer.
Understanding the role of ER stress in disease pathogenesis may drive novel therapeutic strategies targeting the ER stress response. Natural products are gaining attention for their potential to either mitigate or trigger oxidative and ER stress, yet further research is needed to fully understand their biochemical mechanisms in ER stress modulation to develop effective treatments.
We invite researchers to submit their original research and review articles aimed at deepening the understanding of and providing new perspectives on the effectiveness of plant-derived compounds, nutraceuticals, and functional foods in modulating ER stress for the treatment of associated diseases. Additionally, we welcome innovative methods for isolating and characterizing bioactive natural compounds and their mechanisms, uncovering new biological targets associated with ER stress, and elucidating their pharmacological effects.
Dr. Giacomo Pepe
Dr. Vincenzo Vestuto
Dr. Manuela Giovanna Basilicata
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- bioactive compounds
- endoplasmic reticulum stress
- inflammation
- natural products
- nutraceuticals
- oxidative stress
- protein misfolding
- ROS
- omics sciences
