Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.2
3.0
Journals
Animals
Special Issues
The World of Adipokines: Their Presence and Distribution in the...
share announcement

The World of Adipokines: Their Presence and Distribution in the Organism and Their Relevance in Veterinary Medicine

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 14767

Special Issue Editors

Dr. Cecilia Dall'Aglio

E-Mail Website
Guest Editor
Department of Veterinary Medicine, University of Perugia, Via San Costanzo 4, 06126 Perugia, Italy
Interests: adipokines; orexins; cannabinoids; immunohistochemical techniques; domestic animals; exocrine glands; genital tract; diets; metabolism
Special Issues, Collections and Topics in MDPI journals
Prof. Francesca Mercati

E-Mail Website
Guest Editor
Department of Veterinary Medicine, University of Perugia, Perugia, Italy
Interests: hair follicle; skin; stem cells; reproductive apparatus; adipokines; immunohistochemical techniques; morphometry; energetic metabolism.
Dr. Paola Scocco

E-Mail Website
Guest Editor
School of Biosciences and Veterinary Medicine, University of Camerino (MC), 62032 Camerino, Italy
Interests: histochemistry; morphometry; animal welfare; food intake; digestive apparatus; reproductive apparatus; mammary gland; ruminants; environmental sustainability
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The word “adipokines” generally identifies all the molecules synthesized and secreted by the adipose tissue. This evidence suggests that the adipose tissue can be no longer seen only as a storage tissue but also as a real “endocrine organ”. The adipokines carry out a local action (autocrine/paracrine) on the same producing tissue but also a systemic one (endocrine) on different target organs and tissues. The numerous studies conducted in this regard and the evidence of their distribution, often ubiquitous, with the presence of production sites additional to the adipose tissue, have allowed us to hypothesize and, in some cases, to demonstrate their involvement in the functional control of the organs where they have been highlighted.

Original manuscripts, review articles, and short communications and commentaries, which address any aspects of adipokines in domestic and wild animals, are invited for this special issue. Manuscripts that use a multidisciplinary approach and address any aspect of adipokines with a direct impact on animal welfare are particularly welcome.

Dr. Cecilia Dall'Aglio
Prof. Francesca Mercati
Dr. Paola Scocco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adipocytokines
  • energetic metabolism
  • domestic animals
  • wild animals
  • animal welfare
  • obesity

Published Papers (6 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

9 pages, 2695 KiB  
Communication
Immunolocalization of Nesfatin-1 in the Gastrointestinal Tract of the Common Bottlenose Dolphin Tursiops truncatus
by Elena De Felice, Claudia Gatta, Daniela Giaquinto, Federica Fioretto, Lucianna Maruccio, Danila d’Angelo, Paola Scocco, Paolo de Girolamo and Livia D’Angelo
Animals 2022, 12(16), 2148; https://doi.org/10.3390/ani12162148 - 22 Aug 2022
Viewed by 1675
Abstract
First identified as an anorexigenic peptide, in the last decades, several studies have suggested that Nesfatin-1 (Nesf-1) is a pleiotropic hormone implicated in numerous regulatory processes in peripheral organs and tissues. In vertebrates, Nesf-1 is indeed expressed in the central nervous system and [...] Read more.
First identified as an anorexigenic peptide, in the last decades, several studies have suggested that Nesfatin-1 (Nesf-1) is a pleiotropic hormone implicated in numerous regulatory processes in peripheral organs and tissues. In vertebrates, Nesf-1 is indeed expressed in the central nervous system and peripheral organs. In this study, we characterized the pattern of Nesf-1 distribution within the digestive tract of the common bottlenose dolphin (Tursiops truncatus), composed of three gastric chambers and an intestine without a clear subdivision in the small and large intestine, also lacking a caecum. Our results indicated that Nesf-1 is widely distributed in cells of the mucosal epithelium of the gastric chambers. Most of the immunoreactivity was observed in the second chamber, compared to the first and third chambers. Immunopositivity was also found in nerve fibers and neurons, scattered or/and clustered in ganglion structures along all the examined gastrointestinal tracts. These observations add new data on the highly conserved role of Nesf-1 in the mammalian digestive system. Full article
(This article belongs to the Special Issue The World of Adipokines: Their Presence and Distribution in the Organism and Their Relevance in Veterinary Medicine)
►▼ Show Figures

