The Innate Immune Responses of Fish to Infectious Diseases

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Aquatic Animals".

Deadline for manuscript submissions: 15 June 2024 | Viewed by 1343

Special Issue Editors


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Guest Editor
College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, USA
Interests: host defense; trained immunity; phagocytosis; cytotoxicity; innate lymphoid cells; TLRs

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Guest Editor
Independent Researcher, Samsun, Turkey
Interests: fish immunology; fish innate immunity

Special Issue Information

Dear Colleagues, 

Innate immunity is the first line of defense to prevent non-self agents from entering and harming an individual. Evolution of the first single-celled organisms required the ability to distinguish self from non-self. This discrimination is the basis of immunity. Innate immunity is present in invertebrates, and began its diversification 530 million years ago, in the first fish. Unique modifications of innate immunity can be present in different types of fish. This Special Issue will bring readers up to date with the varied innate immune responses of fish to infectious diseases, and will include research and review articles about humoral and cell-mediated innate immune responses from different types of fish. The elucidation of common, unique and novel innate immune mechanisms among fishes allows us to better understand the ways the innate immune system can help defend against infectious agents in all vertebrates.

Dr. Lora Petrie-Hanson
Dr. Adef Kordon
Guest Editors

Manuscript Submission Information

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Keywords

  • fish immunology
  • fish innate immunity
  • host defense
  • trained immunity
  • phagocytosis
  • cytotoxicity
  • innate lymphoid cells
  • TLR

Published Papers (1 paper)

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Research

21 pages, 9802 KiB  
Article
Antibacterial Activity of Rainbow Trout Plasma: In Vitro Assays and Proteomic Analysis
by Toita Mizaeva, Kalimat Alieva, Eldar Zulkarneev, Stanislav Kurpe, Kseniya Isakova, Svetlana Matrosova, Ekaterina Borvinskaya and Irina Sukhovskaya
Animals 2023, 13(22), 3565; https://doi.org/10.3390/ani13223565 - 18 Nov 2023
Viewed by 1009
Abstract
The objective of this study was to investigate the bactericidal activity of blood plasma from cultured rainbow trout obtained from two different fish farms. Plasma from trout naturally infected with the bacterial pathogen Flavobacterium psychrophilum was found to inhibit the growth of Aeromonas [...] Read more.
The objective of this study was to investigate the bactericidal activity of blood plasma from cultured rainbow trout obtained from two different fish farms. Plasma from trout naturally infected with the bacterial pathogen Flavobacterium psychrophilum was found to inhibit the growth of Aeromonas hydrophila in vitro. Incubation of A. hydrophila in bacteriostatic trout plasma resulted in agglutination and growth retardation, without causing massive damage to the cell membrane. The proteome of the plasma with high antimicrobial activity revealed an abundance of high-density apolipoproteins, some isoforms of immunoglobulins, complement components C1q and C4, coagulation factors, lectins, periostin, and hemoglobin. Analysis of trout proteins retained on A. hydrophila cells revealed the presence of fish immunoglobulins, lectins, and complement components on bacteria whose growth was inhibited, although the native membrane attack complex of immunised trout plasma did not assemble effectively, resulting in a weak bactericidal effect. Furthermore, this study examined the bacterial response to trout plasma and suggested that the protein synthesis pathway was the target of antimicrobial proteins from fish blood. Taken together, these findings illustrate the advantages of the affinity approach for understanding the role of plasma proteins in host defence against pathogens. Full article
(This article belongs to the Special Issue The Innate Immune Responses of Fish to Infectious Diseases)
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