Reactive Oxygen Species in Photodynamic Therapy (PDT) and Radiation Therapy (RT)
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "ROS, RNS and RSS".
Deadline for manuscript submissions: 20 October 2024 | Viewed by 48
Special Issue Editors
Interests: reactive oxygen species explicit dosimetry; singlet oxygen explicit dosimetry; photodynamic therapy; radiation therapy
Special Issue Information
Dear Colleagues,
Reactive oxygen species (ROS) play a key role in photodynamic therapy and radiation therapy, especially given the increased interest in FLASH-RT in the latter field. The continuously increasing capability that can be achieved by new generations of dosimetrical tools is making it feasible to quantify ROS more directly, via various means. This evolution has set the stage for us to understand the role of ROS in PDT and RT. For example, the explicit dosimetry of light, photosensitizers, oxygen concentration, and radiation dosage has made it possible to model the interactions and generation of ROS in PDT and RT. Direct methods are being developed to measure components of ROS, e.g., singlet oxygen (SO) detection using singlet oxygen luminescence. In FLASH-RT, there is an awareness of the potential importance of ROS in demonstrating the difference between killing a tumor and damaging normal tissue. Given the plurality of imaging techniques available for initial staging, each clinical challenge can be met with a tailored image guidance solution.
This Special Issue aims to provide an up-to-date overview of the most recent (technical) advances in the field of ROS modeling and detection. For a variety of cancers and interventions, we will cover the in vivo and in vitro uses of innovative technique to detect ROS for a wide range of modalities. Translational efforts and works that demonstrate the benefits for patients are of particular interest.
Prof. Dr. Timothy C. Zhu
Prof. Dr. Brian C. Wilson
Guest Editors
Manuscript Submission Information
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Keywords
- reactive oxygen species (ROS)
- singlet oxygen (SO)
- radiation
- photodynamic therapy
- cancers
