Antioxidant Role of High-Density Lipoprotein
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: 31 October 2024 | Viewed by 71
Special Issue Editor
Special Issue Information
Dear Colleagues,
In the last 25 years, evidence has accumulated that LDL, which has undergone oxidation or glucoxidation, is cytotoxic to endothelial cells, and once it has crossed the arterial endothelium, it can be rapidly taken up by monocyte macrophages and smooth muscle cells in the arterial subintima to form foam cells responsible for the initiation and propagation of atherosclerosis. During the same period, our views about HDL have undergone radical revision: evidence that its anti-atherogenic role is because it is critical for reverse cholesterol transport has proved insubstantial. Most excess cholesterol secreted by the liver is removed before cellular uptake by a process in which HDL is not rate-limiting. Attention continues to be directed towards HDL as an early acceptor of excess intracellular cholesterol, but at the same time, it has been widely reported that HDL can protect LDL and cell membranes against oxidative modification, which can contribute to numerous disease processes besides atheroma. HDL is the repository of numerous proteins and lipids that can potentially protect both tissues and lipoproteins, but particularly in inflammation, HDL can undergo compositional change, rendering it proinflammatory and proatherogenic. This series of reviews and articles highlights the mechanisms and components contributing to the antioxidant role of HDL and the disease associations of HDL in which this characteristic is diminished.
Prof. Dr. Paul Durrington
Guest Editor
Manuscript Submission Information
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Keywords
- lipoprotein oxidation
- cell membrane oxidation
- HDL antioxidant activity
- glycosylation
- atherosclerosis