Figure 1

13 pages, 1427 KiB  
Article
Effects of Leptin, Growth Hormone and Photoperiod on Pituitary SOCS-3 Expression in Sheep
by Dorota Anna Zieba, Malgorzata Szczesna, Katarzyna Kirsz and Weronika Biernat
Animals 2022, 12(3), 403; https://doi.org/10.3390/ani12030403 - 08 Feb 2022
Cited by 1 | Viewed by 1506
Abstract
This study examined how leptin affects growth hormone (GH) release and investigated the effects of leptin, GH, and day length on the suppressor of cytokine signaling-3 (SOCS-3) mRNA levels in the adenohypophyses of sheep. The study consisted of two experiments. The first experiment [...] Read more.
This study examined how leptin affects growth hormone (GH) release and investigated the effects of leptin, GH, and day length on the suppressor of cytokine signaling-3 (SOCS-3) mRNA levels in the adenohypophyses of sheep. The study consisted of two experiments. The first experiment was conducted during long (LD) and short (SD) days. Within-season and replicate sheep were centrally infused with Ringer-Locke buffer or leptin three times at 60-min intervals at the beginning of experiments. The second experiment involved adenohypophyses collected from sheep that were euthanized in May or November. Pituitary explants were treated with medium alone (Control) or medium with leptin or GH at different concentrations and incubated for various times. The results of the first experiment indicated GH concentrations were seasonally dependent and that leptin had no effect on GH secretion. The results of the second experiment indicated a stronger influence of leptin on the expression of SOCS-3 during the SD season than the LD season. During SDs, significant effects of both GH doses on SOCS-3 expression were observed. These results indicate a strong association between leptin, GH, and SOCS-3, which may explain the disruption of SOCS-3 leptin and GH signaling and the dominant effect of photoperiod on the above relationships. Full article
(This article belongs to the Special Issue The World of Adipokines: Their Presence and Distribution in the Organism and Their Relevance in Veterinary Medicine)
►▼ Show Figures

Figure 1

10 pages, 1724 KiB  
Article
The Apelinergic System Immuno-Detection in the Abomasum and Duodenum of Sheep Grazing on Semi-Natural Pasture
by Elisa Palmioli, Cecilia Dall’Aglio, Michele Bellesi, Federico Maria Tardella, Sara Moscatelli, Paola Scocco and Francesca Mercati
Animals 2021, 11(11), 3173; https://doi.org/10.3390/ani11113173 - 06 Nov 2021
Cited by 4 | Viewed by 1945
Abstract
Apelin (APLN) is an adipokine mainly produced by adipose tissue and related to an individual’s nutritional status as well as digestive apparatus functions. In this work, APLN and its receptor (APLNR) were investigated, by immunohistochemistry, in the abomasum and duodenum of 15 Comisana [...] Read more.
Apelin (APLN) is an adipokine mainly produced by adipose tissue and related to an individual’s nutritional status as well as digestive apparatus functions. In this work, APLN and its receptor (APLNR) were investigated, by immunohistochemistry, in the abomasum and duodenum of 15 Comisana × Appenninica adult sheep reared in a semi-natural pasture. Organ samples were collected after maximum pasture flowering (M × F group) and after maximum pasture dryness (M × D group); the experimental group (E × p group) received a feed supplementation of 600 grams/day/head of barley and corn in addition to M × D group feeding. APLN and APLNR were identified in the lining epithelium and the fundic gland chief cells of the abomasum. APLNR was observed in the lining epithelium, in the crypts and the serotonin secreting cells of the duodenum. Similar reactivity was observed between the M × F and E × p groups, while the M × D group showed a lower intensity of immunostaining for both APLN and APLNR in all positive structures but the duodenal serotonin neuroendocrine cells. Hence, our findings show that the E × p group presents a picture quite overlapped with M × F and suggest that food supplementation has a maintaining effect on the apelinergic system expression in the investigated digestive tracts of the sheep. Full article
(This article belongs to the Special Issue The World of Adipokines: Their Presence and Distribution in the Organism and Their Relevance in Veterinary Medicine)
►▼ Show Figures

Figure 1

14 pages, 1682 KiB  
Article
Seasonal and Nutritional Fluctuations in the mRNA Levels of the Short Form of the Leptin Receptor (LRa) in the Hypothalamus and Anterior Pituitary in Resistin-Treated Sheep
by Weronika Biernat, Malgorzata Szczęsna, Katarzyna Kirsz and Dorota Anna Zieba
Animals 2021, 11(8), 2451; https://doi.org/10.3390/ani11082451 - 20 Aug 2021
Cited by 2 | Viewed by 2431
Abstract
The short form of the leptin receptor (LRa) plays a key role in the transport of leptin to the central nervous system (CNS). Here, the resistin (RSTN)-mediated expression of LRa in the preoptic area (POA), ventromedial and dorsomedial nuclei (VMH/DMH),arcuate nucleus [...] Read more.
The short form of the leptin receptor (LRa) plays a key role in the transport of leptin to the central nervous system (CNS). Here, the resistin (RSTN)-mediated expression of LRa in the preoptic area (POA), ventromedial and dorsomedial nuclei (VMH/DMH),arcuate nucleus (ARC) and the anterior pituitary gland (AP)was analyzed considering the photoperiodic (experiment 1) and nutritional status (experiment 2) of ewes. In experiment 1, 30 sheep were fed normally and received one injection of saline or two doses of RSTN one hour prior to euthanasia. RSTN increased LRa expression mainly in the ARC and AP during long days (LD) and only in the AP during short days (SD). In experiment 2, an altered diet for 5 months created lean or fat sheep. Twenty sheep were divided into four groups: the lean and fat groups were given saline, while the lean-R and fat-R groups received RSTN one hour prior to euthanasia. Changes in adiposity influenced the effect of RSTN on LRa mRNA transcript levels in the POA, ARC and AP and without detection of LRa in the VMH/DMH. Overall, both photoperiodic and nutritional signals influence the effects of RSTN on leptin transport to the CNS and are involved in the adaptive/pathological phenomenon of leptin resistance in sheep. Full article
(This article belongs to the Special Issue The World of Adipokines: Their Presence and Distribution in the Organism and Their Relevance in Veterinary Medicine)
►▼ Show Figures

