Microbiome-Derived Metabolites in Animal Nutrition, Health and Disease

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Physiology".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 4554

Special Issue Editors


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Guest Editor
Food & Bio-Based Products, AgResearch Ltd, Palmerston North 4442, New Zealand
Interests: microbiome; fermentation metabolites; nutrition; host-microbiome interactions

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Guest Editor
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, Texas A&M University, College Station, TX 77843, USA
Interests: gut microbiome; fecal metabolomics; gastrointestinal diseases; canine; feline
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Special Issue Information

Dear Colleagues,

The gut microbiome is an exciting and quickly evolving field of study. However, as more knowledge becomes available, it is becoming clear that we must go beyond answering “who is there?”, towards a more pressing question of “what are they doing?”. Indeed, the microbiome is a complex, functional organ that provides nutrients vital to the health of its host, for example, the production of butyrate, a short-chain fatty acid essential for animal intestinal health. Butyrate is the main source of energy for colonocytes, and can be produced by many bacterial species through different metabolic pathways.

Microbiome-derived metabolites can also influence biological functions beyond the gastrointestinal tract. They help preserve gut homeostasis by strengthening the gut-blood barrier, modulate inflammatory responses, and even affect neurologic functions through the gut–brain axis. Therefore, investigating the impact of diet and diseases in the production of those metabolites can have a significant impact on how we understand health promotion and pathogenesis, and may open the doors to new therapeutic targets in animal treatment.

Original manuscripts that investigate the in vivo production of microbiome-derived metabolites are invited for this Special Issue. Topics of special interest include how animals’ diets, nutrition, or diseases affect the production of microbiome-derived metabolites, and articles that incorporate dataset integration to identify potential microbial sources for those metabolites are especially welcome.

Dr. Emma Bermingham
Dr. Rachel Pilla
Guest Editors

Manuscript Submission Information

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Keywords

  • microbiome
  • metabolites
  • SCFA
  • in vivo
  • animal models
  • diet
  • disease
  • dataset integration

Published Papers (1 paper)

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Research

19 pages, 1673 KiB  
Article
Long-Term Recovery of the Fecal Microbiome and Metabolome of Dogs with Steroid-Responsive Enteropathy
by Rachel Pilla, Blake C Guard, Amanda B Blake, Mark Ackermann, Craig Webb, Steve Hill, Jonathan A Lidbury, Jörg M Steiner, Albert E. Jergens and Jan S Suchodolski
Animals 2021, 11(9), 2498; https://doi.org/10.3390/ani11092498 - 25 Aug 2021
Cited by 13 | Viewed by 3432
Abstract
The long-term impact of treatment of dogs with steroid-responsive enteropathy (SRE) on the fecal microbiome and metabolome has not been investigated. Therefore, this study aimed to evaluate the fecal microbiome and metabolome of dogs with SRE before, during, and following treatment with standard [...] Read more.
The long-term impact of treatment of dogs with steroid-responsive enteropathy (SRE) on the fecal microbiome and metabolome has not been investigated. Therefore, this study aimed to evaluate the fecal microbiome and metabolome of dogs with SRE before, during, and following treatment with standard immunosuppressive therapy and an elimination diet. We retrospectively selected samples from 9 dogs with SRE enrolled in a previous clinical trial, which received treatment for 8 weeks, and had achieved remission as indicated by the post-treatment clinical scores. Long-term (1 year) samples were obtained from a subset (5/9) of dogs. Samples from 13 healthy dogs were included as controls (HC). We evaluated the microbiome using 16S rRNA sequencing and qPCR. To evaluate the recovery of gut function, we measured fecal metabolites using an untargeted approach. While improvement was observed for some bacterial taxa after 8 weeks of treatment, several bacterial taxa remained significantly different from HC. Seventy-five metabolites were altered in dogs with SRE, including increased fecal amino acids and vitamins, suggesting malabsorption as a component of SRE. One year after treatment, however, all bacterial species were evaluated by qPCR and 16S rRNA gene sequencing, and all but thirteen metabolites were no longer different from healthy controls. Full article
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