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Antibiotics
Special Issues
Wildlife Sentinels of Antimicrobial Resistance
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Wildlife Sentinels of Antimicrobial Resistance

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiotics in Animal Health".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 5069

Special Issue Editor

Dr. Miguel Grilo

E-Mail Website
Guest Editor
1. Egas Moniz - Cooperativa de Ensino Superior, Crl, Quinta da Granja, Monte da Caparica, Portugal
2. MARE—Marine and Environmental Sciences Centre, ISPA—Instituto Universitário de Ciências Psicológicas, Sociais e da Vida, Lisboa, Portugal
Interests: conservation medicine; bacteriology; antimicrobial resistance

Special Issue Information

Dear Colleagues,

Wild animal populations are widely acknowledged as reservoirs of antimicrobial resistance (AMR) in natural environments. Although prevalence rates and resistance determinants’ diversity are modulated by ecological constraints often particular for specific populations and geographical areas, the consolidation of the reservoir status of wild species and their contribution to the dissemination of resistance determinants renders wildlife an important key role in the AMR cycle.

Surveillance is a crucial task in the integrated action plan to tackle AMR and decrease the economical and health burdens associated with this phenomenon. Dedicated and systematic surveillance focusing on the detection of resistance determinants in wild animal species have the potential to disclose anthropogenic pressures on natural habitats, track natural AMR events that can have an impact on Human and Veterinary Medicine, and estimate the risk of resistance determinants circulation from the environment to anthropogenic settings. Furthermore, studies focusing on the impact of resistance determinants on wild species homeostasis, through processes of host-microbiota disturbance, are needed in the framework of ongoing conservation efforts of vulnerable species.

This Special Issue aims to publish original manuscripts focusing on different aspects of the concept of wildlife as reservoirs of AMR, including surveillance programs, epidemiology, detection of novel resistance mechanisms, risk analysis, and impacts on the host.

Dr. Miguel Grilo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • wildlife
  • reservoir
  • antimicrobial resistance
  • surveillance
  • epidemiology
  • risk analysis
  • impact on host

Published Papers (3 papers)

