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Antibiotics
Special Issues
Diagnosis, Management and Antibiotic Therapy of Urinary Tract Infections
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Diagnosis, Management and Antibiotic Therapy of Urinary Tract Infections

A special issue of Antibiotics (ISSN 2079-6382).

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 5023

Special Issue Editor

Dr. Giuseppe Magistro

E-Mail Website
Guest Editor
Department of Urology, Campus Großhadern, Ludwig-Maximilians-Universität München, Munich, Germany
Interests: urinary tract infection; antibiotics; vaccines; antimicrobial therapy

Special Issue Information

Dear Colleagues,

Infectious diseases have always been one of the most influential forces to influence social life, economy, and politics throughout human history. With the advent of hygiene and preventive measures, the first successful steps were made to check the rapid spread of infectious diseases. The discovery and introduction of antibiotics and vaccines were further milestones of the last century that equipped modern medicine with valuable instruments to manage infections. Antibiotics in particular emerged as the new “magic bullets” to successfully combat bacterial infections.  However, their overuse and misuse in recent decades have resulted in a new global healthcare crisis with the alarming increase in antimicrobial resistance (AMR). The first projections outlined a pre-antibiotic scenario with infectious disease as the number one cause of death on a global scale. Unfortunately, recent socio-economic analyses have confirmed this critical trend. Clinicians are obliged to change their current practice today if we aim to prevent this imminent threat to global health.

In this Special Issue, we aim to gather an interdisciplinary group of experts to report on the current developments and trends in the field to keep the reader up to date and to provide guidance for the management of urinary tract infections in our daily clinical practice.

Dr. Giuseppe Magistro
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • urinary tract infection
  • antibiotics
  • vaccines
  • antimicrobial resistance
  • infectious disease
  • diagnosis
  • antimicrobial therapy

Published Papers (3 papers)

