The Reactive Species Interactome in Redox Regulation Processes

Dear Colleagues,

The intricate web of interactions between reactive species, collectively known as the reactive species interactome (RSI), plays a fundamental role in the redox regulation of biological processes. Reactive species, including reactive oxygen species (ROS), reactive sulphur species (RSS), and reactive nitrogen species (RNS), are no longer viewed solely as damaging agents but rather as crucial signalling molecules that participate in diverse cellular pathways. This Special Issue in Antioxidants aims to explore the peculiar properties and significance of the RSI and shed light on the importance of the reactive species interactome in governing redox regulation and its impact on various biological processes.

"Exploring the Reactive Species Interactome: An Overview"

A section of this issue will be devoted to describing the rich and multifaceted biological chemistry of the RSI, highlighting the interplay between different reactive species and their diverse targets within cells, from proteins to organelles. Specific attention will be paid to systemic approaches that describe how this peculiar chemistry connects biomolecules and biological structures within one single and evolving redox landscape.

Based on this knowledge, we wish to analyse the way this chemistry challenges the concepts at the core of redox biology such as oxidative stress, homeostasis, and redox equilibrium, and how it questions the language we use and the representation of biological regulation.

"Redox Regulation of Cellular Signalling and Metabolism through the Reactive Species Interactome"

This section will address the way the RSI is synchronized and integrated in complex regulation systems. We will welcome non-reductionist approaches that describe and analyse the articulation between different signal/redox networks, and their integration within physiological adaptive responses. In addition, systems biochemistry that underlines the organisation, redundancies, nodes, and vulnerabilities of the RSI networks will be covered.

This approach could depict various subtypes of RSI in organelles and/or for specific biological processes. As an example, this section will explore the role of the reactive species interactome in regulating mitochondrial function and cellular metabolism. Authors could also address the way the reactive species interactome connects various cellular compartments (including mitochondria), providing a communication system that helps to maintain metabolic homeostasis.

"The Reactive Species Interactome and Redox-Related Diseases"

This section will focus on the role of the reactive species interactome in the pathogenesis of redox-related diseases. It aims to elucidate how perturbations in the redox landscape and networks can lead to the dysregulation of redox homeostasis and chronic oxidative stress, contributing to the development and progression of various disorders, including cardiovascular diseases, neurodegenerative diseases, and cancer. The authors will highlight the importance of redox dysbiosis and the necessity to assess and restore the reactive species interactome to implement potential therapeutic strategies.

"Emerging Techniques to Study the Reactive Species Interactome"

This section will review the emerging techniques and tools used to study the reactive species interactome. It will highlight the advancements in redox proteomics, metabolomics, and imaging approaches that enable the identification and quantification of redox-sensitive molecules and their interactions within cellular systems. We will pay special attention to the development and evaluation of new methods to monitor the complexity, properties, and evolution of the RSI in complex and rich biological milieu. In particular, we will favour integrative approaches that characterize the milieu as a complex and evolving redox system. Authors are invited to discuss the future prospects and challenges in deciphering the complex dynamics of the reactive species interactome.

Conclusion: This Special Issue in Antioxidants underscores the pivotal role of the reactive species interactome in the redox regulation of biological processes. By elucidating the complex interactions between reactive species and cellular components, we hope to gain a deeper understanding of how redox signalling influences cellular homeostasis, signalling pathways, disease development, and metabolic processes. The articles presented in this issue will emphasize the biological significance of the reactive species interactome and pave the way for future research endeavours aimed at harnessing its potential for therapeutic interventions and disease prevention.

Dr. Jérôme Santolini
Guest Editor

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• redox homeostasis
• reactive nitrogen/oxygen/sulfur species
• mitochondria
• redox signalling
• metabolism
• systems biology
• neurodegenerative disorders
• redox analytical chemistry
• chronic disease
• inflammation