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10 pages, 2323 KiB  
Article
Occurrence of ESBL- and AmpC-Producing E. coli in French Griffon Vultures Feeding on Extensive Livestock Carcasses
by Marisa Haenni, Laetitia Du Fraysseix, Pauline François, Antoine Drapeau, Tristan Bralet, Jean-Yves Madec, Thierry Boulinier and Olivier Duriez
Antibiotics 2023, 12(7), 1160; https://doi.org/10.3390/antibiotics12071160 - 7 Jul 2023
Viewed by 1161
Abstract
Despite the fact that the selective pressure of antibiotics on wild birds is supposed to be very weak, they are considered potential vectors of antimicrobial resistance (AMR). Obligate scavengers such as vultures can present high proportions of resistance to extended-spectrum cephalosporins (ESC) and [...] Read more.
Despite the fact that the selective pressure of antibiotics on wild birds is supposed to be very weak, they are considered potential vectors of antimicrobial resistance (AMR). Obligate scavengers such as vultures can present high proportions of resistance to extended-spectrum cephalosporins (ESC) and multi-drug-resistant (MDR) bacteria, partially due to feeding stations that are provisioned with livestock carcasses from intensive farming. Here we investigated whether griffon vultures (Gyps fulvus) from two populations located in the French Alps, which feed on livestock carcasses from extensive farms, may carry such resistant bacteria. Phenotypic and genotypic characterization showed an 11.8% proportion of ESC-resistant bacteria, including five extended-spectrum beta-lactamase (ESBL)-producing and one AmpC-producing E. coli. The five ESBL-positive E. coli were clonal and all came from the same vulture population, proving their spread between animals. The ESBL phenotype was due to a blaCTX-M-15 gene located on the chromosome. Both ESBL- and AmpC-positive E. coli belonged to minor STs (ST212 and ST3274, respectively); interestingly, ST212 has already been identified in wild birds around the world, including vultures. These results suggest that actions are needed to mitigate the spread of MDR bacteria through wild birds, particularly in commensal species. Full article
(This article belongs to the Special Issue Wildlife Sentinels of Antimicrobial Resistance)
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15 pages, 1596 KiB  
Article
Domestic Waste and Wastewaters as Potential Sources of Pharmaceuticals in Nestling White Storks (Ciconia ciconia)
by Guillermo Blanco, Pilar Gómez-Ramírez, Silvia Espín, Pablo Sánchez-Virosta, Óscar Frías and Antonio J. García-Fernández
Antibiotics 2023, 12(3), 520; https://doi.org/10.3390/antibiotics12030520 - 5 Mar 2023
Cited by 4 | Viewed by 2211
Abstract
Information on the exposure of wild birds to pharmaceuticals from wastewater and urban refuse is scarce despite the enormous amount of drugs consumed and discarded by human populations. We tested for the presence of a battery of antibiotics, NSAIDs, and analgesics in the [...] Read more.
Information on the exposure of wild birds to pharmaceuticals from wastewater and urban refuse is scarce despite the enormous amount of drugs consumed and discarded by human populations. We tested for the presence of a battery of antibiotics, NSAIDs, and analgesics in the blood of white stork (Ciconia ciconia) nestlings in the vicinity of urban waste dumps and contaminated rivers in Madrid, central Spain. We also carried out a literature review on the occurrence and concentration of the tested compounds in other wild bird species to further evaluate possible shared exposure routes with white storks. The presence of two pharmaceutical drugs (the analgesic acetaminophen and the antibiotic marbofloxacin) out of fourteen analysed in the blood of nestlings was confirmed in 15% of individuals (n = 20) and in 30% of the nests (n = 10). The apparently low occurrence and concentration (acetaminophen: 9.45 ng mL−1; marbofloxacin: 7.21 ng mL−1) in nestlings from different nests suggests the uptake through food acquired in rubbish dumps rather than through contaminated flowing water provided by parents to offspring. As with other synthetic materials, different administration forms (tablets, capsules, and gels) of acetaminophen discarded in household waste could be accidentally ingested when parent storks forage on rubbish to provide meat scraps to their nestlings. The presence of the fluoroquinolone marbofloxacin, exclusively used in veterinary medicine, suggests exposure via consumption of meat residues of treated animals for human consumption found in rubbish dumps, as documented previously at higher concentrations in vultures consuming entire carcasses of large livestock. Control measures and ecopharmacovigilance frameworks are needed to minimize the release of pharmaceutical compounds from the human population into the environment. Full article
(This article belongs to the Special Issue Wildlife Sentinels of Antimicrobial Resistance)
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10 pages, 721 KiB  
Brief Report
Antibiotic Resistance in the Apennine Wolf (Canis lupus italicus): Implications for Wildlife and Human Health
by Camilla Smoglica, Simone Angelucci, Fabrizia Di Tana, Antonio Antonucci, Fulvio Marsilio and Cristina Esmeralda Di Francesco
Antibiotics 2023, 12(6), 950; https://doi.org/10.3390/antibiotics12060950 - 23 May 2023
Cited by 4 | Viewed by 1281
Abstract
The Apennine wolf (Canis lupus italicus) is a subspecies of gray wolf that is widespread throughout Italy. Due to hunting and habitat loss, their population declined dramatically in the late 19th and early 20th centuries, but conservation efforts improved to restore [...] Read more.
The Apennine wolf (Canis lupus italicus) is a subspecies of gray wolf that is widespread throughout Italy. Due to hunting and habitat loss, their population declined dramatically in the late 19th and early 20th centuries, but conservation efforts improved to restore the species to an estimated population of 3300 individuals. The presence of antibiotic-resistant bacteria in Apennine Wolf may pose a risk to its health and survival, as well as the health of other animals in its environment. In this study, we investigated the antibiotic resistance profiles of bacteria collected from Apennine wolves admitted to the Wildlife Research Center of Maiella National Park (Italy) in 2022. A total of 12 bacteria collected from four wolves were isolated and tested for susceptibility to antibiotics used in veterinary medicine and to critically important antibiotics for human health by means of the Vitek 2 system. All isolates were resistant to at least one antibiotic, and six bacteria were multidrug resistant to critically important antibiotics (third-generation cephalosporins, carbapenems and fluoroquinolones). The results of this pilot study have allowed for the characterization of resistant profiles in Escherichia coli, Enterococcus faecalis and other bacterial species not previously reported in Apennine wolves. Our findings provide important insights into antibiotic resistance in wildlife and its potential implications for the conservation of biodiversity and public health. Full article
(This article belongs to the Special Issue Wildlife Sentinels of Antimicrobial Resistance)
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