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Animals
Special Issues
Pharmacokinetics and Pharmacodynamics in Veterinary Medicine
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Pharmacokinetics and Pharmacodynamics in Veterinary Medicine

A special issue of Animals (ISSN 2076-2615).

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 3088

Special Issue Editor

Dr. Pedro Marín Carrillo

E-Mail Website
Guest Editor
Department of Pharmacology, Faculty of Veterinary Medicine, University of Murcia, 30071 Murcia, Spain
Interests: pharmacokinetics; antibiotics; anesthetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

The selection of the most appropriate drug or combination of drugs as well as the identification of the treatment regimen that maximizes drug efficacy and minimizes drug toxicity are the main objective of pharmacotherapy. In veterinary medicine, pharmacokinetic data are often unavailable for new drugs or for drugs in a particular species, such as minor or exotic species. For these animals, there are few registered drugs that could be used under exceptional prescription by adapting or extrapolating the recommended dosage from major species. This extrapolation can cause potential overdosing or under-dosing and the presence of residues of these pharmacologically active substances in meat or other animal-derived products intended for human consumption.

The aim of this Special Issue is to present original research papers or reviews about the pharmacokinetics (PK), pharmacodynamics (PD), and PK/PD integration of drugs to ensure clinical success, minimize drug toxicity, and prevent the presence of drug residues in food.

Areas of interest relevant to this Special Issue include the following: pharmacokinetics, pharmacokinetic drug interactions, pharmacodynamics, PK/PD integration, bioavailability, drug dosage adjustment, efficacy studies, and withdrawal periods.

We invite you to share your recent findings through this Special Issue.

Dr. Pedro Marín Carrillo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Animals is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmacokinetics
  • drug interactions
  • pharmacodynamics
  • PK/PD integration
  • bioavailability
  • efficacy studies
  • withdrawal periods

Published Papers (1 paper)

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Research

11 pages, 772 KiB  
Article
Pharmacokinetics and Pharmacokinetic/Pharmacodynamic Integration of Enrofloxacin Following Single Oral Administration of Different Doses in Brown Trout (Salmo trutta)
by Kamil Uney, Ertugrul Terzi, Duygu Durna Corum, Rahmi Can Ozdemir, Soner Bilen and Orhan Corum
Animals 2021, 11(11), 3086; https://doi.org/10.3390/ani11113086 - 28 Oct 2021
Cited by 16 | Viewed by 2082
Abstract
The pharmacokinetic of enrofloxacin was investigated in brown trout (Salmo trutta) following oral administration of 10, 20, and 40 mg/kg doses at 11 ± 1.5 °C. Furthermore, MICs of enrofloxacin against Aeromonas hydrophila and A. sobria were determined. The plasma concentrations [...] Read more.
The pharmacokinetic of enrofloxacin was investigated in brown trout (Salmo trutta) following oral administration of 10, 20, and 40 mg/kg doses at 11 ± 1.5 °C. Furthermore, MICs of enrofloxacin against Aeromonas hydrophila and A. sobria were determined. The plasma concentrations of enrofloxacin and ciprofloxacin were determined using HPLC–UV and analyzed by non-compartmental method. Following oral administration at dose of 10 mg/kg, total clearance (CL/F), area under the concentration–time curve (AUC0−∞) and peak plasma concentrations (Cmax) were 41.32 mL/h/kg, 242.02 h*μg/mL and 4.63 μg/mL, respectively. When compared to 10 mg/kg dose, the dose-normalized AUC0–∞ and Cmax were increased by 56.30% and 30.08%, respectively, while CL/F decreased by 38.4% at 40 mg/kg dose, suggesting the non-linearity. Ciprofloxacin was not detected in the all of plasma samples. The MIC values of enrofloxacin were ranged 0.0625–4 μg/mL for A. hydrophila and 0.0625–2 μg/mL for A. sobria. The oral administration of enrofloxacin at 10 (for 192 h) and 20 (for 240 h) mg/kg doses provided the AUC of enrofloxacin equal to 1.23 and 1.96-fold MICs, respectively, for A. hydrophila and A. sobria with the MIC90 values of 1 µg/mL. However, further researches are needed on the PK/PD study of enrofloxacin for the successful treatment of infections caused by A. hydrophila and A. sobria in brown trout. Full article
(This article belongs to the Special Issue Pharmacokinetics and Pharmacodynamics in Veterinary Medicine)
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