Natural Antioxidants: Characterization, Synthetic Analogues and Potential Applications—2nd Edition

Dear Colleagues,

Our previous Special Issue on "Natural Antioxidants: Characterization, Synthetic Analogues and Potential Applications" compiled 14 publications covering all aspects of isolation, characterization, preclinical and clinical evaluation of natural and synthetic antioxidants. In the 2nd edition of this Special Issue, we invite more interested scientists to share their findings and views on the topic.

The formation of free radicals is the result of the advantageous oxidative metabolism, and they mediate important biological processes. However, a redox imbalance (oxidative stress) caused by the interplay of many intrinsic and extrinsic factors participates in the pathogenesis and development of many degenerative diseases and their complications. In order to alleviate the oxidative consequences in the human organism, scientists have turned to the pursuit of antioxidants of natural or synthetic origin, i.e., compounds that have reducing or radical-scavenging properties. Natural antioxidants are not limited to vitamins C and E but encompass numerous polyphenols, carotenoids and other natural product classes. Furthermore, synthetic analogues are developed, and both are used as pharmaceutical, food or cosmetic ingredients/additives. However, the term "natural" or "antioxidant" does not preclude other biological or even mutagenic, teratogenic and carcinogenic effects, and thus, experiments should be conducted using realistic low concentrations relevant to their final use, and their safety, bioavailability and bioaccessibility need to be assessed.

In this Special Issue, we welcome contributions on the isolation of natural products and extracts from natural sources including agricultural/food byproducts or waste; the characterization of their chemical composition; the design, synthesis and structural elucidation of natural product analogues with modern chromatographic and spectroscopic techniques; the in vitro and in vivo documentation of their antioxidant properties; and their potential applications, especially in the pharmaceutical, cosmetic and food industries. Manuscripts assuming a holistic multidisciplinary approach are most welcome, whereas manuscripts that only present the results of colorimetric antioxidant and phenolic determination assays—such as the Folin–Ciocalteau, FRAP and DPPH assays—without any characterization of plant extracts/essential oils with LC-DAD, LC-MS, GC-FID or GC-MS techniques will not be accepted.

Prof. Dr. Fotini Lamari
Dr. Manolis Fousteris
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• antioxidants
• plants
• agricultural byproducts
• carotenoids
• algae
• marine organisms
• microorganisms
• polyphenols
• tocopherols
• natural products
• synthetic derivatives

• Natural Antioxidants: Characterization, Synthetic Analogues and Potential Applications in Antioxidants (14 articles)