New Insights on Biofilm Antimicrobial Strategies, 3rd Volume

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antibiofilm Strategies".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 1471

Special Issue Editors

1. CEB-Centre of Biological Engineering, University of Minho, 4710-057 Braga, Portugal
2. LABBELS–Associate Laboratory, 4710-057 Braga, Portugal
Interests: bacteriophages biofilms; prophagesstap hylococci; Helicobacter pylori
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Guest Editor
Laboratory for Process Engineering, Environment, Biotechnology and Energy, Faculty of Engineering, University of Porto, 4200-465 Porto, Portugal
Interests: multispecies biofilms; antibiotic agents; nucleic acid mimics; fluorescence in situ hybridization; human microbiota
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This is the 3rd edition of the Special Issue “New Insights on Biofilm Antimicrobial Strategies”. The use of antimicrobial agents is a common practice in a diverse array of settings (human and animal health, food industry, agriculture, farming, etc.). However, this practice has led to the emergence and spread of antibiotic-resistant bacteria, namely on biofilms. Biofilms are communities of microorganisms embedded within a self-produced matrix of extracellular polymeric substances. In addition to the biofilm matrix, biofilms are composed of cells with different physiologies and phenotypes. Both biofilm cells and matrix are involved in biofilm tolerance and resistance to antibiotics.

Hence, it is crucial to develop new and alternative strategies to detect, control, prevent or treat prejudicial biofilms. 

The issue welcomes various submission types, such as original research papers, short communications, reviews, and perspectives.

Potential topics for this Special Issue include but are not limited to different antifouling strategies:

  • Phages or phage-derived enzymes;
  • Use of physical approaches (photoporation; sonoporation);
  • Development of antimicrobial peptides or nucleic acid mimics;
  • Use of natural products;
  • Modification of surfaces to prevent biofilm formation;
  • Combinations of antimicrobial agents with a synergistic effect;
  • Development of technologies for the detection of single copy resistance genes (or eventually other virulence genes) in biofilms.

The articles published in this Special Issue should contribute to the successful treatment and control of resistant bacterial biofilms.

You are welcome to read the papers published in the two previous Special Issues:

New Insights on Biofilm Antimicrobial Strategies

New Insights on Biofilm Antimicrobial Strategies, 2nd Volume

Dr. Luís Melo
Dr. Andreia S. Azevedo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

13 pages, 445 KiB  
Article
From Hospital to Community: Exploring Antibiotic Resistance and Genes Associated with Virulence Factor Diversity of Coagulase-Positive Staphylococci
by Hazem Aqel, Naif Sannan and Ramy Foudah
Antibiotics 2023, 12(7), 1147; https://doi.org/10.3390/antibiotics12071147 - 04 Jul 2023
Cited by 2 | Viewed by 1145
Abstract
Coagulase-positive staphylococcus (CoPS), including methicillin-resistant Staphylococcus aureus (MRSA), poses a global threat. The increasing prevalence of MRSA in Saudi Arabia emphasizes the need for effective management. This study explores the prevalence of virulence-associated genes and antibiotic resistance patterns in CoPS. Nasal swabs from [...] Read more.
Coagulase-positive staphylococcus (CoPS), including methicillin-resistant Staphylococcus aureus (MRSA), poses a global threat. The increasing prevalence of MRSA in Saudi Arabia emphasizes the need for effective management. This study explores the prevalence of virulence-associated genes and antibiotic resistance patterns in CoPS. Nasal swabs from 200 individuals were collected, and standard protocols were used for the isolation, identification, and characterization of CoPS and coagulase-negative staphylococci (CoNS). Additionally, antimicrobial susceptibility testing and PCR were conducted. Bacterial growth was observed in 58.5% of participants, with 12% positive for CoPS and 30% positive for CoNS. Hospital personnel carriers showed a significantly higher proportion of CoNS compared with non-hospital personnel carriers. Non-hospital personnel CoPS strains displayed higher sensitivity to oxacillin than hospital personnel strains. Cefoxitin exhibited the highest sensitivity among β-lactam antibiotics. All isolates were sensitive to trimethoprim/sulfamethoxazole, rifampin, and quinupristin. Polymerase chain reaction analysis detected methicillin resistance genes in both non-hospital and hospital personnel MRSA strains. The coa and spa genes were prevalent in MRSA isolates, while the Luk-PV gene was not detected. A high prevalence of CoPS and CoNS was observed in both non-hospital and hospital personnel carriers. Occupational risk factors may contribute to the differences in the strain distribution. Varying antibiotic susceptibility patterns indicate the effectiveness of oxacillin and cefoxitin. Urgent management strategies are needed due to methicillin resistance. Further research is necessary to explore additional virulence-associated genes and develop comprehensive approaches for CoPS infection prevention and treatment in Saudi Arabia. Full article
(This article belongs to the Special Issue New Insights on Biofilm Antimicrobial Strategies, 3rd Volume)
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