Special Issue "Feature Review Papers on β-Lactam and β-Lactam-β-Lactamase Inhibitor Combinations and Resistance Mechanisms to β-Lactam and β-Lactam-β-Lactamase Inhibitor Combinations"

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Mechanism and Evolution of Antibiotic Resistance".

Deadline for manuscript submissions: 31 October 2023 | Viewed by 323

Special Issue Editors

Operations Manager, JMI Laboratories, A Subsidiary of Element Materials Technology, 345 Beaver Kreek Center, Suite A, North Liberty, IA 52317, USA
Interests: Serine β-lactamases, β-lactams; β-lactamase inhibitors; Burkholderia; carbapenem-resistant Gram negatives; structure-activity relationships; enzyme kinetics; mass spectrometry
Special Issues, Collections and Topics in MDPI journals
Department of Microbiology and Molecular Biology, CWRU-Cleveland VAMC Center for Antimicrobial Resistance and Epidemiology, Case Western Reserve University, Cleveland, OH, USA
Interests: metallo-β-lactamases; β-lactams; β-lactamase inhibitors; stenotrophomonas; structure-activity relationships; enzyme kinetics; mass spectrometry
Dr. Clyde Smith
E-Mail Website
Guest Editor
Department of Chemistry, and the Stanford Synchrotron Radiation Lightsource (SSRL), Stanford University, Stanford, CA, USA
Interests: structural studies on mechanisms of resistance to β-lactam antibiotics and inhibitors; serine β-lactamases
Dr. Philip Hinchliffe
E-Mail Website
Guest Editor
School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK
Interests: structural studies on mechanisms of resistance to β-lactam antibiotics and inhibitors; serine and metallo-β-lactamases
Louis Stokes Cleveland VA Medical Center and Case Western Reserve University, Cleveland, OH, USA
Interests: mycobacterial infections; β-lactams; Gram negatives; Enterococci; dual β-lactams and β-lactamase inhibitors

Special Issue Information

Dear Colleagues,

The description of the topic:   β-Lactam and β-lactamase inhibitors are the safest and most commonly prescribed class of antibiotics. Over the last decade, great progress has been made in combating the emergence of β-lactam resistance in Gram-negative pathogens. Moreover, highly β-lactam-resistant pathogens continue to emerge in the clinic, challenging our current diagnostics as well as treatment strategies. The goal of this Special Issue is to gather the world’s leading experts in the field and provide the readership with a collection of focused review articles regarding these topics. Review articles regarding β-lactam agents, resistance mechanisms that lead to β-lactam resistance, as well as reviews concerning clinical challenges and diagnostic tools are welcomed.

Dr. Krisztina M. Papp-Wallace
Dr. Maria Fernanda Mojica
Dr. Clyde Smith
Dr. Philip Hinchliffe
Dr. Khalid Dousa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • β-lactamase
  • β-lactam
  • β-lactamase inhibitor
  • Gram-negatives
  • resistance mechanisms
  • clinical challenges
  • penicillin binding proteins
  • porins
  • outer membrane vesicles
  • diagnostics
  • antibiotic stewardship

Published Papers

This special issue is now open for submission.
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