Chromatin and Transcriptome Signatures of Skeletal Muscle in Different Pathophysiological Settings

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Animal Genetics and Genomics".

Deadline for manuscript submissions: closed (30 April 2021) | Viewed by 2898

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Guest Editor
Department of Diagnostic and Health Sciences, College of Health Professions, The University of Tennessee Health Science Center, Memphis, TN, USA
Interests: aging; stroke; skeletal muscle atrophy, growth, regeneration, and metabolism; genomics; proteomics; metabolomics; bioinformatics
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Special Issue Information

Skeletal muscle, which accounts for 40% of total body weight, has diverse functions, including maintaining body posture and producing mobility and movement. Skeletal muscle is also essential for maintaining whole-body energy homeostasis in terms of glucose and fatty acid metabolism. Muscle tissue deteriorates with aging, both quantitatively and qualitatively, which increases the chances of falls as well as developing osteoporosis and metabolic diseases. Thus, maintaining muscle mass is important for a healthier life. Chromatin and transcriptome sequencing and microarrays—analytical techniques which can now be feasibly completed within a few days—have greatly advanced our understanding of the pathophysiology of many diseases. Essentially, such research has enabled important advances in clinical research and continues to guide treatment. This Special Issue covers topics related to DNA and RNA sequencing or microarray data of muscle tissue from any animal (invertebrates and vertebrates). Authors interested in contributing their research findings to this Special Issue are invited to provide a tentative title and author details to the Guest Editor, with the submission of full articles before 30 April 2021. Manuscripts will be subject to peer review according to the standard procedures of Animal journal. Upon manuscript submission, please indicate that your manuscript has prepared for the Special Issue “Chromatin and Transcriptome Signatures of Skeletal Muscle in Different Pathophysiological Settings”.

Dr. Junaith S. Mohamed
Guest Editor

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Keywords

  • skeletal muscle
  • RNA- and DNA-sequencing
  • ChIP-sequencing
  • microarray
  • muscle wasting
  • muscle weakness
  • chromatin modifications
  • transcriptomes
  • microRNAs
  • long noncoding RNAs

Published Papers (1 paper)

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Research

13 pages, 3064 KiB  
Article
PDLIM5 Affects Chicken Skeletal Muscle Satellite Cell Proliferation and Differentiation via the p38-MAPK Pathway
by Haorong He, Huadong Yin, Xueke Yu, Yao Zhang, Menggen Ma, Diyan Li and Qing Zhu
Animals 2021, 11(4), 1016; https://doi.org/10.3390/ani11041016 - 4 Apr 2021
Cited by 10 | Viewed by 2594
Abstract
Skeletal muscle satellite cell growth and development is a complicated process driven by multiple genes. The PDZ and LIM domain 5 (PDLIM5) gene has been proven to function in C2C12 myoblast differentiation and is involved in the regulation of skeletal muscle development. The [...] Read more.
Skeletal muscle satellite cell growth and development is a complicated process driven by multiple genes. The PDZ and LIM domain 5 (PDLIM5) gene has been proven to function in C2C12 myoblast differentiation and is involved in the regulation of skeletal muscle development. The role of PDLIM5 in chicken skeletal muscle satellite cells, however, is unclear. In this study, in order to determine whether the PDLIM5 gene has a function in chicken skeletal muscle satellite cells, we examined the changes in proliferation and differentiation of chicken skeletal muscle satellite cells (SMSCs) after interfering and overexpressing PDLIM5 in cells. In addition, the molecular pathways of the PDLIM5 gene regulating SMSC proliferation and differentiation were analyzed by transcriptome sequencing. Our results show that PDLIM5 can promote the proliferation and differentiation of SMSCs; furthermore, through transcriptome sequencing, it can be found that the differential genes are enriched in the MAPK signaling pathway after knocking down PDLIM5. Finally, it was verified that PDLIM5 played an active role in the proliferation and differentiation of chicken SMSCs by activating the p38-MAPK signaling pathway. These results indicate that PDLIM5 may be involved in the growth and development of chicken skeletal muscle. Full article
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