Modulation of Oxidative Stress and Inflammation in the Cardio-Renal Axis
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 157
Special Issue Editor
Interests: chronic kidney disease (CKD); acute kidney injury (AKI); glomerular damage; renal inflammation; renal fibrosis; tubular damage
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic kidney disease (CKD) is considered a risk factor for cardiovascular disease (CVD). The presence of both conditions in patients, named cardio-renal syndrome (CRS), increases the mortality risk dramatically. In response to injury, an inflammatory response occurs to maintain tissue integrity and homeostasis. However, in pathological conditions, such as CRS, there is a sustained activation of the inflammatory response, amplifying the end-organ damage. Another important mechanism in CRS is the deregulation of redox processes. Reactive oxygen species (ROS) can act as intracellular signaling mediators involved in the regulation of essential cellular functions, both in physiological and pathological conditions. Preclinical studies have described beneficial effects of targeting inflammation or oxidative stress in CKD and CVD, suggesting that maintaining the redox balance and modulating inflammatory mediators is a promising therapeutic strategy for CRS.
We invite you to submit your latest research studies or a review article concerning the signaling pathways implicated in the modulation of inflammatory and redox processes that contribute to the development and progression of the main vascular pathologies that could be affected by kidney injury or vice versa (renal pathologies affecting cardiovascular system), as well as novel therapeutic strategies that could be applied in CRS. We believe that this Special Issue, “Modulation of oxidative stress and inflammation in the cardio-renal axis”, will help to highlight the most recent advances in all aspects of meta-inflammation in the cardio-renal axis.
Dr. Sandra Rayego-Mateos
Guest Editor
Manuscript Submission Information
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Keywords
- cardio-renal syndrome
- chronic kidney disease
- cardiovascular disease
- renal inflammation
- reactive oxygen species
- oxidative stress