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Research

9 pages, 787 KiB  
Article
Do or Don’t: Results of a Multinational Survey on Antibiotic Prophylaxis in Urodynamics
by Fabian P. Stangl, Laila Schneidewind, Florian M. Wagenlehner, Daniela Schultz-Lampel, Kaven Baeßler, Gert Naumann, Sandra Schönburg, Petra Anheuser, Susanne Winkelhog-Gran, Matthias Saar, Tanja Hüsch and Jennifer Kranz
Antibiotics 2023, 12(7), 1219; https://doi.org/10.3390/antibiotics12071219 - 22 Jul 2023
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Abstract
Antibiotic prophylaxis contributes substantially to the increase in antibiotic resistance rates worldwide. This investigation aims to assess the current standard of practice in using antibiotic prophylaxis for urodynamics (UDS) and identify barriers to guideline adherence. An online survey using a 22-item questionnaire designed [...] Read more.
Antibiotic prophylaxis contributes substantially to the increase in antibiotic resistance rates worldwide. This investigation aims to assess the current standard of practice in using antibiotic prophylaxis for urodynamics (UDS) and identify barriers to guideline adherence. An online survey using a 22-item questionnaire designed according to the Checklist for Reporting Results of Internet E-Surveys (CHERRIES) was circulated among urologists and gynecologists in Austria, Germany, and Switzerland between September 2021 and March 2022. A total of 105 questionnaires were eligible for analysis. Out of 105 completed surveys, most responders (n = 99, 94%) regularly perform dipstick urine analysis prior to urodynamics, but do not perform a urine culture (n = 68, 65%). Ninety-eight (93%) participants refrain from using antibiotic prophylaxis, and sixty-eight (65%) use prophylaxis if complicating factors exist. If asymptomatic bacteriuria is present, approximately 54 (52%) participants omit UDS and reschedule the procedure until antimicrobial susceptibility testing is available. Seventy-eight (78%) participants do not have a standard procedure for antibiotic prophylaxis in their department. Part of the strategy against the development of bacterial resistance is the optimized use of antibiotics, including antibiotic prophylaxis in urodynamics. Establishing a standard procedure is necessary and purposeful to harmonize both aspects in the field of urological diagnostics. Full article
(This article belongs to the Special Issue Diagnosis, Management and Antibiotic Therapy of Urinary Tract Infections)
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12 pages, 1407 KiB  
Article
Rapid Antibiotic Susceptibility Testing of Gram-Negative Bacteria Directly from Urine Samples of UTI Patients Using MALDI-TOF MS
by Felix R. Neuenschwander, Birgit Groß and Sören Schubert
Antibiotics 2023, 12(6), 1042; https://doi.org/10.3390/antibiotics12061042 - 12 Jun 2023
Cited by 1 | Viewed by 1950
Abstract
Urinary tract infections (UTIs) are one of the most common human infections and are most often caused by Gram-negative bacteria such as Escherichia coli. In view of the increasing number of antibiotic-resistant isolates, rapidly initiating effective antibiotic therapy is essential. Therefore, a [...] Read more.
Urinary tract infections (UTIs) are one of the most common human infections and are most often caused by Gram-negative bacteria such as Escherichia coli. In view of the increasing number of antibiotic-resistant isolates, rapidly initiating effective antibiotic therapy is essential. Therefore, a faster antibiotic susceptibility test (AST) is desirable. The MALDI-TOF MS-based phenotypic antibiotic susceptibility test (MALDI AST) has been used in blood culture diagnostics to rapidly detect antibiotic susceptibility. This study demonstrates for the first time that MALDI AST can be used to rapidly determine antibiotic susceptibility in UTIs directly from patients’ urine samples. MALDI-TOF MS enables the rapid identification and AST of Gram-negative UTIs within 4.5 h of receiving urine samples. Six urinary tract infection antibiotics, including ciprofloxacin, cotrimoxazole, fosfomycin, meropenem, cefuroxime, and nitrofurantoin, were analyzed and compared with conventional culture-based AST methods. A total of 105 urine samples from UTI patients contained bacterial isolates for MALDI AST. The combination of ID and AST by MALDI-TOF allowed us to interpret the result according to EUCAST guidelines. An overall agreement of 94.7% was found between MALDI AST and conventional AST for the urinary tract pathogens tested. Full article
(This article belongs to the Special Issue Diagnosis, Management and Antibiotic Therapy of Urinary Tract Infections)
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8 pages, 476 KiB  
Article
Practice Patterns in Fournier’s Gangrene in Europe and Implications for a Prospective Registry Study
by Laila Schneidewind, Bernhard Kiss, Fabian P. Stangl, Zafer Tandogdu, Florian M. E. Wagenlehner, Truls E. Bjerklund Johansen, Béla Köves, Jose Medina-Polo, Ana Maria Tapia and Jennifer Kranz
Antibiotics 2023, 12(2), 197; https://doi.org/10.3390/antibiotics12020197 - 18 Jan 2023
Cited by 1 | Viewed by 1754
Abstract
Background: Fournier’s gangrene (FG) is a life-threatening, necrotizing infection. Due to the rareness of the disease, it is challenging to plan robust prospective studies. This study aims to describe current practice patterns of FG in Europe and identify implications for planning a prospective [...] Read more.
Background: Fournier’s gangrene (FG) is a life-threatening, necrotizing infection. Due to the rareness of the disease, it is challenging to plan robust prospective studies. This study aims to describe current practice patterns of FG in Europe and identify implications for planning a prospective FG registry. Methods: Online non-validated 17-items survey among urologists treating FG in in European hospitals. Questionnaires were analyzed with LimeSurvey (LimeSurvey GmbH Hamburg, Germany). Results: 229 responses from ten different European countries were submitted, and 117 (51.1%) urologists completed the questionnaire. The departments treat a mean of 4.2 (SD 3.11) patients per year. The urology department mostly takes the lead in treating FG patients (n = 113; 96.6%). The practice in FG is very heterogenic and mostly case-based all over Europe, e.g., vacuum-assisted wound closure (VAC) is mostly used (n = 50; 42.7%) as adjunct wound. The biggest challenges in FG are the short time to diagnosis and treatment, standardization and establishment of guidelines, and disease awareness. Additionally, participants stated that an international registry is an outstanding initiative, and predictive models are needed. Conclusions: There is no standard of care in the diagnosis, treatment, and long-term care of FG all over Europe. Further research could be conducted with a prospective registry. Full article
(This article belongs to the Special Issue Diagnosis, Management and Antibiotic Therapy of Urinary Tract Infections)
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