Figure 1

13 pages, 1639 KiB  
Article
Effects of Obesity on Adiponectin System Skin Expression in Dogs: A Comparative Study
by Cecilia Dall’Aglio, Margherita Maranesi, Antonio Di Loria, Diego Piantedosi, Paolo Ciaramella, Maria Chiara Alterisio, Elvio Lepri and Francesca Mercati
Animals 2021, 11(8), 2308; https://doi.org/10.3390/ani11082308 - 05 Aug 2021
Cited by 10 | Viewed by 3188
Abstract
Obesity is an important health issue in dogs since it influences a plethora of associated pathologies, including dermatological disorders. Considering the scarcity of information in pets, this work aimed to evaluate the localization and expression of adiponectin (ADIPOQ) and its two receptors (ADIPOR1 [...] Read more.
Obesity is an important health issue in dogs since it influences a plethora of associated pathologies, including dermatological disorders. Considering the scarcity of information in pets, this work aimed to evaluate the localization and expression of adiponectin (ADIPOQ) and its two receptors (ADIPOR1 and ADIPOR2) in the skin of 10 obese dogs, compared with serum ADIPOQ level. Through immunohistochemistry, ADIPOQ and ADIPOR2 were observed in the adipose tissue, sweat and sebaceous glands, endothelium, and some connective cells. Both receptors were observed in the epidermis and the hair follicles, other than in the sweat and sebaceous glands. Real-time PCR evidenced that the ADIPOQ and ADIPOR2 transcripts were expressed 5.4-fold (p < 0.01) and 2.3-fold less (p < 0.01), respectively, in obese than in normal weight dogs, while ADIPOR1 expression did not change. Obese dogs showed lower serum ADIPOQ levels than the normal weight group. Accordingly, ADIPOQ and ADIPOR2 expression in the skin appear negatively correlated with obesity in the same way as the serum ADIPOQ level. These findings evidence that ADIPOQ system changes in the skin of obese dogs and suggest that the ADIPOQ effect on the skin is at least in part regulated by the reduced expression of ADIPOR2. Full article
(This article belongs to the Special Issue The World of Adipokines: Their Presence and Distribution in the Organism and Their Relevance in Veterinary Medicine)
►▼ Show Figures

Figure 1

14 pages, 1409 KiB  
Article
Leptin System in Obese Dog Skin: A Pilot Study
by Margherita Maranesi, Antonio Di Loria, Cecilia Dall’Aglio, Diego Piantedosi, Elvio Lepri, Paolo Ciaramella and Francesca Mercati
Animals 2020, 10(12), 2338; https://doi.org/10.3390/ani10122338 - 09 Dec 2020
Cited by 7 | Viewed by 2322
Abstract
Obesity predisposes to several health problems including skin diseases. However, information on the relationship between obesity and skin disorders in pets is very scarce. Leptin (LEP) is mainly produced by adipose tissue and has a prominent role in skin biology. This study evaluated [...] Read more.
Obesity predisposes to several health problems including skin diseases. However, information on the relationship between obesity and skin disorders in pets is very scarce. Leptin (LEP) is mainly produced by adipose tissue and has a prominent role in skin biology. This study evaluated the LEP system in the skin of obese dogs compared to normal-weight animals. The investigation was carried out on 10 obese (Obese group) and 10 normal-weight (Normal-weight group) dogs through Real-time PCR and immunohistochemistry. Cells of skin associated immune system were also evaluated. No differences were evidenced between the two groups as well as skin inflammation. LEP differences were no significant, while LEPR transcript appeared 10-fold higher in obesedogs than in normal-weight ones. Immunostaining for both molecules was observed in several skin structures such as the epidermis, hair follicles, and glands. No differences appeared in the skin associated immune system composition. This study is a preliminary report showing that LEP system changes in obese dog skin. The increased LEPR expression observed in the obese group suggests that the receptor plays a modulating role in the system control. However, the exact role of LEPin the skin under obesity conditions needs further elucidation. Full article
(This article belongs to the Special Issue The World of Adipokines: Their Presence and Distribution in the Organism and Their Relevance in Veterinary Medicine)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-6
Back to TopTop