Alternative Methods in Biological Assays
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 9674
Interests: animals of pharmacology and toxicology; invertebrate animals; computational models
Special Issues, Collections and Topics in MDPI journals
Experimental animal data are the cornerstone in pharmacology, toxicology, and risk assessment; however, promoting good animal welfare is a contentious issue in drug research. The need to reduce the pain and distress experienced by animals during scientific experiments highlights the importance of the principles of replacing, reducing, and refining animal use in the study of biomolecules. There is an urgent need to develop and use replacement and reduction alternative techniques that could substitute for a significant proportion of animal research at every level of preclinical studies.
Several alternative models, such as copepod (Tigriopus spp.), water flea (Daphnia spp.), brine shrimp (Artemia salina), Caenorhabditis elegans, fathead minnow (Pimephales promelas), zebrafish (Danio rerio), and rainbow trout (Oncorhynchus mykiss), have been developed and proven to be successful, especially with respect to the testing of chemical toxicity. Some of these models could be extended in many other biomedical research fields, including basic developmental biology or pharmacology, in order to capitalize on their potential to model human diseases. Lower vertebrates are an attractive option because of the reduced ethical impact and their good genetic relatedness to mammals.
This Special Issue will focus on research studies highlighting the development of alternative assays and testing strategies to model human responses. This Special Issue aims to bring together multi- and interdisciplinary approaches driven by the concept of the 3Rs (reduction, refinement, and replacement) in drug development. Of special interest is research on the use of alternative species or methods for complex pharmacology studies, such as those related to memory, aging, endocrine dysfunction, muscle dystrophy, and diabetes, to name a few.
Prof. Dr. Nitulescu George Mihai
Manuscript Submission Information
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- alternative pharmacology tests
- Daphnia spp.
- Artemia salina
- Danio rerio
- Caenorhabditis elegans