Assessment of Cardiovascular Function in Childhood Leukemia Survivors: The Role of the Right Heart
, Pietro Scicchitano 2, Vito Michele Rosario Muggeo 3, Chiara Novielli 1, Paola Giordano 4, Marco Matteo Ciccone 2, Maria Felicia Faienza 5,*,†and Nicola Santoro 1,†Round 1
Reviewer 1 Report
Dear authors,
In general it is a well written manuscript about an important topic of research in Cardiology. Congratulations for your novel and interesting work. My comments for you are the following:
1. You could include in the section of discussion the guidelines about diagnosis/management of patients who have received chemotherapy and have developed cardiac damage.
2. You should improve the legends of tables (please, explain in detail every abbreviation).
3. Please, correct some minor typographic errors (i.e. line 228).
4. Please, improve the reference style according to the journals needs.
Author Response
Review Report 1
Dear authors,
In general, it is a well written manuscript about an important topic of research in Cardiology. Congratulations for your novel and interesting work. My comments for you are the following:
- You could include in the section of discussion the guidelines about diagnosis/management of patients who have received chemotherapy and have developed cardiac damage.
Dear reviewer, we really appreciate your comments and we would like to thank you. A sentence about recent ESC guidelines on cardio-oncology has been added in the discussion with the corresponding reference.
- You should improve the legends of tables (please, explain in detail every abbreviation).
The table legends have been detailed.
- Please, correct some minor typographic errors (i.e. line 228).
Minor errors have been corrected.
- Please, improve the reference style according to the journal needs.
The reference style has been entirely revised and corrected.
Reviewer 2
Dear reviewer, thank you very much for your comments, corrections have been made as follows:
line 25, uncertain TEI index definition
A definition of Tei index has been added, moreover a reference from Tei C. has been added in the methods
line 212, exacerbated
Correction made
I appreciate the novel finding of worse RV systolic function compared to LV function and the presence of endothelial dysfunction as a measure of poorer overall impaired vascular health
table II no definition of TEI index in labels
An explanation of Tei index has been added in the table legend
Author Response File: 
Author Response.docx
Reviewer 2 Report
line 25, uncertain TEI index definition
line 212, exacerbated
I appreciate the novel finding of worse RV systolic function compared to LV function and the presence of endothelial dysfunction as a measure of poorer overall impaired vascular health
table II no definition of TEI index in labels
Author Response
Reviewer 2
Dear reviewer, thank you very much for your comments, corrections have been made as follows:
line 25, uncertain TEI index definition
A definition of Tei index has been added, moreover a reference from Tei C. has been added in the methods.
line 212, exacerbated
Correction made.
I appreciate the novel finding of worse RV systolic function compared to LV function and the presence of endothelial dysfunction as a measure of poorer overall impaired vascular health
table II no definition of TEI index in labels
An explanation of Tei index has been added in the table legend.
Author Response File: Author Response.docx
